Abstract
Although statins are effective in treating high cholesterol, adverse effects do occur with their use. Efficacy and tolerability vary among statins in different ethnic groups. Indigenous Australians have a high risk for cardiovascular and kidney diseases. Prescribing statins to Indigenous Australians with multi-morbidity requires different strategies to increase efficacy and reduce their toxicity. Previous studies have reported that Indigenous Australians are more susceptible to severe statin-induced myopathies. However, there is a lack of evidence in the underlying genetic factors in this population. This review aims to identify: inter-ethnic differences in the efficacy and safety of statins; major contributing factors accounting for any identified differences; and provide an overview of statin-induced adverse effects in Indigenous Australians.
Original language | English |
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Pages (from-to) | 553-571 |
Number of pages | 19 |
Journal | Pharmacogenomics |
Volume | 22 |
Issue number | 9 |
DOIs | |
Publication status | Published - Jun 2021 |
Externally published | Yes |
Keywords
- ethnic groups
- Indigenous
- pharmacogenetics
- safety
- statin