TY - JOUR
T1 - Effects of tricyclic antidepressants on drug metabolism
AU - Pond, Susan M.
AU - Graham, Garry G.
AU - Birkett, Donald J.
AU - Wade, Denis N.
PY - 1975/8
Y1 - 1975/8
N2 - The effects of chronic treatment with amitriptyline and nortriptyline on the elimination from plasma of warfarin, dicumarol, phenytoin, and tolbutamide were examined in man. No alteration of plasma half-life of warfarin, phenytoin, or tolbutamide was observed following dosage with the tricyclic antidepressants used. There was no consistent effect on the metabolism of dicumarol following treatment with amitriptyline or nortriptyline although the bioavailability of dicumarol appeared to be increased. In some subjects, this increased bioavailability was associated with significant prolongation of the plasma half-life of dicumarol due to its dose-dependent kinetics.
AB - The effects of chronic treatment with amitriptyline and nortriptyline on the elimination from plasma of warfarin, dicumarol, phenytoin, and tolbutamide were examined in man. No alteration of plasma half-life of warfarin, phenytoin, or tolbutamide was observed following dosage with the tricyclic antidepressants used. There was no consistent effect on the metabolism of dicumarol following treatment with amitriptyline or nortriptyline although the bioavailability of dicumarol appeared to be increased. In some subjects, this increased bioavailability was associated with significant prolongation of the plasma half-life of dicumarol due to its dose-dependent kinetics.
UR - http://www.scopus.com/inward/record.url?scp=0016824348&partnerID=8YFLogxK
U2 - 10.1002/cpt1975182191
DO - 10.1002/cpt1975182191
M3 - Article
C2 - 50160
AN - SCOPUS:0016824348
SN - 0009-9236
VL - 18
SP - 191
EP - 199
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
IS - 2
ER -