EFFECTS OF ENDOTHELIN‐1 ON ARTERIAL PRESSURE AND MYOCARDIAL CONTRACTILITY IN THE CONSCIOUS NORMOTENSIVE RABBIT

P. Roberts‐Thomson, R. J. McRitchie, J. P. Chalmers

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    1. We studied the effects of an intravenous bolus of endothelin‐1 on arterial pressure and myocardial contractility in the conscious rabbit. 2. Endothelin produced an initial fall in arterial pressure accompanied by an increase in heart rate. This was followed by a dose‐dependent increase in arterial pressure, peaking about 7 min after injection, accompanied by a reciprocal fall in heart rate. 3. Left ventricular rate of change of pressure (LV dP/dt) increased with endothelin except at higher doses (0.8 and 1.6 nmol/kg), where in some animals it decreased.

    Original languageEnglish
    Pages (from-to)315-318
    Number of pages4
    JournalClinical and Experimental Pharmacology and Physiology
    Volume18
    Issue number5
    DOIs
    Publication statusPublished - May 1991

    Keywords

    • conscious normotensive rabbit
    • endothelin
    • heart rate
    • left ventricular dP/dt
    • mean arterial pressure
    • myocardial contractility

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