Abstract
The hypotensive and hormonal effects of the angiotensin converting enzyme (ACE) inhibitor enalapril (10 mg twice daily) were compared with those of hydrochlorothiazide (25 mg twice daily), with the two drugs in combination and with placebo in 21 patients with essential hypertension. For each patient there were four randomised double‐blind treatment phases, each of four weeks' duration, which comprised a 2 times 2 factorial experiment.
| Original language | English |
|---|---|
| Pages (from-to) | 475-480 |
| Number of pages | 6 |
| Journal | Australian and New Zealand Journal of Medicine |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 1986 |
| Externally published | Yes |
Keywords
- Angiotensin converting enzyme inhibitors
- atrial natriuretic factor
- blood pressure
- enalapril
- renin‐angiotensin system
- thiazide diuretics
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Chalmers, J. P., Wing, L. M. H., West, M. J., Bune, A. J. C., Elliott, J. M., Morris, M. J., Cain, M. D., Graham, J. R., & Southgate, D. O. (1986). Effects of enalapril and hydrochlorothiazide on blood pressure, renin angiotensin system, and atrial natriuretic factor in essential hypertension: a double blind factorial cross over study. Australian and New Zealand Journal of Medicine, 16(4), 475-480. https://doi.org/10.1111/j.1445-5994.1986.tb02014.x