Effects of aging on vasopressin secretion, water excretion, and thirst in man

J. G.G. Ledingham; M. J. Crowe; M. L. Forsling; P. A. Phillips; B. J. Rolls

Effects of aging on vasopressin secretion, water excretion, and thirst in man

J. G.G. Ledingham, M. J. Crowe, M. L. Forsling, P. A. Phillips, B. J. Rolls

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33 Citations (Scopus)

Abstract

Disorders of water balance are common among elderly patients. A number of factors may contribute. Osmoreceptor-mediated release of AVP is increased, but the response to volume stimuli may be reduced. The capacity of the kidney to concentrate urine is reduced by age, but this impairment cannot be correlated with coincident loss of glomerular filtration (GFR); there may rather be a failure of cAMP response to AVP in aging kidneys. Free water clearance is reduced in the old in proportion to the loss of GFR. Thirst mechanisms are also significantly impaired in healthy as well as sick old people. This combination of factors renders old people particularly liable to develop disorders of water homeostasis during episodes of acute or chronic ill health.

Original language	English
Pages (from-to)	S90-S92
Number of pages	3
Journal	Kidney International
Volume	32
Issue number	SUPPL. 21
Publication status	Published - 1987
Externally published	Yes

Cite this

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abstract = "Disorders of water balance are common among elderly patients. A number of factors may contribute. Osmoreceptor-mediated release of AVP is increased, but the response to volume stimuli may be reduced. The capacity of the kidney to concentrate urine is reduced by age, but this impairment cannot be correlated with coincident loss of glomerular filtration (GFR); there may rather be a failure of cAMP response to AVP in aging kidneys. Free water clearance is reduced in the old in proportion to the loss of GFR. Thirst mechanisms are also significantly impaired in healthy as well as sick old people. This combination of factors renders old people particularly liable to develop disorders of water homeostasis during episodes of acute or chronic ill health.",

author = "Ledingham, {J. G.G.} and Crowe, {M. J.} and Forsling, {M. L.} and Phillips, {P. A.} and Rolls, {B. J.}",

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AU - Ledingham, J. G.G.

AU - Crowe, M. J.

AU - Forsling, M. L.

AU - Phillips, P. A.

AU - Rolls, B. J.

PY - 1987

Y1 - 1987

N2 - Disorders of water balance are common among elderly patients. A number of factors may contribute. Osmoreceptor-mediated release of AVP is increased, but the response to volume stimuli may be reduced. The capacity of the kidney to concentrate urine is reduced by age, but this impairment cannot be correlated with coincident loss of glomerular filtration (GFR); there may rather be a failure of cAMP response to AVP in aging kidneys. Free water clearance is reduced in the old in proportion to the loss of GFR. Thirst mechanisms are also significantly impaired in healthy as well as sick old people. This combination of factors renders old people particularly liable to develop disorders of water homeostasis during episodes of acute or chronic ill health.

AB - Disorders of water balance are common among elderly patients. A number of factors may contribute. Osmoreceptor-mediated release of AVP is increased, but the response to volume stimuli may be reduced. The capacity of the kidney to concentrate urine is reduced by age, but this impairment cannot be correlated with coincident loss of glomerular filtration (GFR); there may rather be a failure of cAMP response to AVP in aging kidneys. Free water clearance is reduced in the old in proportion to the loss of GFR. Thirst mechanisms are also significantly impaired in healthy as well as sick old people. This combination of factors renders old people particularly liable to develop disorders of water homeostasis during episodes of acute or chronic ill health.

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VL - 32

SP - S90-S92

JO - Kidney International

JF - Kidney International

IS - SUPPL. 21

ER -

Effects of aging on vasopressin secretion, water excretion, and thirst in man

Abstract

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