Effects of enalapril and hydrochlorothiazide on blood pressure, renin angiotensin system, and atrial natriuretic factor in essential hypertension: a double blind factorial cross over study

J. P. Chalmers; L. M.H. Wing; M. J. West; A. J.C. Bune; J. M. Elliott; M. J. Morris; M. D. Cain; J. R. Graham; D. O. Southgate

doi:10.1111/j.1445-5994.1986.tb02014.x

Effects of enalapril and hydrochlorothiazide on blood pressure, renin angiotensin system, and atrial natriuretic factor in essential hypertension: a double blind factorial cross over study

J. P. Chalmers, L. M.H. Wing, M. J. West, A. J.C. Bune, J. M. Elliott, M. J. Morris, M. D. Cain, J. R. Graham, D. O. Southgate

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The hypotensive and hormonal effects of the angiotensin converting enzyme (ACE) inhibitor enalapril (10 mg twice daily) were compared with those of hydrochlorothiazide (25 mg twice daily), with the two drugs in combination and with placebo in 21 patients with essential hypertension. For each patient there were four randomised double‐blind treatment phases, each of four weeks' duration, which comprised a 2 times 2 factorial experiment.

Original language	English
Pages (from-to)	475-480
Number of pages	6
Journal	Australian and New Zealand Journal of Medicine
Volume	16
Issue number	4
DOIs	https://doi.org/10.1111/j.1445-5994.1986.tb02014.x
Publication status	Published - Aug 1986
Externally published	Yes

Keywords

Angiotensin converting enzyme inhibitors
atrial natriuretic factor
blood pressure
enalapril
renin‐angiotensin system
thiazide diuretics

Access to Document

10.1111/j.1445-5994.1986.tb02014.x

Cite this

Chalmers, J. P., Wing, L. M. H., West, M. J., Bune, A. J. C., Elliott, J. M., Morris, M. J., Cain, M. D., Graham, J. R., & Southgate, D. O. (1986). Effects of enalapril and hydrochlorothiazide on blood pressure, renin angiotensin system, and atrial natriuretic factor in essential hypertension: a double blind factorial cross over study. Australian and New Zealand Journal of Medicine, 16(4), 475-480. https://doi.org/10.1111/j.1445-5994.1986.tb02014.x

Chalmers, J. P. ; Wing, L. M.H. ; West, M. J. ; Bune, A. J.C. ; Elliott, J. M. ; Morris, M. J. ; Cain, M. D. ; Graham, J. R. ; Southgate, D. O. / Effects of enalapril and hydrochlorothiazide on blood pressure, renin angiotensin system, and atrial natriuretic factor in essential hypertension : a double blind factorial cross over study. In: Australian and New Zealand Journal of Medicine. 1986 ; Vol. 16, No. 4. pp. 475-480.

@article{38bafa4afbc846389f2311cebcbdc256,

title = "Effects of enalapril and hydrochlorothiazide on blood pressure, renin angiotensin system, and atrial natriuretic factor in essential hypertension: a double blind factorial cross over study",

abstract = "The hypotensive and hormonal effects of the angiotensin converting enzyme (ACE) inhibitor enalapril (10 mg twice daily) were compared with those of hydrochlorothiazide (25 mg twice daily), with the two drugs in combination and with placebo in 21 patients with essential hypertension. For each patient there were four randomised double‐blind treatment phases, each of four weeks' duration, which comprised a 2 times 2 factorial experiment.",

keywords = "Angiotensin converting enzyme inhibitors, atrial natriuretic factor, blood pressure, enalapril, renin‐angiotensin system, thiazide diuretics",

author = "Chalmers, {J. P.} and Wing, {L. M.H.} and West, {M. J.} and Bune, {A. J.C.} and Elliott, {J. M.} and Morris, {M. J.} and Cain, {M. D.} and Graham, {J. R.} and Southgate, {D. O.}",

year = "1986",

month = aug,

doi = "10.1111/j.1445-5994.1986.tb02014.x",

language = "English",

volume = "16",

pages = "475--480",

journal = "Internal Medicine Journal",

issn = "0004-8291",

publisher = "Wiley",

number = "4",

}

Chalmers, JP , Wing, LMH, West, MJ, Bune, AJC, Elliott, JM, Morris, MJ, Cain, MD, Graham, JR & Southgate, DO 1986, 'Effects of enalapril and hydrochlorothiazide on blood pressure, renin angiotensin system, and atrial natriuretic factor in essential hypertension: a double blind factorial cross over study', Australian and New Zealand Journal of Medicine, vol. 16, no. 4, pp. 475-480. https://doi.org/10.1111/j.1445-5994.1986.tb02014.x

Effects of enalapril and hydrochlorothiazide on blood pressure, renin angiotensin system, and atrial natriuretic factor in essential hypertension : a double blind factorial cross over study. / Chalmers, J. P.; Wing, L. M.H.; West, M. J.; Bune, A. J.C.; Elliott, J. M.; Morris, M. J.; Cain, M. D.; Graham, J. R.; Southgate, D. O.

In: Australian and New Zealand Journal of Medicine, Vol. 16, No. 4, 08.1986, p. 475-480.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effects of enalapril and hydrochlorothiazide on blood pressure, renin angiotensin system, and atrial natriuretic factor in essential hypertension

T2 - a double blind factorial cross over study

AU - Chalmers, J. P.

AU - Wing, L. M.H.

AU - West, M. J.

AU - Bune, A. J.C.

AU - Elliott, J. M.

AU - Morris, M. J.

AU - Cain, M. D.

AU - Graham, J. R.

AU - Southgate, D. O.

PY - 1986/8

Y1 - 1986/8

N2 - The hypotensive and hormonal effects of the angiotensin converting enzyme (ACE) inhibitor enalapril (10 mg twice daily) were compared with those of hydrochlorothiazide (25 mg twice daily), with the two drugs in combination and with placebo in 21 patients with essential hypertension. For each patient there were four randomised double‐blind treatment phases, each of four weeks' duration, which comprised a 2 times 2 factorial experiment.

AB - The hypotensive and hormonal effects of the angiotensin converting enzyme (ACE) inhibitor enalapril (10 mg twice daily) were compared with those of hydrochlorothiazide (25 mg twice daily), with the two drugs in combination and with placebo in 21 patients with essential hypertension. For each patient there were four randomised double‐blind treatment phases, each of four weeks' duration, which comprised a 2 times 2 factorial experiment.

KW - Angiotensin converting enzyme inhibitors

KW - atrial natriuretic factor

KW - blood pressure

KW - enalapril

KW - renin‐angiotensin system

KW - thiazide diuretics

UR - http://www.scopus.com/inward/record.url?scp=0022998919&partnerID=8YFLogxK

U2 - 10.1111/j.1445-5994.1986.tb02014.x

DO - 10.1111/j.1445-5994.1986.tb02014.x

M3 - Article

AN - SCOPUS:0022998919

VL - 16

SP - 475

EP - 480

JO - Internal Medicine Journal

JF - Internal Medicine Journal

SN - 0004-8291

IS - 4

ER -

Chalmers JP , Wing LMH, West MJ, Bune AJC, Elliott JM, Morris MJ et al. Effects of enalapril and hydrochlorothiazide on blood pressure, renin angiotensin system, and atrial natriuretic factor in essential hypertension: a double blind factorial cross over study. Australian and New Zealand Journal of Medicine. 1986 Aug;16(4):475-480. https://doi.org/10.1111/j.1445-5994.1986.tb02014.x

Effects of enalapril and hydrochlorothiazide on blood pressure, renin angiotensin system, and atrial natriuretic factor in essential hypertension: a double blind factorial cross over study

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this