Effect of statin treatment on circulating malondialdehyde concentrations: a systematic review and meta-analysis

Angelo Zinellu; Panagiotis Paliogiannis; Maria Franca Usai; Ciriaco Carru; Arduino A Mangoni

doi:10.1177/2040622319862714

Effect of statin treatment on circulating malondialdehyde concentrations: a systematic review and meta-analysis

Angelo Zinellu, Panagiotis Paliogiannis, Maria Franca Usai, Ciriaco Carru, Arduino A Mangoni

College of Medicine and Public Health

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

4 Downloads (Pure)

Abstract

Background: The effect of statins on oxidative stress markers, such as malondialdehyde (MDA), is still a matter of debate. We sought to address this issue by conducting a systematic review and meta-analysis of published data on the effect of statin treatment on systemic MDA concentrations. Methods: A literature search was conducted on MEDLINE/PubMed, ISI Web of Sciences and Scopus. Data were pooled using a random-effects model. Results: A total of 35 studies assessing MDA concentrations before and after statin treatment in 1512 participants (mean age 53.6 years, 48.7% males) were identified. Extreme between-study heterogeneity was observed (I ² = 96.0%, p < 0.001). Pooled standardized mean difference (SMD) showed a significant reduction in plasma MDA concentrations after treatment (SMD = −1.47 µmol/l, 95% confidence interval = −1.89 to −1.05 μmol/l; p < 0.001). Similarly, a subgroup analysis of 10 studies that also included a placebo group showed a significant reduction in plasma MDA concentrations with statins (−1.03 μmol/l, 95% confidence interval = −1.52 to −0.29 μmol/l; p = 0.036). Conclusions: This systematic review and meta-analysis showed that statin treatment significantly reduces systemic MDA concentrations. However, the results should be interpreted with caution because of extreme between-study heterogeneity, which warrants further intervention studies.

Original language	English
Pages (from-to)	1-15
Number of pages	15
Journal	Therapeutic Advances in Chronic Disease
Volume	10
Issue number	10
DOIs	https://doi.org/10.1177/2040622319862714
Publication status	Published - 1 Jan 2019

Bibliographical note

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

Keywords

malondialdehyde
meta-analysis
oxidative stress
random-effects model
statin
systematic review
thiobarbituric acid reactive substances
Oxidative stress
Random-effects model
Systematic review
Thiobarbituric acid reactive substances
Statin
Malondialdehyde
Meta-analysis

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Zinellu_Creating_P2019Final published version, 2.34 MBLicence: CC BY-NC

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title = "Effect of statin treatment on circulating malondialdehyde concentrations: a systematic review and meta-analysis",

abstract = "Background: The effect of statins on oxidative stress markers, such as malondialdehyde (MDA), is still a matter of debate. We sought to address this issue by conducting a systematic review and meta-analysis of published data on the effect of statin treatment on systemic MDA concentrations. Methods: A literature search was conducted on MEDLINE/PubMed, ISI Web of Sciences and Scopus. Data were pooled using a random-effects model. Results: A total of 35 studies assessing MDA concentrations before and after statin treatment in 1512 participants (mean age 53.6 years, 48.7% males) were identified. Extreme between-study heterogeneity was observed (I 2 = 96.0%, p < 0.001). Pooled standardized mean difference (SMD) showed a significant reduction in plasma MDA concentrations after treatment (SMD = −1.47 µmol/l, 95% confidence interval = −1.89 to −1.05 μmol/l; p < 0.001). Similarly, a subgroup analysis of 10 studies that also included a placebo group showed a significant reduction in plasma MDA concentrations with statins (−1.03 μmol/l, 95% confidence interval = −1.52 to −0.29 μmol/l; p = 0.036). Conclusions: This systematic review and meta-analysis showed that statin treatment significantly reduces systemic MDA concentrations. However, the results should be interpreted with caution because of extreme between-study heterogeneity, which warrants further intervention studies. ",

keywords = "malondialdehyde, meta-analysis, oxidative stress, random-effects model, statin, systematic review, thiobarbituric acid reactive substances, Oxidative stress, Random-effects model, Systematic review, Thiobarbituric acid reactive substances, Statin, Malondialdehyde, Meta-analysis",

author = "Angelo Zinellu and Panagiotis Paliogiannis and Usai, {Maria Franca} and Ciriaco Carru and Mangoni, {Arduino A}",

note = "This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). ",

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Effect of statin treatment on circulating malondialdehyde concentrations : a systematic review and meta-analysis. / Zinellu, Angelo; Paliogiannis, Panagiotis; Usai, Maria Franca; Carru, Ciriaco; Mangoni, Arduino A.

In: Therapeutic Advances in Chronic Disease, Vol. 10, No. 10, 01.01.2019, p. 1-15.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Effect of statin treatment on circulating malondialdehyde concentrations

T2 - a systematic review and meta-analysis

AU - Zinellu, Angelo

AU - Paliogiannis, Panagiotis

AU - Usai, Maria Franca

AU - Carru, Ciriaco

AU - Mangoni, Arduino A

N1 - This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: The effect of statins on oxidative stress markers, such as malondialdehyde (MDA), is still a matter of debate. We sought to address this issue by conducting a systematic review and meta-analysis of published data on the effect of statin treatment on systemic MDA concentrations. Methods: A literature search was conducted on MEDLINE/PubMed, ISI Web of Sciences and Scopus. Data were pooled using a random-effects model. Results: A total of 35 studies assessing MDA concentrations before and after statin treatment in 1512 participants (mean age 53.6 years, 48.7% males) were identified. Extreme between-study heterogeneity was observed (I 2 = 96.0%, p < 0.001). Pooled standardized mean difference (SMD) showed a significant reduction in plasma MDA concentrations after treatment (SMD = −1.47 µmol/l, 95% confidence interval = −1.89 to −1.05 μmol/l; p < 0.001). Similarly, a subgroup analysis of 10 studies that also included a placebo group showed a significant reduction in plasma MDA concentrations with statins (−1.03 μmol/l, 95% confidence interval = −1.52 to −0.29 μmol/l; p = 0.036). Conclusions: This systematic review and meta-analysis showed that statin treatment significantly reduces systemic MDA concentrations. However, the results should be interpreted with caution because of extreme between-study heterogeneity, which warrants further intervention studies.

AB - Background: The effect of statins on oxidative stress markers, such as malondialdehyde (MDA), is still a matter of debate. We sought to address this issue by conducting a systematic review and meta-analysis of published data on the effect of statin treatment on systemic MDA concentrations. Methods: A literature search was conducted on MEDLINE/PubMed, ISI Web of Sciences and Scopus. Data were pooled using a random-effects model. Results: A total of 35 studies assessing MDA concentrations before and after statin treatment in 1512 participants (mean age 53.6 years, 48.7% males) were identified. Extreme between-study heterogeneity was observed (I 2 = 96.0%, p < 0.001). Pooled standardized mean difference (SMD) showed a significant reduction in plasma MDA concentrations after treatment (SMD = −1.47 µmol/l, 95% confidence interval = −1.89 to −1.05 μmol/l; p < 0.001). Similarly, a subgroup analysis of 10 studies that also included a placebo group showed a significant reduction in plasma MDA concentrations with statins (−1.03 μmol/l, 95% confidence interval = −1.52 to −0.29 μmol/l; p = 0.036). Conclusions: This systematic review and meta-analysis showed that statin treatment significantly reduces systemic MDA concentrations. However, the results should be interpreted with caution because of extreme between-study heterogeneity, which warrants further intervention studies.

KW - malondialdehyde

KW - meta-analysis

KW - oxidative stress

KW - random-effects model

KW - statin

KW - systematic review

KW - thiobarbituric acid reactive substances

KW - Oxidative stress

KW - Random-effects model

KW - Systematic review

KW - Thiobarbituric acid reactive substances

KW - Statin

KW - Malondialdehyde

KW - Meta-analysis

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DO - 10.1177/2040622319862714

M3 - Review article

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JO - Therapeutic Advances in Chronic Disease

JF - Therapeutic Advances in Chronic Disease

SN - 2040-6223

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ER -

Effect of statin treatment on circulating malondialdehyde concentrations: a systematic review and meta-analysis

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