Effect of statin treatment on circulating malondialdehyde concentrations: a systematic review and meta-analysis

Angelo Zinellu, Panagiotis Paliogiannis, Maria Franca Usai, Ciriaco Carru, Arduino A Mangoni

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Abstract

Background: The effect of statins on oxidative stress markers, such as malondialdehyde (MDA), is still a matter of debate. We sought to address this issue by conducting a systematic review and meta-analysis of published data on the effect of statin treatment on systemic MDA concentrations. Methods: A literature search was conducted on MEDLINE/PubMed, ISI Web of Sciences and Scopus. Data were pooled using a random-effects model. Results: A total of 35 studies assessing MDA concentrations before and after statin treatment in 1512 participants (mean age 53.6 years, 48.7% males) were identified. Extreme between-study heterogeneity was observed (I 2 = 96.0%, p < 0.001). Pooled standardized mean difference (SMD) showed a significant reduction in plasma MDA concentrations after treatment (SMD = −1.47 µmol/l, 95% confidence interval = −1.89 to −1.05 μmol/l; p < 0.001). Similarly, a subgroup analysis of 10 studies that also included a placebo group showed a significant reduction in plasma MDA concentrations with statins (−1.03 μmol/l, 95% confidence interval = −1.52 to −0.29 μmol/l; p = 0.036). Conclusions: This systematic review and meta-analysis showed that statin treatment significantly reduces systemic MDA concentrations. However, the results should be interpreted with caution because of extreme between-study heterogeneity, which warrants further intervention studies.

Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalTherapeutic Advances in Chronic Disease
Volume10
Issue number10
DOIs
Publication statusPublished - 1 Jan 2019

Bibliographical note

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

Keywords

  • malondialdehyde
  • meta-analysis
  • oxidative stress
  • random-effects model
  • statin
  • systematic review
  • thiobarbituric acid reactive substances
  • Oxidative stress
  • Random-effects model
  • Systematic review
  • Thiobarbituric acid reactive substances
  • Statin
  • Malondialdehyde
  • Meta-analysis

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