TY - JOUR
T1 - Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: A test-negative case control study
AU - Cheng, Allen
AU - Kotsimbos, Tom
AU - Kelly, Heath
AU - Irving, Louis
AU - Bowler, Simon
AU - Brown, Simon
AU - Holmes, Mark
AU - Jenkins, Christine Jenkins,
AU - Thompson, Philip
AU - Simpson, Grahame
AU - Wood-Baker, Richard
AU - Senanayake, Sanjaya
AU - Brady, Stephen
AU - Paterson, David
AU - Wark, Peter
AU - Upham, John
AU - Korman, Tony
AU - Dwyer, Dominic
AU - Waterer, Grant
AU - Kelly, P
PY - 2011/10/6
Y1 - 2011/10/6
N2 - We aimed to estimate the effectiveness of H1N1/09 containing influenza vaccines against hospitalization from influenza in Australia. We performed a test-negative case control study in patients hospitalized in 15 sentinel Australian hospitals between March and November 2010, comparing influenza vaccination (H1N1/09 monovalent or 2010 seasonal trivalent) in hospitalized patients with PCR-confirmed influenza compared to PCR-negative controls. Between March and November 2010, 1169 hospitalized patients were tested for suspected influenza, of which influenza vaccine status was ascertained in 165/238 patients with H1N1/09 influenza, 40/64 with seasonal influenza and 558/867 test negative controls; 24% of H1N1/09 cases, 43% of seasonal influenza cases and 54% of controls were vaccinated. VE against hospitalisation with H1N1/09 influenza after adjusting for age, medical comorbidities and pregnancy status was estimated at 49% (95% CI: 13%, 70%). Influenza vaccination was associated with a reduction in hospitalisation caused by H1N1/09 influenza in the 2010 southern hemisphere winter season.
AB - We aimed to estimate the effectiveness of H1N1/09 containing influenza vaccines against hospitalization from influenza in Australia. We performed a test-negative case control study in patients hospitalized in 15 sentinel Australian hospitals between March and November 2010, comparing influenza vaccination (H1N1/09 monovalent or 2010 seasonal trivalent) in hospitalized patients with PCR-confirmed influenza compared to PCR-negative controls. Between March and November 2010, 1169 hospitalized patients were tested for suspected influenza, of which influenza vaccine status was ascertained in 165/238 patients with H1N1/09 influenza, 40/64 with seasonal influenza and 558/867 test negative controls; 24% of H1N1/09 cases, 43% of seasonal influenza cases and 54% of controls were vaccinated. VE against hospitalisation with H1N1/09 influenza after adjusting for age, medical comorbidities and pregnancy status was estimated at 49% (95% CI: 13%, 70%). Influenza vaccination was associated with a reduction in hospitalisation caused by H1N1/09 influenza in the 2010 southern hemisphere winter season.
KW - Case control studies
KW - Influenza complications
KW - Influenza vaccines
UR - http://www.scopus.com/inward/record.url?scp=80053437598&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2011.07.087
DO - 10.1016/j.vaccine.2011.07.087
M3 - Article
SN - 0264-410X
VL - 29
SP - 7320
EP - 7325
JO - Vaccine
JF - Vaccine
IS - 43
ER -
