EFFECTS OF NEUROPEPTIDE Y ON LEFT VENTRICULAR FUNCTION IN THE CONSCIOUS RABBIT

R. B. Minson; R. J. McRitchie; J. P. Chalmers

doi:10.1111/j.1440-1681.1987.tb00387.x

EFFECTS OF NEUROPEPTIDE Y ON LEFT VENTRICULAR FUNCTION IN THE CONSCIOUS RABBIT

R. B. Minson, R. J. McRitchie, J. P. Chalmers

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

1. Changes in arterial pressure, heart rate and left ventricular contractility induced by intravenous injections of neuropeptide Y (NPY; 1–30 μg/kg) were studied in the conscious rabbit. 2. NPY has a brief pressor effect associated with a bradycardia, an increase in left ventricular end diastolic pressure, and a prolonged fall in peak left ventricular dP/dt (LVdP/dt). 3. The haemodynamic changes increase substantially with increasing doses up to 10 μg/kg. Beyond 10 μg/kg there are only slight effects on heart rate or peak LV dP/dt.

Original language	English
Pages (from-to)	263-266
Number of pages	4
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	14
Issue number	3
DOIs	https://doi.org/10.1111/j.1440-1681.1987.tb00387.x
Publication status	Published - Mar 1987
Externally published	Yes

Keywords

arterial pressure
baroreflexes
conscious rabbit
heart rate
left ventricular pressure
myocardial contractility
neuropeptide Y

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Cite this

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title = "EFFECTS OF NEUROPEPTIDE Y ON LEFT VENTRICULAR FUNCTION IN THE CONSCIOUS RABBIT",

abstract = "1. Changes in arterial pressure, heart rate and left ventricular contractility induced by intravenous injections of neuropeptide Y (NPY; 1–30 μg/kg) were studied in the conscious rabbit. 2. NPY has a brief pressor effect associated with a bradycardia, an increase in left ventricular end diastolic pressure, and a prolonged fall in peak left ventricular dP/dt (LVdP/dt). 3. The haemodynamic changes increase substantially with increasing doses up to 10 μg/kg. Beyond 10 μg/kg there are only slight effects on heart rate or peak LV dP/dt.",

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AB - 1. Changes in arterial pressure, heart rate and left ventricular contractility induced by intravenous injections of neuropeptide Y (NPY; 1–30 μg/kg) were studied in the conscious rabbit. 2. NPY has a brief pressor effect associated with a bradycardia, an increase in left ventricular end diastolic pressure, and a prolonged fall in peak left ventricular dP/dt (LVdP/dt). 3. The haemodynamic changes increase substantially with increasing doses up to 10 μg/kg. Beyond 10 μg/kg there are only slight effects on heart rate or peak LV dP/dt.

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KW - baroreflexes

KW - conscious rabbit

KW - heart rate

KW - left ventricular pressure

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