TY - JOUR
T1 - Effects of the Trier Social Stress Test on the distributions of IL-6 and MAP levels
AU - Rodríguez-Medina, David A.
AU - Leija-Alva, Gerardo
AU - Domínguez-Trejo, Benjamín
AU - Hernández-Pozo, María del Rocío
AU - Cruz-Albarrán, Irving A.
AU - Morales-Hernández, Luis A.
AU - Marmolejo-Ramos, Fernando
PY - 2019/4
Y1 - 2019/4
N2 - Trier Social Stress Test (TSST) is an experimental psychological test that induces changes in autonomic, endocrinological and immunological activity. Two measures used to evaluate the inflammatory activity induced by this test are the interleukin 6 (IL-6), a cytokine sensitive to changes in sympathetic nervous activity, and the mean arterial pressure (MAP), a measure sensitive to changes in autonomic activity. This study had two goals: first, the study examined whether TSST increases IL-6 and MAP levels; second, pre- and post-TSST IL-6 levels were compared for participants whose IL-6 levels increased or decreased due to the TSST. Saliva samples of IL-6 and MAP were taken from 42 participants clinically healthy, without psychiatric history, and data were analysed via quantile comparisons. The results showed that TSST did not lead to an increase in sympathetic activity as indexed by IL-6. Instead, TSST led to increases in MAP. Also, there were significant differences between the IL-6 distributions of people whose IL-6 levels changed from low to high (63%) and from high to low (37%) before and after the TSST. These findings suggest that the TSST will not have the same effect on all participants; that is, individual differences can be assessed using a biomarker to identify people with specialized psychological care needs.
AB - Trier Social Stress Test (TSST) is an experimental psychological test that induces changes in autonomic, endocrinological and immunological activity. Two measures used to evaluate the inflammatory activity induced by this test are the interleukin 6 (IL-6), a cytokine sensitive to changes in sympathetic nervous activity, and the mean arterial pressure (MAP), a measure sensitive to changes in autonomic activity. This study had two goals: first, the study examined whether TSST increases IL-6 and MAP levels; second, pre- and post-TSST IL-6 levels were compared for participants whose IL-6 levels increased or decreased due to the TSST. Saliva samples of IL-6 and MAP were taken from 42 participants clinically healthy, without psychiatric history, and data were analysed via quantile comparisons. The results showed that TSST did not lead to an increase in sympathetic activity as indexed by IL-6. Instead, TSST led to increases in MAP. Also, there were significant differences between the IL-6 distributions of people whose IL-6 levels changed from low to high (63%) and from high to low (37%) before and after the TSST. These findings suggest that the TSST will not have the same effect on all participants; that is, individual differences can be assessed using a biomarker to identify people with specialized psychological care needs.
KW - Clinical psychology
KW - Neuroscience
KW - Physiology
KW - Psychology
UR - http://www.scopus.com/inward/record.url?scp=85064897110&partnerID=8YFLogxK
U2 - 10.1016/j.heliyon.2019.e01580
DO - 10.1016/j.heliyon.2019.e01580
M3 - Article
AN - SCOPUS:85064897110
SN - 2405-8440
VL - 5
JO - Heliyon
JF - Heliyon
IS - 4
M1 - e01580
ER -