EFFECTS OF NEUROPEPTIDE Y ON LEFT VENTRICULAR FUNCTION IN THE CONSCIOUS RABBIT

R. B. Minson, R. J. McRitchie, J. P. Chalmers

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

1. Changes in arterial pressure, heart rate and left ventricular contractility induced by intravenous injections of neuropeptide Y (NPY; 1–30 μg/kg) were studied in the conscious rabbit. 2. NPY has a brief pressor effect associated with a bradycardia, an increase in left ventricular end diastolic pressure, and a prolonged fall in peak left ventricular dP/dt (LVdP/dt). 3. The haemodynamic changes increase substantially with increasing doses up to 10 μg/kg. Beyond 10 μg/kg there are only slight effects on heart rate or peak LV dP/dt.

Original languageEnglish
Pages (from-to)263-266
Number of pages4
JournalClinical and Experimental Pharmacology and Physiology
Volume14
Issue number3
DOIs
Publication statusPublished - Mar 1987
Externally publishedYes

Keywords

  • arterial pressure
  • baroreflexes
  • conscious rabbit
  • heart rate
  • left ventricular pressure
  • myocardial contractility
  • neuropeptide Y

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