Abstract
1. Changes in arterial pressure, heart rate and left ventricular contractility induced by intravenous injections of neuropeptide Y (NPY; 1–30 μg/kg) were studied in the conscious rabbit. 2. NPY has a brief pressor effect associated with a bradycardia, an increase in left ventricular end diastolic pressure, and a prolonged fall in peak left ventricular dP/dt (LVdP/dt). 3. The haemodynamic changes increase substantially with increasing doses up to 10 μg/kg. Beyond 10 μg/kg there are only slight effects on heart rate or peak LV dP/dt.
| Original language | English |
|---|---|
| Pages (from-to) | 263-266 |
| Number of pages | 4 |
| Journal | Clinical and Experimental Pharmacology and Physiology |
| Volume | 14 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 1987 |
| Externally published | Yes |
Keywords
- arterial pressure
- baroreflexes
- conscious rabbit
- heart rate
- left ventricular pressure
- myocardial contractility
- neuropeptide Y
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Cite this
Minson, R. B., McRitchie, R. J., & Chalmers, J. P. (1987). EFFECTS OF NEUROPEPTIDE Y ON LEFT VENTRICULAR FUNCTION IN THE CONSCIOUS RABBIT. Clinical and Experimental Pharmacology and Physiology, 14(3), 263-266. https://doi.org/10.1111/j.1440-1681.1987.tb00387.x