Effects of perindopril-indapamide on left ventricular diastolic function and mass in patients with type 2 diabetes: The ADVANCE Echocardiography Substudy

Robert Doughty; Gillian Whalley; Greg Gamble; John Baker; John Chalmers; Mark Cooper; Kennedy Cruickshank; Peter Dixon; Peter Dunne; David Eccleston; George Jerums; Richard Luke; Barry McGrath; Christopher Nolan; Anushka Patel; Neil Poulter; Patrick Phillips; Russell Scott; Jasvinder Singh; Robert Smith; Alice Stanton; Michael Suranyi; Simon Thom; Mark Woodward; G Jerums; Helen Walsh; Stephen MacMahon; Eleuterio Ferrannini; Paul Glasziou; Diederick Grobbee; Pavel Hamet; Stephen Harrap; S Heller; Lisheng Liu; Giuseppe Mancia; Michel Marre; Carl Mogensen; Bruce Neal; Chang Yu Pan; A Rodgers; Bryan Williams; Carolyn Jacklin; Karen McNeil; Piyush Srivastava; Todor Arsov; Manuel Correcha; Mary Hines; F Margrie; U Musial; Nikolai Petrovsky; Diego Silva; Luis Socha; Jeffrey Sutherland; K Gordijn; K Grigarius; Christian Meyer; Rinki Singh; Helena Teede; J Wong; A Yeap; Sophia Zoungas; Christine Allman; Josephine Chow; M Curtale; Dominic Leung; Betsy Malkus; Glenda Rayment; Timothy Spicer; M Wong; Sharon Mackintosh; Cathy Miller; P Phillips; Stephen Stranks; Paul Taylor; Scott Baker; Logan Bittinger; R Cotton; Penelope Harvey; Bruce Jackson; L Laqui; V Lawlor; Siaw-Teng Liaw; Christopher Neil; M Park; Erosha Premaratne; Felicity Pyrlis; Gloria Rudge; J Cruickshank; Moulinath Banerjee; John Collins; J Dunkerley; Cheryce Harrison; Kay Hart; Mark Holland; Rajdeep Khattar; Manju Luckson; Sylvia Shaw; Thomas Wood; Robert Elkeles; Jamil Mayet; Andrew Sharp; Andrew Whitehouse; Jean Mackay; J Bunker; W Callister; Cecil Coghlan; Raul Fernandez; Vicki Gordon; Jane Harman; Narvada Jugnee; L Knisley; Anne McKerracher; Simon Mitchell; Sinead Murphy; Alastair Strain; O Trainor; Basel Aloul; Cathal Collier; Eamon Dolan; Christopher Foley; Barbara Gallagher; B Gusau; L Hacke; E Ho; Simon Lyons; Brian Maguire; Tim Morgan; Christopher Thompson; M Twohill; Christopher Florkowski; A Kwon; Roberta McEwan; Patrice McGregor; Margaret Milne; Christopher Strey; Richard Troughton; Gordon Brown; V D'Ath; Jane Kenyon; Robert Leikis; Richard Clarke; Ajith Dissanayake; S Gunatilaka; Julia Leary; Ilene Rosen; M Te Whiu; H Walsh; Stephanie Austin; Robert Clarke; L Howitt; Gina Ward; G Carswell; Peter Hansen; Mary Lane; D Nesdale; Peter Dunn; Raewyn Fisher; Elham Reda; A Johnstone; Lynne McLeod; F Bartley; Alyson Waterman; Juliet Jensen; Douglas Owens; Tracy Clarke; P Cresswell; Agnes Ferguson; Mark Simmonds; Stephan Winter

doi:10.1097/HJH.0b013e3283480fe9

Effects of perindopril-indapamide on left ventricular diastolic function and mass in patients with type 2 diabetes: The ADVANCE Echocardiography Substudy

Robert Doughty, Gillian Whalley, Greg Gamble, John Baker, John Chalmers, Mark Cooper, Kennedy Cruickshank, Peter Dixon, Peter Dunne, David Eccleston, George Jerums, Richard Luke, Barry McGrath, Christopher Nolan, Anushka Patel, Neil Poulter, Patrick Phillips, Russell Scott, Jasvinder Singh, Robert SmithAlice Stanton, Michael Suranyi, Simon Thom, Mark Woodward, G Jerums, Helen Walsh, Stephen MacMahon, Eleuterio Ferrannini, Paul Glasziou, Diederick Grobbee, Pavel Hamet, Stephen Harrap, S Heller, Lisheng Liu, Giuseppe Mancia, Michel Marre, Carl Mogensen, Bruce Neal, Chang Yu Pan, A Rodgers, Bryan Williams, Carolyn Jacklin, Karen McNeil, Piyush Srivastava, Todor Arsov, Manuel Correcha, Mary Hines, F Margrie, U Musial, Nikolai Petrovsky, Diego Silva, Luis Socha, Jeffrey Sutherland, K Gordijn, K Grigarius, Christian Meyer, Rinki Singh, Helena Teede, J Wong, A Yeap, Sophia Zoungas, Christine Allman, Josephine Chow, M Curtale, Dominic Leung, Betsy Malkus, Glenda Rayment, Timothy Spicer, M Wong, Sharon Mackintosh, Cathy Miller, P Phillips, Stephen Stranks, Paul Taylor, Scott Baker, Logan Bittinger, R Cotton, Penelope Harvey, Bruce Jackson, L Laqui, V Lawlor, Siaw-Teng Liaw, Christopher Neil, M Park, Erosha Premaratne, Felicity Pyrlis, Gloria Rudge, J Cruickshank, Moulinath Banerjee, John Collins, J Dunkerley, Cheryce Harrison, Kay Hart, Mark Holland, Rajdeep Khattar, Manju Luckson, Sylvia Shaw, Thomas Wood, Robert Elkeles, Jamil Mayet, Andrew Sharp, Andrew Whitehouse, Jean Mackay, J Bunker, W Callister, Cecil Coghlan, Raul Fernandez, Vicki Gordon, Jane Harman, Narvada Jugnee, L Knisley, Anne McKerracher, Simon Mitchell, Sinead Murphy, Alastair Strain, O Trainor, Basel Aloul, Cathal Collier, Eamon Dolan, Christopher Foley, Barbara Gallagher, B Gusau, L Hacke, E Ho, Simon Lyons, Brian Maguire, Tim Morgan, Christopher Thompson, M Twohill, Christopher Florkowski, A Kwon, Roberta McEwan, Patrice McGregor, Margaret Milne, Christopher Strey, Richard Troughton, Gordon Brown, V D'Ath, Jane Kenyon, Robert Leikis, Richard Clarke, Ajith Dissanayake, S Gunatilaka, Julia Leary, Ilene Rosen, M Te Whiu, H Walsh, Stephanie Austin, Robert Clarke, L Howitt, Gina Ward, G Carswell, Peter Hansen, Mary Lane, D Nesdale, Peter Dunn, Raewyn Fisher, Elham Reda, A Johnstone, Lynne McLeod, F Bartley, Alyson Waterman, Juliet Jensen, Douglas Owens, Tracy Clarke, P Cresswell, Agnes Ferguson, Mark Simmonds, Stephan Winter

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: The Action in Diabetes and Vascular Disease (ADVANCE) Study demonstrated that a fixed combination of perindopril and indapamide reduced the risk of major vascular events and mortality in patients with type 2 diabetes. This Echocardiographic Substudy was designed to determine the effects of this treatment on left ventricular diastolic function and left ventricular mass. Methods: Five hundred and fifty-five patients entering ADVANCE underwent quantitative echocardiography prior to randomization and after 6 months and 4 years of treatment with perindopril-indapamide or placebo. Main end points were left ventricular diastolic function (ratio of mitral E velocity/early medial mitral annular tissue Doppler velocity, E/Em, and left atrial volume index) and left ventricular mass index. Results: Overall, blood pressure was reduced in the perindopril-indapamide group compared with placebo. E/Em and left atrial volume index both increased over the 4 years. There was no effect of perindopril-indapamide on E/Em, although there was a small attenuation of the increase in left atrial volume index with active treatment. Left ventricular mass index was reduced by 2.7 g/m with active treatment (95% confidence interval -5.0 to -0.1, P = 0.04). Conclusion: Compared with placebo, the perindopril-indapamide combination reduced blood pressure and left ventricular mass in patients with diabetes, but did not improve left ventricular diastolic function. Left ventricular diastolic function worsened in both groups over 4 years, despite blood pressure reduction and reduction in left ventricular mass. Improving left ventricular diastolic function remains a challenge in patients with diabetes.

Original language	English
Pages (from-to)	1439-1447
Number of pages	9
Journal	Journal of Hypertension
Volume	29
Issue number	7
DOIs	https://doi.org/10.1097/HJH.0b013e3283480fe9
Publication status	Published - 2011

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10.1097/HJH.0b013e3283480fe9

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Doughty, R., Whalley, G., Gamble, G., Baker, J., Chalmers, J., Cooper, M., Cruickshank, K., Dixon, P., Dunne, P., Eccleston, D., Jerums, G., Luke, R., McGrath, B., Nolan, C., Patel, A., Poulter, N., Phillips, P., Scott, R., Singh, J., ... Winter, S. (2011). Effects of perindopril-indapamide on left ventricular diastolic function and mass in patients with type 2 diabetes: The ADVANCE Echocardiography Substudy. Journal of Hypertension, 29(7), 1439-1447. https://doi.org/10.1097/HJH.0b013e3283480fe9

@article{779095c9c51c4f5f976a817e2b4f0633,

title = "Effects of perindopril-indapamide on left ventricular diastolic function and mass in patients with type 2 diabetes: The ADVANCE Echocardiography Substudy",

abstract = "Background: The Action in Diabetes and Vascular Disease (ADVANCE) Study demonstrated that a fixed combination of perindopril and indapamide reduced the risk of major vascular events and mortality in patients with type 2 diabetes. This Echocardiographic Substudy was designed to determine the effects of this treatment on left ventricular diastolic function and left ventricular mass. Methods: Five hundred and fifty-five patients entering ADVANCE underwent quantitative echocardiography prior to randomization and after 6 months and 4 years of treatment with perindopril-indapamide or placebo. Main end points were left ventricular diastolic function (ratio of mitral E velocity/early medial mitral annular tissue Doppler velocity, E/Em, and left atrial volume index) and left ventricular mass index. Results: Overall, blood pressure was reduced in the perindopril-indapamide group compared with placebo. E/Em and left atrial volume index both increased over the 4 years. There was no effect of perindopril-indapamide on E/Em, although there was a small attenuation of the increase in left atrial volume index with active treatment. Left ventricular mass index was reduced by 2.7 g/m with active treatment (95% confidence interval -5.0 to -0.1, P = 0.04). Conclusion: Compared with placebo, the perindopril-indapamide combination reduced blood pressure and left ventricular mass in patients with diabetes, but did not improve left ventricular diastolic function. Left ventricular diastolic function worsened in both groups over 4 years, despite blood pressure reduction and reduction in left ventricular mass. Improving left ventricular diastolic function remains a challenge in patients with diabetes.",

author = "Robert Doughty and Gillian Whalley and Greg Gamble and John Baker and John Chalmers and Mark Cooper and Kennedy Cruickshank and Peter Dixon and Peter Dunne and David Eccleston and George Jerums and Richard Luke and Barry McGrath and Christopher Nolan and Anushka Patel and Neil Poulter and Patrick Phillips and Russell Scott and Jasvinder Singh and Robert Smith and Alice Stanton and Michael Suranyi and Simon Thom and Mark Woodward and G Jerums and Helen Walsh and Stephen MacMahon and Eleuterio Ferrannini and Paul Glasziou and Diederick Grobbee and Pavel Hamet and Stephen Harrap and S Heller and Lisheng Liu and Giuseppe Mancia and Michel Marre and Carl Mogensen and Bruce Neal and Pan, {Chang Yu} and A Rodgers and Bryan Williams and Carolyn Jacklin and Karen McNeil and Piyush Srivastava and Todor Arsov and Manuel Correcha and Mary Hines and F Margrie and U Musial and Nikolai Petrovsky and Diego Silva and Luis Socha and Jeffrey Sutherland and K Gordijn and K Grigarius and Christian Meyer and Rinki Singh and Helena Teede and J Wong and A Yeap and Sophia Zoungas and Christine Allman and Josephine Chow and M Curtale and Dominic Leung and Betsy Malkus and Glenda Rayment and Timothy Spicer and M Wong and Sharon Mackintosh and Cathy Miller and P Phillips and Stephen Stranks and Paul Taylor and Scott Baker and Logan Bittinger and R Cotton and Penelope Harvey and Bruce Jackson and L Laqui and V Lawlor and Siaw-Teng Liaw and Christopher Neil and M Park and Erosha Premaratne and Felicity Pyrlis and Gloria Rudge and J Cruickshank and Moulinath Banerjee and John Collins and J Dunkerley and Cheryce Harrison and Kay Hart and Mark Holland and Rajdeep Khattar and Manju Luckson and Sylvia Shaw and Thomas Wood and Robert Elkeles and Jamil Mayet and Andrew Sharp and Andrew Whitehouse and Jean Mackay and J Bunker and W Callister and Cecil Coghlan and Raul Fernandez and Vicki Gordon and Jane Harman and Narvada Jugnee and L Knisley and Anne McKerracher and Simon Mitchell and Sinead Murphy and Alastair Strain and O Trainor and Basel Aloul and Cathal Collier and Eamon Dolan and Christopher Foley and Barbara Gallagher and B Gusau and L Hacke and E Ho and Simon Lyons and Brian Maguire and Tim Morgan and Christopher Thompson and M Twohill and Christopher Florkowski and A Kwon and Roberta McEwan and Patrice McGregor and Margaret Milne and Christopher Strey and Richard Troughton and Gordon Brown and V D'Ath and Jane Kenyon and Robert Leikis and Richard Clarke and Ajith Dissanayake and S Gunatilaka and Julia Leary and Ilene Rosen and {Te Whiu}, M and H Walsh and Stephanie Austin and Robert Clarke and L Howitt and Gina Ward and G Carswell and Peter Hansen and Mary Lane and D Nesdale and Peter Dunn and Raewyn Fisher and Elham Reda and A Johnstone and Lynne McLeod and F Bartley and Alyson Waterman and Juliet Jensen and Douglas Owens and Tracy Clarke and P Cresswell and Agnes Ferguson and Mark Simmonds and Stephan Winter",

year = "2011",

doi = "10.1097/HJH.0b013e3283480fe9",

language = "English",

volume = "29",

pages = "1439--1447",

journal = "Journal of Hypertension",

issn = "0263-6352",

publisher = "Wolters Kluwer Health",

number = "7",

}

Doughty, R, Whalley, G, Gamble, G, Baker, J, Chalmers, J, Cooper, M, Cruickshank, K, Dixon, P, Dunne, P, Eccleston, D, Jerums, G, Luke, R, McGrath, B, Nolan, C, Patel, A, Poulter, N, Phillips, P, Scott, R, Singh, J, Smith, R, Stanton, A, Suranyi, M, Thom, S, Woodward, M, Jerums, G, Walsh, H, MacMahon, S, Ferrannini, E, Glasziou, P, Grobbee, D, Hamet, P, Harrap, S, Heller, S, Liu, L, Mancia, G, Marre, M, Mogensen, C, Neal, B, Pan, CY, Rodgers, A, Williams, B, Jacklin, C, McNeil, K, Srivastava, P, Arsov, T, Correcha, M, Hines, M, Margrie, F, Musial, U, Petrovsky, N, Silva, D, Socha, L, Sutherland, J, Gordijn, K, Grigarius, K, Meyer, C, Singh, R, Teede, H, Wong, J, Yeap, A, Zoungas, S, Allman, C, Chow, J, Curtale, M, Leung, D, Malkus, B, Rayment, G, Spicer, T, Wong, M, Mackintosh, S, Miller, C, Phillips, P, Stranks, S, Taylor, P, Baker, S, Bittinger, L, Cotton, R, Harvey, P, Jackson, B, Laqui, L, Lawlor, V, Liaw, S-T, Neil, C, Park, M, Premaratne, E, Pyrlis, F, Rudge, G, Cruickshank, J, Banerjee, M, Collins, J, Dunkerley, J, Harrison, C, Hart, K, Holland, M, Khattar, R, Luckson, M, Shaw, S, Wood, T, Elkeles, R, Mayet, J, Sharp, A, Whitehouse, A, Mackay, J, Bunker, J, Callister, W, Coghlan, C, Fernandez, R, Gordon, V, Harman, J, Jugnee, N, Knisley, L, McKerracher, A, Mitchell, S, Murphy, S, Strain, A, Trainor, O, Aloul, B, Collier, C, Dolan, E, Foley, C, Gallagher, B, Gusau, B, Hacke, L, Ho, E, Lyons, S, Maguire, B, Morgan, T, Thompson, C, Twohill, M, Florkowski, C, Kwon, A, McEwan, R, McGregor, P, Milne, M, Strey, C, Troughton, R, Brown, G, D'Ath, V, Kenyon, J, Leikis, R, Clarke, R, Dissanayake, A, Gunatilaka, S, Leary, J, Rosen, I, Te Whiu, M, Walsh, H, Austin, S, Clarke, R, Howitt, L, Ward, G, Carswell, G, Hansen, P, Lane, M, Nesdale, D, Dunn, P, Fisher, R, Reda, E, Johnstone, A, McLeod, L, Bartley, F, Waterman, A, Jensen, J, Owens, D, Clarke, T, Cresswell, P, Ferguson, A, Simmonds, M & Winter, S 2011, 'Effects of perindopril-indapamide on left ventricular diastolic function and mass in patients with type 2 diabetes: The ADVANCE Echocardiography Substudy', Journal of Hypertension, vol. 29, no. 7, pp. 1439-1447. https://doi.org/10.1097/HJH.0b013e3283480fe9

TY - JOUR

T1 - Effects of perindopril-indapamide on left ventricular diastolic function and mass in patients with type 2 diabetes: The ADVANCE Echocardiography Substudy

AU - Doughty, Robert

AU - Whalley, Gillian

AU - Gamble, Greg

AU - Baker, John

AU - Chalmers, John

AU - Cooper, Mark

AU - Cruickshank, Kennedy

AU - Dixon, Peter

AU - Dunne, Peter

AU - Eccleston, David

AU - Jerums, George

AU - Luke, Richard

AU - McGrath, Barry

AU - Nolan, Christopher

AU - Patel, Anushka

AU - Poulter, Neil

AU - Phillips, Patrick

AU - Scott, Russell

AU - Singh, Jasvinder

AU - Smith, Robert

AU - Stanton, Alice

AU - Suranyi, Michael

AU - Thom, Simon

AU - Woodward, Mark

AU - Jerums, G

AU - Walsh, Helen

AU - MacMahon, Stephen

AU - Ferrannini, Eleuterio

AU - Glasziou, Paul

AU - Grobbee, Diederick

AU - Hamet, Pavel

AU - Harrap, Stephen

AU - Heller, S

AU - Liu, Lisheng

AU - Mancia, Giuseppe

AU - Marre, Michel

AU - Mogensen, Carl

AU - Neal, Bruce

AU - Pan, Chang Yu

AU - Rodgers, A

AU - Williams, Bryan

AU - Jacklin, Carolyn

AU - McNeil, Karen

AU - Srivastava, Piyush

AU - Arsov, Todor

AU - Correcha, Manuel

AU - Hines, Mary

AU - Margrie, F

AU - Musial, U

AU - Petrovsky, Nikolai

AU - Silva, Diego

AU - Socha, Luis

AU - Sutherland, Jeffrey

AU - Gordijn, K

AU - Grigarius, K

AU - Meyer, Christian

AU - Singh, Rinki

AU - Teede, Helena

AU - Wong, J

AU - Yeap, A

AU - Zoungas, Sophia

AU - Allman, Christine

AU - Chow, Josephine

AU - Curtale, M

AU - Leung, Dominic

AU - Malkus, Betsy

AU - Rayment, Glenda

AU - Spicer, Timothy

AU - Wong, M

AU - Mackintosh, Sharon

AU - Miller, Cathy

AU - Phillips, P

AU - Stranks, Stephen

AU - Taylor, Paul

AU - Baker, Scott

AU - Bittinger, Logan

AU - Cotton, R

AU - Harvey, Penelope

AU - Jackson, Bruce

AU - Laqui, L

AU - Lawlor, V

AU - Liaw, Siaw-Teng

AU - Neil, Christopher

AU - Park, M

AU - Premaratne, Erosha

AU - Pyrlis, Felicity

AU - Rudge, Gloria

AU - Cruickshank, J

AU - Banerjee, Moulinath

AU - Collins, John

AU - Dunkerley, J

AU - Harrison, Cheryce

AU - Hart, Kay

AU - Holland, Mark

AU - Khattar, Rajdeep

AU - Luckson, Manju

AU - Shaw, Sylvia

AU - Wood, Thomas

AU - Elkeles, Robert

AU - Mayet, Jamil

AU - Sharp, Andrew

AU - Whitehouse, Andrew

AU - Mackay, Jean

AU - Bunker, J

AU - Callister, W

AU - Coghlan, Cecil

AU - Fernandez, Raul

AU - Gordon, Vicki

AU - Harman, Jane

AU - Jugnee, Narvada

AU - Knisley, L

AU - McKerracher, Anne

AU - Mitchell, Simon

AU - Murphy, Sinead

AU - Strain, Alastair

AU - Trainor, O

AU - Aloul, Basel

AU - Collier, Cathal

AU - Dolan, Eamon

AU - Foley, Christopher

AU - Gallagher, Barbara

AU - Gusau, B

AU - Hacke, L

AU - Ho, E

AU - Lyons, Simon

AU - Maguire, Brian

AU - Morgan, Tim

AU - Thompson, Christopher

AU - Twohill, M

AU - Florkowski, Christopher

AU - Kwon, A

AU - McEwan, Roberta

AU - McGregor, Patrice

AU - Milne, Margaret

AU - Strey, Christopher

AU - Troughton, Richard

AU - Brown, Gordon

AU - D'Ath, V

AU - Kenyon, Jane

AU - Leikis, Robert

AU - Clarke, Richard

AU - Dissanayake, Ajith

AU - Gunatilaka, S

AU - Leary, Julia

AU - Rosen, Ilene

AU - Te Whiu, M

AU - Walsh, H

AU - Austin, Stephanie

AU - Clarke, Robert

AU - Howitt, L

AU - Ward, Gina

AU - Carswell, G

AU - Hansen, Peter

AU - Lane, Mary

AU - Nesdale, D

AU - Dunn, Peter

AU - Fisher, Raewyn

AU - Reda, Elham

AU - Johnstone, A

AU - McLeod, Lynne

AU - Bartley, F

AU - Waterman, Alyson

AU - Jensen, Juliet

AU - Owens, Douglas

AU - Clarke, Tracy

AU - Cresswell, P

AU - Ferguson, Agnes

AU - Simmonds, Mark

AU - Winter, Stephan

PY - 2011

Y1 - 2011

N2 - Background: The Action in Diabetes and Vascular Disease (ADVANCE) Study demonstrated that a fixed combination of perindopril and indapamide reduced the risk of major vascular events and mortality in patients with type 2 diabetes. This Echocardiographic Substudy was designed to determine the effects of this treatment on left ventricular diastolic function and left ventricular mass. Methods: Five hundred and fifty-five patients entering ADVANCE underwent quantitative echocardiography prior to randomization and after 6 months and 4 years of treatment with perindopril-indapamide or placebo. Main end points were left ventricular diastolic function (ratio of mitral E velocity/early medial mitral annular tissue Doppler velocity, E/Em, and left atrial volume index) and left ventricular mass index. Results: Overall, blood pressure was reduced in the perindopril-indapamide group compared with placebo. E/Em and left atrial volume index both increased over the 4 years. There was no effect of perindopril-indapamide on E/Em, although there was a small attenuation of the increase in left atrial volume index with active treatment. Left ventricular mass index was reduced by 2.7 g/m with active treatment (95% confidence interval -5.0 to -0.1, P = 0.04). Conclusion: Compared with placebo, the perindopril-indapamide combination reduced blood pressure and left ventricular mass in patients with diabetes, but did not improve left ventricular diastolic function. Left ventricular diastolic function worsened in both groups over 4 years, despite blood pressure reduction and reduction in left ventricular mass. Improving left ventricular diastolic function remains a challenge in patients with diabetes.

AB - Background: The Action in Diabetes and Vascular Disease (ADVANCE) Study demonstrated that a fixed combination of perindopril and indapamide reduced the risk of major vascular events and mortality in patients with type 2 diabetes. This Echocardiographic Substudy was designed to determine the effects of this treatment on left ventricular diastolic function and left ventricular mass. Methods: Five hundred and fifty-five patients entering ADVANCE underwent quantitative echocardiography prior to randomization and after 6 months and 4 years of treatment with perindopril-indapamide or placebo. Main end points were left ventricular diastolic function (ratio of mitral E velocity/early medial mitral annular tissue Doppler velocity, E/Em, and left atrial volume index) and left ventricular mass index. Results: Overall, blood pressure was reduced in the perindopril-indapamide group compared with placebo. E/Em and left atrial volume index both increased over the 4 years. There was no effect of perindopril-indapamide on E/Em, although there was a small attenuation of the increase in left atrial volume index with active treatment. Left ventricular mass index was reduced by 2.7 g/m with active treatment (95% confidence interval -5.0 to -0.1, P = 0.04). Conclusion: Compared with placebo, the perindopril-indapamide combination reduced blood pressure and left ventricular mass in patients with diabetes, but did not improve left ventricular diastolic function. Left ventricular diastolic function worsened in both groups over 4 years, despite blood pressure reduction and reduction in left ventricular mass. Improving left ventricular diastolic function remains a challenge in patients with diabetes.

U2 - 10.1097/HJH.0b013e3283480fe9

DO - 10.1097/HJH.0b013e3283480fe9

M3 - Article

SN - 0263-6352

VL - 29

SP - 1439

EP - 1447

JO - Journal of Hypertension

JF - Journal of Hypertension

IS - 7

ER -

Effects of perindopril-indapamide on left ventricular diastolic function and mass in patients with type 2 diabetes: The ADVANCE Echocardiography Substudy

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