Effects of four thrombolytic regimens in elderly patients

I. Straznicky; H. D. White; C. B. Granger; P. E. Aylward; G. I. Barbash; E. J. Topol; R. M. Califf

Effects of four thrombolytic regimens in elderly patients

I. Straznicky, H. D. White, C. B. Granger, P. E. Aylward, G. I. Barbash, E. J. Topol, R. M. Califf

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

The relationship between outcome and age for patients with acute myocardial infarction who are given thrombolytic therapy was analyzed in a population of 41,021 infarction patients randomly assigned to one of four thrombolytic treatment regimens. Increasing age was associated with increasing rates of mortality and hemorrhagic complications, regardless of treatment regimen. Use of tissue plasminogen activator was associated with increasing rates of hemorrhagic stroke in the elderly. However, even after this adverse effect was taken into account, for patients aged less than 85 years therapy with accelerated tissue plasminogen activator was associated with the greatest reduction in the combined rate of death and disabling stroke.

Original language	English
Pages (from-to)	22-28
Number of pages	7
Journal	Cardiology Review
Volume	15
Issue number	1
Publication status	Published - 13 Jul 1998

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AU - Straznicky, I.

AU - White, H. D.

AU - Granger, C. B.

AU - Aylward, P. E.

AU - Barbash, G. I.

AU - Topol, E. J.

AU - Califf, R. M.

PY - 1998/7/13

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N2 - The relationship between outcome and age for patients with acute myocardial infarction who are given thrombolytic therapy was analyzed in a population of 41,021 infarction patients randomly assigned to one of four thrombolytic treatment regimens. Increasing age was associated with increasing rates of mortality and hemorrhagic complications, regardless of treatment regimen. Use of tissue plasminogen activator was associated with increasing rates of hemorrhagic stroke in the elderly. However, even after this adverse effect was taken into account, for patients aged less than 85 years therapy with accelerated tissue plasminogen activator was associated with the greatest reduction in the combined rate of death and disabling stroke.

AB - The relationship between outcome and age for patients with acute myocardial infarction who are given thrombolytic therapy was analyzed in a population of 41,021 infarction patients randomly assigned to one of four thrombolytic treatment regimens. Increasing age was associated with increasing rates of mortality and hemorrhagic complications, regardless of treatment regimen. Use of tissue plasminogen activator was associated with increasing rates of hemorrhagic stroke in the elderly. However, even after this adverse effect was taken into account, for patients aged less than 85 years therapy with accelerated tissue plasminogen activator was associated with the greatest reduction in the combined rate of death and disabling stroke.

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ER -

Effects of four thrombolytic regimens in elderly patients

Abstract

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