Effects of tricyclic antidepressants on drug metabolism

Susan M. Pond, Garry G. Graham, Donald J. Birkett, Denis N. Wade

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


The effects of chronic treatment with amitriptyline and nortriptyline on the elimination from plasma of warfarin, dicumarol, phenytoin, and tolbutamide were examined in man. No alteration of plasma half-life of warfarin, phenytoin, or tolbutamide was observed following dosage with the tricyclic antidepressants used. There was no consistent effect on the metabolism of dicumarol following treatment with amitriptyline or nortriptyline although the bioavailability of dicumarol appeared to be increased. In some subjects, this increased bioavailability was associated with significant prolongation of the plasma half-life of dicumarol due to its dose-dependent kinetics.

Original languageEnglish
Pages (from-to)191-199
Number of pages9
JournalClinical Pharmacology and Therapeutics
Issue number2
Publication statusPublished - Aug 1975
Externally publishedYes


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