EFFECTS OF NEUROPEPTIDE Y ON LEFT VENTRICULAR FUNCTION IN THE CONSCIOUS RABBIT

R. B. Minson; R. J. McRitchie; J. P. Chalmers

doi:10.1111/j.1440-1681.1987.tb00387.x

EFFECTS OF NEUROPEPTIDE Y ON LEFT VENTRICULAR FUNCTION IN THE CONSCIOUS RABBIT

R. B. Minson, R. J. McRitchie, J. P. Chalmers

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

1. Changes in arterial pressure, heart rate and left ventricular contractility induced by intravenous injections of neuropeptide Y (NPY; 1–30 μg/kg) were studied in the conscious rabbit. 2. NPY has a brief pressor effect associated with a bradycardia, an increase in left ventricular end diastolic pressure, and a prolonged fall in peak left ventricular dP/dt (LVdP/dt). 3. The haemodynamic changes increase substantially with increasing doses up to 10 μg/kg. Beyond 10 μg/kg there are only slight effects on heart rate or peak LV dP/dt.

Original language	English
Pages (from-to)	263-266
Number of pages	4
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	14
Issue number	3
DOIs	https://doi.org/10.1111/j.1440-1681.1987.tb00387.x
Publication status	Published - Mar 1987
Externally published	Yes

Keywords

arterial pressure
baroreflexes
conscious rabbit
heart rate
left ventricular pressure
myocardial contractility
neuropeptide Y

Access to Document

10.1111/j.1440-1681.1987.tb00387.xLicence: In Copyright

Cite this

@article{d16a78735ec743f4ac7091b1fb4f41e4,

title = "EFFECTS OF NEUROPEPTIDE Y ON LEFT VENTRICULAR FUNCTION IN THE CONSCIOUS RABBIT",

abstract = "1. Changes in arterial pressure, heart rate and left ventricular contractility induced by intravenous injections of neuropeptide Y (NPY; 1–30 μg/kg) were studied in the conscious rabbit. 2. NPY has a brief pressor effect associated with a bradycardia, an increase in left ventricular end diastolic pressure, and a prolonged fall in peak left ventricular dP/dt (LVdP/dt). 3. The haemodynamic changes increase substantially with increasing doses up to 10 μg/kg. Beyond 10 μg/kg there are only slight effects on heart rate or peak LV dP/dt.",

keywords = "arterial pressure, baroreflexes, conscious rabbit, heart rate, left ventricular pressure, myocardial contractility, neuropeptide Y",

author = "Minson, {R. B.} and McRitchie, {R. J.} and Chalmers, {J. P.}",

year = "1987",

month = mar,

doi = "10.1111/j.1440-1681.1987.tb00387.x",

language = "English",

volume = "14",

pages = "263--266",

journal = "Clinical and Experimental Pharmacology and Physiology",

issn = "0305-1870",

publisher = "Blackwell Science Asia",

number = "3",

}

TY - JOUR

T1 - EFFECTS OF NEUROPEPTIDE Y ON LEFT VENTRICULAR FUNCTION IN THE CONSCIOUS RABBIT

AU - Minson, R. B.

AU - McRitchie, R. J.

AU - Chalmers, J. P.

PY - 1987/3

Y1 - 1987/3

N2 - 1. Changes in arterial pressure, heart rate and left ventricular contractility induced by intravenous injections of neuropeptide Y (NPY; 1–30 μg/kg) were studied in the conscious rabbit. 2. NPY has a brief pressor effect associated with a bradycardia, an increase in left ventricular end diastolic pressure, and a prolonged fall in peak left ventricular dP/dt (LVdP/dt). 3. The haemodynamic changes increase substantially with increasing doses up to 10 μg/kg. Beyond 10 μg/kg there are only slight effects on heart rate or peak LV dP/dt.

AB - 1. Changes in arterial pressure, heart rate and left ventricular contractility induced by intravenous injections of neuropeptide Y (NPY; 1–30 μg/kg) were studied in the conscious rabbit. 2. NPY has a brief pressor effect associated with a bradycardia, an increase in left ventricular end diastolic pressure, and a prolonged fall in peak left ventricular dP/dt (LVdP/dt). 3. The haemodynamic changes increase substantially with increasing doses up to 10 μg/kg. Beyond 10 μg/kg there are only slight effects on heart rate or peak LV dP/dt.

KW - arterial pressure

KW - baroreflexes

KW - conscious rabbit

KW - heart rate

KW - left ventricular pressure

KW - myocardial contractility

KW - neuropeptide Y

UR - http://www.scopus.com/inward/record.url?scp=0023475481&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1681.1987.tb00387.x

DO - 10.1111/j.1440-1681.1987.tb00387.x

M3 - Article

C2 - 3665194

AN - SCOPUS:0023475481

SN - 0305-1870

VL - 14

SP - 263

EP - 266

JO - Clinical and Experimental Pharmacology and Physiology

JF - Clinical and Experimental Pharmacology and Physiology

IS - 3

ER -

EFFECTS OF NEUROPEPTIDE Y ON LEFT VENTRICULAR FUNCTION IN THE CONSCIOUS RABBIT

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this