TY - JOUR
T1 - Effects of Npas4 deficiency on anxiety, depression-like, cognition and sociability behaviour
AU - Jaehne, Emily
AU - Klaric, Thomas
AU - Koblar, S
AU - Lewis, Martin
AU - Baune, Bernhard
PY - 2015/3/5
Y1 - 2015/3/5
N2 -
The transcription factor neuronal PAS domain-containing protein 4 (Npas4), which regulates the formation of inhibitory synapses on excitatory neurons, has been suggested as a candidate gene for neurological and psychiatric conditions such as bipolar depression, autism spectrum and cognitive disorders. A mouse model of Npas4 deficiency has been developed to investigate any role in these disorders. Behavioural characterisation of Npas4
-/-
, Npas4
+/-
and Npas4
+/+
mice has been conducted using the open field, elevated zero maze (EZM), Y-maze, sociability test and forced swim test (FST) to investigate a range of behaviours. Npas4
-/-
mice spent more time in the open arm of the EZM than other genotypes, suggesting decreased anxiety-like behaviour. Npas4
+/-
mice, however, were more immobile in the FST than other genotypes, suggesting increased depression-like behaviour, and also showed impaired spatial recognition memory in the Y-maze. There were no differences between genotype in social behaviour. These results suggest that differential levels of Npas4 expression in the brain may regulate anxiety, depression and cognition related disorders.
AB -
The transcription factor neuronal PAS domain-containing protein 4 (Npas4), which regulates the formation of inhibitory synapses on excitatory neurons, has been suggested as a candidate gene for neurological and psychiatric conditions such as bipolar depression, autism spectrum and cognitive disorders. A mouse model of Npas4 deficiency has been developed to investigate any role in these disorders. Behavioural characterisation of Npas4
-/-
, Npas4
+/-
and Npas4
+/+
mice has been conducted using the open field, elevated zero maze (EZM), Y-maze, sociability test and forced swim test (FST) to investigate a range of behaviours. Npas4
-/-
mice spent more time in the open arm of the EZM than other genotypes, suggesting decreased anxiety-like behaviour. Npas4
+/-
mice, however, were more immobile in the FST than other genotypes, suggesting increased depression-like behaviour, and also showed impaired spatial recognition memory in the Y-maze. There were no differences between genotype in social behaviour. These results suggest that differential levels of Npas4 expression in the brain may regulate anxiety, depression and cognition related disorders.
KW - Anxiety
KW - Depression
KW - Memory
KW - Neuronal PAS domain-containing protein 4
KW - Sociability
UR - http://www.scopus.com/inward/record.url?scp=84920280312&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2014.12.044
DO - 10.1016/j.bbr.2014.12.044
M3 - Article
VL - 281
SP - 276
EP - 282
JO - BEHAVIOURAL BRAIN RESEARCH
JF - BEHAVIOURAL BRAIN RESEARCH
SN - 0166-4328
ER -