Efficacy and safety of statins in ethnic differences: a lesson for application in Indigenous Australian patient care

Lemlem G. Gebremichael, Vijayaprakash Suppiah, Michael D. Wiese, Lorraine Mackenzie, Craig Phillips, Desmond B. Williams, Michael S. Roberts

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Although statins are effective in treating high cholesterol, adverse effects do occur with their use. Efficacy and tolerability vary among statins in different ethnic groups. Indigenous Australians have a high risk for cardiovascular and kidney diseases. Prescribing statins to Indigenous Australians with multi-morbidity requires different strategies to increase efficacy and reduce their toxicity. Previous studies have reported that Indigenous Australians are more susceptible to severe statin-induced myopathies. However, there is a lack of evidence in the underlying genetic factors in this population. This review aims to identify: inter-ethnic differences in the efficacy and safety of statins; major contributing factors accounting for any identified differences; and provide an overview of statin-induced adverse effects in Indigenous Australians.

Original languageEnglish
Pages (from-to)553-571
Number of pages19
JournalPharmacogenomics
Volume22
Issue number9
DOIs
Publication statusPublished - Jun 2021
Externally publishedYes

Keywords

  • ethnic groups
  • Indigenous
  • pharmacogenetics
  • safety
  • statin

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