TY - JOUR
T1 - Effectiveness of honey on radiation-induced oral mucositis, time to mucositis, weight loss, and treatment interruptions among patients with head and neck malignancies
T2 - A meta-analysis and systematic review of literature
AU - Co, Jayson L.
AU - Mejia, Michael Benedict A.
AU - Que, Jocelyn C.
AU - Dizon, Janine Margarita R.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - BackgroundMucositis is a disabling effect of radiotherapy in head and neck cancers. There is no current standard on management of radiation-induced mucositis. Honey has been shown to reduce radiation-induced mucositis.MethodsA systematic review and meta-analysis were undertaken to assess the ability of honey in reducing the severity of oral mucositis, time to mucositis, weight loss, and treatment interruptions.ResultsEight studies were included and showed that honey was significantly better in lowering the risk for treatment interruptions, weight loss, and delaying time to mucositis, but not severity of mucositis.ConclusionThere is current evidence that honey is beneficial for patients with head and neck cancers by decreasing treatment interruptions, weight loss, and delaying the onset of oral mucositis, but not in decreasing peak mucositis score. In light of the results, honey is a reasonable treatment for radiation-induced mucositis, but more randomized clinical trials (RCTs) should be done.
AB - BackgroundMucositis is a disabling effect of radiotherapy in head and neck cancers. There is no current standard on management of radiation-induced mucositis. Honey has been shown to reduce radiation-induced mucositis.MethodsA systematic review and meta-analysis were undertaken to assess the ability of honey in reducing the severity of oral mucositis, time to mucositis, weight loss, and treatment interruptions.ResultsEight studies were included and showed that honey was significantly better in lowering the risk for treatment interruptions, weight loss, and delaying time to mucositis, but not severity of mucositis.ConclusionThere is current evidence that honey is beneficial for patients with head and neck cancers by decreasing treatment interruptions, weight loss, and delaying the onset of oral mucositis, but not in decreasing peak mucositis score. In light of the results, honey is a reasonable treatment for radiation-induced mucositis, but more randomized clinical trials (RCTs) should be done.
KW - Head and neck cancers
KW - Honey
KW - Radiation-induced mucositis
KW - Radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=84963620463&partnerID=8YFLogxK
U2 - 10.1002/hed.24431
DO - 10.1002/hed.24431
M3 - Review article
C2 - 27028991
AN - SCOPUS:84963620463
VL - 38
SP - 1119
EP - 1128
JO - Head and Neck
JF - Head and Neck
SN - 1043-3074
IS - 7
ER -