Abstract
1. We studied the effects of an intravenous bolus of endothelin‐1 on arterial pressure and myocardial contractility in the conscious rabbit. 2. Endothelin produced an initial fall in arterial pressure accompanied by an increase in heart rate. This was followed by a dose‐dependent increase in arterial pressure, peaking about 7 min after injection, accompanied by a reciprocal fall in heart rate. 3. Left ventricular rate of change of pressure (LV dP/dt) increased with endothelin except at higher doses (0.8 and 1.6 nmol/kg), where in some animals it decreased.
| Original language | English |
|---|---|
| Pages (from-to) | 315-318 |
| Number of pages | 4 |
| Journal | Clinical and Experimental Pharmacology and Physiology |
| Volume | 18 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 1991 |
Keywords
- conscious normotensive rabbit
- endothelin
- heart rate
- left ventricular dP/dt
- mean arterial pressure
- myocardial contractility