Effects of nonsteroidal anti-inflammatory drugs on postoperative renal function in adults with normal renal function

Anna Lee, M. G. Cooper, J. C. Craig, J. F. Knight, J. P. Keneally

Research output: Contribution to journalReview articlepeer-review

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Nonsteroidal anti‐inflammatory drugs (NSAIDs) can play a major role in the management of acute pain in the peri‐operative period. However, there are conflicting views on whether NSAIDs are associated with adverse renal effects.

The primary objective of this review was to determine the effects of NSAIDs on postoperative renal function in adults with normal preoperative renal function.

Search methods
Electronic searches for relevant randomised and quasi‐randomised controlled trials in Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE were performed. Attempts were also made to identify trials from citation lists of relevant trials, review articles and clinical practice guidelines. Handsearching of conference abstracts published in major anaesthetic journals was also performed. (Search date: 7 February 2003)

Selection criteria
The inclusion criteria were randomised or quasi‐randomised comparisons of individual NSAIDs with either each other or placebo for treatment of postoperative pain, with relevant postoperative renal outcome measures, in adult surgical patients with normal renal function.

Data collection and analysis
The data was extracted independently by two reviewers. The primary outcome measure was creatinine clearance within the first two days after surgery. Secondary outcome measures included serum creatinine, urine volume, urinary sodium level, urinary potassium level, fractional excretion of sodium, fractional excretion of potassium, need for dialysis and need for diuretic or dopamine treatment for renal insufficiency. Weighted mean differences for continuous outcomes and relative risk for dichotomous outcomes were estimated.
Original languageEnglish
Article numberCD002765
JournalCochrane Database of Systematic Reviews
Issue number2
Publication statusPublished - 19 Apr 2004
Externally publishedYes

Bibliographical note

This is not the most recent version. Later version published: 18 April 2007.


  • Adult
  • Anti-inflammatory agents, non-steroidal [*adverse effects]
  • Creatinine [blood]
  • Humans
  • Kidney failure [etiology]
  • Kidney [*drug effects]
  • Pain, postoperative [*drug therapy]
  • Randomized controlled trials as topic


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