Effects of clozapine for non-treatment-resistant patients with schizophrenia

Cherrie A. Galletly, C. Richard Clark, Alexander C. McFarlane, Darren L. Weber

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)


    Clozapine is generally used for patients meeting criteria for treatment resistance. In this study clozapine was given to 19 patients with schizophrenia who did not meet these criteria and whose symptoms were mild to moderate in severity. Clozapine was associated with significant improvement in positive and negative symptoms and quality of life. A more modest improvement on a range of tests of cognitive functioning was also noted. These results suggest that consideration should be given to broadening the usual criteria for patients' eligibility for clozapine treatment.

    Original languageEnglish
    Pages (from-to)101-103
    Number of pages3
    JournalPsychiatric Services
    Issue number1
    Publication statusPublished - Jan 1999


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