Effectiveness of receiving genetic risk information for cardiovascular disease on health behaviors, psychological responses, and associated risk factor modification in individuals: a systematic review protocol

Ruofei (Trophy) Chen; Vincent Pearson; Orathai Suebkinorn; Lemma Bulto; Anderson Alice; Adam J. Nelson; Sophia Zoungas; Stephen Nicholls; Robyn A. Clark

doi:10.11124/JBIES-23-00313

Effectiveness of receiving genetic risk information for cardiovascular disease on health behaviors, psychological responses, and associated risk factor modification in individuals: a systematic review protocol

Ruofei (Trophy) Chen, Vincent Pearson, Orathai Suebkinorn, Lemma Bulto, Anderson Alice, Adam J. Nelson, Sophia Zoungas, Stephen Nicholls, Robyn A. Clark

Research output: Contribution to journal › Review article › peer-review

Abstract

Objective: This review aims to assess the effectiveness of receiving cardiovascular disease (CVD) genetic risk information on individual health behaviors, psychological responses, and risk factor modification.

Introduction: Advancements in genomics have identified strong genetic predispositions for CVD, leading to the development of CVD genetic risk information. Integrating genetic risk information into clinical practice shows promise in predicting CVD risk and facilitating multifactorial management.

Inclusion criteria: This review will focus on randomized controlled trials assessing individual responses to CVD genetic risk information. Participants will be adults aged 18 or older, either with or without CVD. The review will compare the effectiveness of receiving genetic risk information with receiving traditional risk information or no risk information, assessing outcomes such as health behaviors, psychological responses, and risk factor modification.

Methods: Cochrane CENTRAL, MEDLINE, Embase, and Emcare will be searched for relevant studies. Current or unpublished trials will be searched for in ClinicalTrials.gov and World Health Organization International Clinical Trials Registry Platform. Articles will be screened and assessed for inclusion by 2 independent reviewers. Methodological quality will be assessed using the standardized instrument from JBI. Data will be extracted and synthesized according to the objectives of the review. If data are sufficient, a meta-analysis will be conducted; otherwise, the findings will be presented in narrative format, including tables and figures. The certainty of evidence will be assessed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach.

Review registration: PROSPERO CRD42023390876.

Original language	English
Pages (from-to)	2567-2576
Number of pages	10
Journal	JBI Evidence Synthesis
Volume	22
Issue number	12
Early online date	3 Sept 2024
DOIs	https://doi.org/10.11124/JBIES-23-00313
Publication status	Published - Dec 2024

Keywords

cardiovascular disease
genetic risk
polygenic risk
risk factor modification

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Effectiveness of alternative exercises in cardiac rehabilitation for program completion and outcomes in women with or at high risk of cardiovascular disease: a systematic review and meta-analysis
Suebkinorn, O., Ramos, J. S., Grace, S. L., Gebremichael, L. G., Bulamu, N. B., Pinero de Plaza, M. A., Dafny, H. A., Pearson, V., Bulto, L. N., Chen, R. T., Rattanakanokchai, S., Ghisi, G. L. M., Marin, T., Nesbitt, K., Gulyani, A., Hines, S., Dalleck, L. C., Hendriks, J. M., Clark, R. A. & Beleigoli, A., Jun 2025, In: JBI evidence synthesis. 23, 6, p. 1041-1076 36 p.
Research output: Contribution to journal › Review article › peer-review

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Chen, R., Pearson, V., Suebkinorn, O., Bulto, L., Alice, A., Nelson, A. J., Zoungas, S., Nicholls, S., & Clark, R. A. (2024). Effectiveness of receiving genetic risk information for cardiovascular disease on health behaviors, psychological responses, and associated risk factor modification in individuals: a systematic review protocol. JBI Evidence Synthesis, 22(12), 2567-2576. https://doi.org/10.11124/JBIES-23-00313

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title = "Effectiveness of receiving genetic risk information for cardiovascular disease on health behaviors, psychological responses, and associated risk factor modification in individuals: a systematic review protocol",

abstract = "Objective: This review aims to assess the effectiveness of receiving cardiovascular disease (CVD) genetic risk information on individual health behaviors, psychological responses, and risk factor modification. Introduction: Advancements in genomics have identified strong genetic predispositions for CVD, leading to the development of CVD genetic risk information. Integrating genetic risk information into clinical practice shows promise in predicting CVD risk and facilitating multifactorial management.Inclusion criteria: This review will focus on randomized controlled trials assessing individual responses to CVD genetic risk information. Participants will be adults aged 18 or older, either with or without CVD. The review will compare the effectiveness of receiving genetic risk information with receiving traditional risk information or no risk information, assessing outcomes such as health behaviors, psychological responses, and risk factor modification. Methods: Cochrane CENTRAL, MEDLINE, Embase, and Emcare will be searched for relevant studies. Current or unpublished trials will be searched for in ClinicalTrials.gov and World Health Organization International Clinical Trials Registry Platform. Articles will be screened and assessed for inclusion by 2 independent reviewers. Methodological quality will be assessed using the standardized instrument from JBI. Data will be extracted and synthesized according to the objectives of the review. If data are sufficient, a meta-analysis will be conducted; otherwise, the findings will be presented in narrative format, including tables and figures. The certainty of evidence will be assessed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Review registration: PROSPERO CRD42023390876.",

keywords = "cardiovascular disease, genetic risk, polygenic risk, risk factor modification",

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language = "English",

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Chen, R, Pearson, V, Suebkinorn, O , Bulto, L, Alice, A, Nelson, AJ, Zoungas, S, Nicholls, S & Clark, RA 2024, 'Effectiveness of receiving genetic risk information for cardiovascular disease on health behaviors, psychological responses, and associated risk factor modification in individuals: a systematic review protocol', JBI Evidence Synthesis, vol. 22, no. 12, pp. 2567-2576. https://doi.org/10.11124/JBIES-23-00313

Effectiveness of receiving genetic risk information for cardiovascular disease on health behaviors, psychological responses, and associated risk factor modification in individuals: a systematic review protocol. / Chen, Ruofei (Trophy); Pearson, Vincent; Suebkinorn, Orathai et al.
In: JBI Evidence Synthesis, Vol. 22, No. 12, 12.2024, p. 2567-2576.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Effectiveness of receiving genetic risk information for cardiovascular disease on health behaviors, psychological responses, and associated risk factor modification in individuals

T2 - a systematic review protocol

AU - Chen, Ruofei (Trophy)

AU - Pearson, Vincent

AU - Suebkinorn, Orathai

AU - Bulto, Lemma

AU - Alice, Anderson

AU - Nelson, Adam J.

AU - Zoungas, Sophia

AU - Nicholls, Stephen

AU - Clark, Robyn A.

PY - 2024/12

Y1 - 2024/12

N2 - Objective: This review aims to assess the effectiveness of receiving cardiovascular disease (CVD) genetic risk information on individual health behaviors, psychological responses, and risk factor modification. Introduction: Advancements in genomics have identified strong genetic predispositions for CVD, leading to the development of CVD genetic risk information. Integrating genetic risk information into clinical practice shows promise in predicting CVD risk and facilitating multifactorial management.Inclusion criteria: This review will focus on randomized controlled trials assessing individual responses to CVD genetic risk information. Participants will be adults aged 18 or older, either with or without CVD. The review will compare the effectiveness of receiving genetic risk information with receiving traditional risk information or no risk information, assessing outcomes such as health behaviors, psychological responses, and risk factor modification. Methods: Cochrane CENTRAL, MEDLINE, Embase, and Emcare will be searched for relevant studies. Current or unpublished trials will be searched for in ClinicalTrials.gov and World Health Organization International Clinical Trials Registry Platform. Articles will be screened and assessed for inclusion by 2 independent reviewers. Methodological quality will be assessed using the standardized instrument from JBI. Data will be extracted and synthesized according to the objectives of the review. If data are sufficient, a meta-analysis will be conducted; otherwise, the findings will be presented in narrative format, including tables and figures. The certainty of evidence will be assessed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Review registration: PROSPERO CRD42023390876.

AB - Objective: This review aims to assess the effectiveness of receiving cardiovascular disease (CVD) genetic risk information on individual health behaviors, psychological responses, and risk factor modification. Introduction: Advancements in genomics have identified strong genetic predispositions for CVD, leading to the development of CVD genetic risk information. Integrating genetic risk information into clinical practice shows promise in predicting CVD risk and facilitating multifactorial management.Inclusion criteria: This review will focus on randomized controlled trials assessing individual responses to CVD genetic risk information. Participants will be adults aged 18 or older, either with or without CVD. The review will compare the effectiveness of receiving genetic risk information with receiving traditional risk information or no risk information, assessing outcomes such as health behaviors, psychological responses, and risk factor modification. Methods: Cochrane CENTRAL, MEDLINE, Embase, and Emcare will be searched for relevant studies. Current or unpublished trials will be searched for in ClinicalTrials.gov and World Health Organization International Clinical Trials Registry Platform. Articles will be screened and assessed for inclusion by 2 independent reviewers. Methodological quality will be assessed using the standardized instrument from JBI. Data will be extracted and synthesized according to the objectives of the review. If data are sufficient, a meta-analysis will be conducted; otherwise, the findings will be presented in narrative format, including tables and figures. The certainty of evidence will be assessed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Review registration: PROSPERO CRD42023390876.

KW - cardiovascular disease

KW - genetic risk

KW - polygenic risk

KW - risk factor modification

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U2 - 10.11124/JBIES-23-00313

DO - 10.11124/JBIES-23-00313

M3 - Review article

SN - 2689-8381

VL - 22

SP - 2567

EP - 2576

JO - JBI Evidence Synthesis

JF - JBI Evidence Synthesis

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ER -

Chen R, Pearson V, Suebkinorn O , Bulto L, Alice A, Nelson AJ et al. Effectiveness of receiving genetic risk information for cardiovascular disease on health behaviors, psychological responses, and associated risk factor modification in individuals: a systematic review protocol. JBI Evidence Synthesis. 2024 Dec;22(12):2567-2576. Epub 2024 Sept 3. doi: 10.11124/JBIES-23-00313

Effectiveness of receiving genetic risk information for cardiovascular disease on health behaviors, psychological responses, and associated risk factor modification in individuals: a systematic review protocol

Abstract

Keywords

UN SDGs

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Research output

Effectiveness of alternative exercises in cardiac rehabilitation for program completion and outcomes in women with or at high risk of cardiovascular disease: a systematic review and meta-analysis

Cite this