Effects of enalapril and hydrochlorothiazide on blood pressure, renin angiotensin system, and atrial natriuretic factor in essential hypertension: a double blind factorial cross over study

J. P. Chalmers; L. M.H. Wing; M. J. West; A. J.C. Bune; J. M. Elliott; M. J. Morris; M. D. Cain; J. R. Graham; D. O. Southgate

doi:10.1111/j.1445-5994.1986.tb02014.x

Effects of enalapril and hydrochlorothiazide on blood pressure, renin angiotensin system, and atrial natriuretic factor in essential hypertension: a double blind factorial cross over study

J. P. Chalmers, L. M.H. Wing, M. J. West, A. J.C. Bune, J. M. Elliott, M. J. Morris, M. D. Cain, J. R. Graham, D. O. Southgate

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

The hypotensive and hormonal effects of the angiotensin converting enzyme (ACE) inhibitor enalapril (10 mg twice daily) were compared with those of hydrochlorothiazide (25 mg twice daily), with the two drugs in combination and with placebo in 21 patients with essential hypertension. For each patient there were four randomised double‐blind treatment phases, each of four weeks' duration, which comprised a 2 times 2 factorial experiment.

Original language	English
Pages (from-to)	475-480
Number of pages	6
Journal	Australian and New Zealand Journal of Medicine
Volume	16
Issue number	4
DOIs	https://doi.org/10.1111/j.1445-5994.1986.tb02014.x
Publication status	Published - Aug 1986
Externally published	Yes

Keywords

Angiotensin converting enzyme inhibitors
atrial natriuretic factor
blood pressure
enalapril
renin‐angiotensin system
thiazide diuretics

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Chalmers, J. P., Wing, L. M. H., West, M. J., Bune, A. J. C., Elliott, J. M., Morris, M. J., Cain, M. D., Graham, J. R., & Southgate, D. O. (1986). Effects of enalapril and hydrochlorothiazide on blood pressure, renin angiotensin system, and atrial natriuretic factor in essential hypertension: a double blind factorial cross over study. Australian and New Zealand Journal of Medicine, 16(4), 475-480. https://doi.org/10.1111/j.1445-5994.1986.tb02014.x

Chalmers, J. P. ; Wing, L. M.H. ; West, M. J. ; Bune, A. J.C. ; Elliott, J. M. ; Morris, M. J. ; Cain, M. D. ; Graham, J. R. ; Southgate, D. O. / Effects of enalapril and hydrochlorothiazide on blood pressure, renin angiotensin system, and atrial natriuretic factor in essential hypertension : a double blind factorial cross over study. In: Australian and New Zealand Journal of Medicine. 1986 ; Vol. 16, No. 4. pp. 475-480.

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abstract = "The hypotensive and hormonal effects of the angiotensin converting enzyme (ACE) inhibitor enalapril (10 mg twice daily) were compared with those of hydrochlorothiazide (25 mg twice daily), with the two drugs in combination and with placebo in 21 patients with essential hypertension. For each patient there were four randomised double‐blind treatment phases, each of four weeks' duration, which comprised a 2 times 2 factorial experiment.",

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Chalmers, JP , Wing, LMH, West, MJ, Bune, AJC, Elliott, JM, Morris, MJ, Cain, MD, Graham, JR & Southgate, DO 1986, 'Effects of enalapril and hydrochlorothiazide on blood pressure, renin angiotensin system, and atrial natriuretic factor in essential hypertension: a double blind factorial cross over study', Australian and New Zealand Journal of Medicine, vol. 16, no. 4, pp. 475-480. https://doi.org/10.1111/j.1445-5994.1986.tb02014.x

Effects of enalapril and hydrochlorothiazide on blood pressure, renin angiotensin system, and atrial natriuretic factor in essential hypertension : a double blind factorial cross over study. / Chalmers, J. P.; Wing, L. M.H.; West, M. J.; Bune, A. J.C.; Elliott, J. M.; Morris, M. J.; Cain, M. D.; Graham, J. R.; Southgate, D. O.

In: Australian and New Zealand Journal of Medicine, Vol. 16, No. 4, 08.1986, p. 475-480.

Research output: Contribution to journal › Article › peer-review

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Chalmers JP , Wing LMH, West MJ, Bune AJC, Elliott JM, Morris MJ et al. Effects of enalapril and hydrochlorothiazide on blood pressure, renin angiotensin system, and atrial natriuretic factor in essential hypertension: a double blind factorial cross over study. Australian and New Zealand Journal of Medicine. 1986 Aug;16(4):475-480. https://doi.org/10.1111/j.1445-5994.1986.tb02014.x