TY - JOUR
T1 - Effects of mitochondria concentration and age, energy and inhibitors of mitochondrial anion transport on malate transport in isolated rat heart mitochondria
AU - Barritt, Gregory J.
PY - 1978
Y1 - 1978
N2 - 1. 1. The rate and extent of exchange of external [14C]malate with endogenous counter ions in isolated rat heart mitochondria was found to depend markedly on the concentration and age of the isolated mitochondria. 2. 2. Ascorbic acid plus tetramethylphenylenediamine, or ATP stimulated malate exchange at low concentrations of mitochondria (0.2-0.8 mg protein per ml) but caused inhibition at higher concentrations. 3. 3. The rate of malate exchange was partially inhibited by atractyloside and benzene- 1,2,3-tricarboxylate, completely inhibited by 2-phenylsuccinate, 2-benzylmalonate and high concentrations of mersalyl, and stimulated by N-ethylmaleimide.
AB - 1. 1. The rate and extent of exchange of external [14C]malate with endogenous counter ions in isolated rat heart mitochondria was found to depend markedly on the concentration and age of the isolated mitochondria. 2. 2. Ascorbic acid plus tetramethylphenylenediamine, or ATP stimulated malate exchange at low concentrations of mitochondria (0.2-0.8 mg protein per ml) but caused inhibition at higher concentrations. 3. 3. The rate of malate exchange was partially inhibited by atractyloside and benzene- 1,2,3-tricarboxylate, completely inhibited by 2-phenylsuccinate, 2-benzylmalonate and high concentrations of mersalyl, and stimulated by N-ethylmaleimide.
UR - http://www.scopus.com/inward/record.url?scp=0017821199&partnerID=8YFLogxK
U2 - 10.1016/0020-711X(78)90104-0
DO - 10.1016/0020-711X(78)90104-0
M3 - Article
C2 - 566683
AN - SCOPUS:0017821199
SN - 0020-711X
VL - 9
SP - 317
EP - 322
JO - International Journal of Biochemistry
JF - International Journal of Biochemistry
IS - 5
ER -