Effects of Omeprazole on Peptic Oesophagitis and Oesophageal Motility and pH

J. Dent; J. Downton; R. Heddle; P. J. Buckle; J. Toouli; A. M. Mackinnon; J. B. Wyman

doi:10.3109/00365528609090939

Effects of Omeprazole on Peptic Oesophagitis and Oesophageal Motility and pH

J. Dent, J. Downton, R. Heddle, P. J. Buckle, J. Toouli, A. M. Mackinnon, J. B. Wyman

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Conventional dose regimens of H₂-receptor blocking drugs have proved relatively ineffective for treatment of peptic oesophagitis. Animal model studies of peptic oesophagitis suggest that more profound suppression of acid secretion than that normally achieved by H₂-receptor blockers could result in marked reduction of the oesophageal mucosa damaging properties of gastric juice. Once daily omeprazole can produce almost total suppression of gastric acid secretion. In this open pilot study we sought to determine whether such an effect is associated with symptomatic and endoscopic benefit in patients with troublesome peptic oesophagitis.

Original language	English
Pages (from-to)	181
Number of pages	1
Journal	Scandinavian Journal of Gastroenterology
Volume	21
Issue number	Suppl. 118
DOIs	https://doi.org/10.3109/00365528609090939
Publication status	Published - 1986
Externally published	Yes

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abstract = "Conventional dose regimens of H2-receptor blocking drugs have proved relatively ineffective for treatment of peptic oesophagitis. Animal model studies of peptic oesophagitis suggest that more profound suppression of acid secretion than that normally achieved by H2-receptor blockers could result in marked reduction of the oesophageal mucosa damaging properties of gastric juice. Once daily omeprazole can produce almost total suppression of gastric acid secretion. In this open pilot study we sought to determine whether such an effect is associated with symptomatic and endoscopic benefit in patients with troublesome peptic oesophagitis.",

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AU - Dent, J.

AU - Downton, J.

AU - Heddle, R.

AU - Buckle, P. J.

AU - Toouli, J.

AU - Mackinnon, A. M.

AU - Wyman, J. B.

PY - 1986

Y1 - 1986

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AB - Conventional dose regimens of H2-receptor blocking drugs have proved relatively ineffective for treatment of peptic oesophagitis. Animal model studies of peptic oesophagitis suggest that more profound suppression of acid secretion than that normally achieved by H2-receptor blockers could result in marked reduction of the oesophageal mucosa damaging properties of gastric juice. Once daily omeprazole can produce almost total suppression of gastric acid secretion. In this open pilot study we sought to determine whether such an effect is associated with symptomatic and endoscopic benefit in patients with troublesome peptic oesophagitis.

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JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

IS - Suppl. 118

ER -

Effects of Omeprazole on Peptic Oesophagitis and Oesophageal Motility and pH

Abstract

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