Effects of enalapril and hydrochlorothiazide on blood pressure, renin angiotensin system, and atrial natriuretic factor in essential hypertension: a double blind factorial cross over study

J. P. Chalmers, L. M.H. Wing, M. J. West, A. J.C. Bune, J. M. Elliott, M. J. Morris, M. D. Cain, J. R. Graham, D. O. Southgate

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The hypotensive and hormonal effects of the angiotensin converting enzyme (ACE) inhibitor enalapril (10 mg twice daily) were compared with those of hydrochlorothiazide (25 mg twice daily), with the two drugs in combination and with placebo in 21 patients with essential hypertension. For each patient there were four randomised double‐blind treatment phases, each of four weeks' duration, which comprised a 2 times 2 factorial experiment.

Original languageEnglish
Pages (from-to)475-480
Number of pages6
JournalAustralian and New Zealand Journal of Medicine
Volume16
Issue number4
DOIs
Publication statusPublished - Aug 1986
Externally publishedYes

Keywords

  • Angiotensin converting enzyme inhibitors
  • atrial natriuretic factor
  • blood pressure
  • enalapril
  • renin‐angiotensin system
  • thiazide diuretics

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