Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: A test-negative case control study

Allen Cheng; Tom Kotsimbos; Heath Kelly; Louis Irving; Simon Bowler; Simon Brown; Mark Holmes; Christine Jenkins, Jenkins; Philip Thompson; Grahame Simpson; Richard Wood-Baker; Sanjaya Senanayake; Stephen Brady; David Paterson; Peter Wark; John Upham; Tony Korman; Dominic Dwyer; Grant Waterer; P Kelly

doi:10.1016/j.vaccine.2011.07.087

Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: A test-negative case control study

Allen Cheng, Tom Kotsimbos, Heath Kelly, Louis Irving, Simon Bowler, Simon Brown, Mark Holmes, Christine Jenkins, Jenkins, Philip Thompson, Grahame Simpson, Richard Wood-Baker, Sanjaya Senanayake, Stephen Brady, David Paterson, Peter Wark, John Upham, Tony Korman, Dominic Dwyer, Grant Waterer, P Kelly

Research output: Contribution to journal › Article

35 Citations (Scopus)

Abstract

We aimed to estimate the effectiveness of H1N1/09 containing influenza vaccines against hospitalization from influenza in Australia. We performed a test-negative case control study in patients hospitalized in 15 sentinel Australian hospitals between March and November 2010, comparing influenza vaccination (H1N1/09 monovalent or 2010 seasonal trivalent) in hospitalized patients with PCR-confirmed influenza compared to PCR-negative controls. Between March and November 2010, 1169 hospitalized patients were tested for suspected influenza, of which influenza vaccine status was ascertained in 165/238 patients with H1N1/09 influenza, 40/64 with seasonal influenza and 558/867 test negative controls; 24% of H1N1/09 cases, 43% of seasonal influenza cases and 54% of controls were vaccinated. VE against hospitalisation with H1N1/09 influenza after adjusting for age, medical comorbidities and pregnancy status was estimated at 49% (95% CI: 13%, 70%). Influenza vaccination was associated with a reduction in hospitalisation caused by H1N1/09 influenza in the 2010 southern hemisphere winter season.

Original language	English
Pages (from-to)	7320-7325
Number of pages	6
Journal	Vaccine
Volume	29
Issue number	43
DOIs	https://doi.org/10.1016/j.vaccine.2011.07.087
Publication status	Published - 6 Oct 2011

Keywords

Case control studies
Influenza complications
Influenza vaccines

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10.1016/j.vaccine.2011.07.087

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Cheng, A., Kotsimbos, T., Kelly, H., Irving, L., Bowler, S., Brown, S., Holmes, M., Jenkins, C. J., Thompson, P., Simpson, G., Wood-Baker, R., Senanayake, S., Brady, S., Paterson, D., Wark, P., Upham, J., Korman, T., Dwyer, D., Waterer, G., & Kelly, P. (2011). Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: A test-negative case control study. Vaccine, 29(43), 7320-7325. https://doi.org/10.1016/j.vaccine.2011.07.087

Cheng, Allen ; Kotsimbos, Tom ; Kelly, Heath ; Irving, Louis ; Bowler, Simon ; Brown, Simon ; Holmes, Mark ; Jenkins, Christine Jenkins, ; Thompson, Philip ; Simpson, Grahame ; Wood-Baker, Richard ; Senanayake, Sanjaya ; Brady, Stephen ; Paterson, David ; Wark, Peter ; Upham, John ; Korman, Tony ; Dwyer, Dominic ; Waterer, Grant ; Kelly, P. / Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: A test-negative case control study. In: Vaccine. 2011 ; Vol. 29, No. 43. pp. 7320-7325.

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title = "Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: A test-negative case control study",

abstract = "We aimed to estimate the effectiveness of H1N1/09 containing influenza vaccines against hospitalization from influenza in Australia. We performed a test-negative case control study in patients hospitalized in 15 sentinel Australian hospitals between March and November 2010, comparing influenza vaccination (H1N1/09 monovalent or 2010 seasonal trivalent) in hospitalized patients with PCR-confirmed influenza compared to PCR-negative controls. Between March and November 2010, 1169 hospitalized patients were tested for suspected influenza, of which influenza vaccine status was ascertained in 165/238 patients with H1N1/09 influenza, 40/64 with seasonal influenza and 558/867 test negative controls; 24% of H1N1/09 cases, 43% of seasonal influenza cases and 54% of controls were vaccinated. VE against hospitalisation with H1N1/09 influenza after adjusting for age, medical comorbidities and pregnancy status was estimated at 49% (95% CI: 13%, 70%). Influenza vaccination was associated with a reduction in hospitalisation caused by H1N1/09 influenza in the 2010 southern hemisphere winter season.",

keywords = "Case control studies, Influenza complications, Influenza vaccines",

author = "Allen Cheng and Tom Kotsimbos and Heath Kelly and Louis Irving and Simon Bowler and Simon Brown and Mark Holmes and Jenkins, {Christine Jenkins,} and Philip Thompson and Grahame Simpson and Richard Wood-Baker and Sanjaya Senanayake and Stephen Brady and David Paterson and Peter Wark and John Upham and Tony Korman and Dominic Dwyer and Grant Waterer and P Kelly",

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doi = "10.1016/j.vaccine.2011.07.087",

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Cheng, A, Kotsimbos, T, Kelly, H, Irving, L, Bowler, S, Brown, S, Holmes, M, Jenkins, CJ, Thompson, P, Simpson, G, Wood-Baker, R, Senanayake, S, Brady, S, Paterson, D, Wark, P, Upham, J, Korman, T, Dwyer, D, Waterer, G & Kelly, P 2011, 'Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: A test-negative case control study', Vaccine, vol. 29, no. 43, pp. 7320-7325. https://doi.org/10.1016/j.vaccine.2011.07.087

Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: A test-negative case control study. / Cheng, Allen; Kotsimbos, Tom; Kelly, Heath; Irving, Louis; Bowler, Simon; Brown, Simon; Holmes, Mark; Jenkins, Christine Jenkins,; Thompson, Philip; Simpson, Grahame; Wood-Baker, Richard; Senanayake, Sanjaya; Brady, Stephen; Paterson, David; Wark, Peter; Upham, John; Korman, Tony; Dwyer, Dominic; Waterer, Grant; Kelly, P.

In: Vaccine, Vol. 29, No. 43, 06.10.2011, p. 7320-7325.

Research output: Contribution to journal › Article

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AU - Brady, Stephen

AU - Paterson, David

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