Efficacy of an adjuvanted Middle East Respiratory Syndrome Coronavirus spike protein vaccine in dromedary camels and alpacas

Danielle R. Adney, Lingshu Wang, Neeltje Van Doremalen, Wei Shi, Yi Zhang, Wing-Pui Kong, Megan R. Miller, Trenton Bushmaker, Dana Scott, Emmie de Wit, Kayvon Modjarrad, Nikolai Petrovsky, Barney S. Graham, Richard A. Bowen, Vincent J. Munster

Research output: Contribution to journalArticle

26 Citations (Scopus)
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Abstract

MERS-CoV is present in dromedary camels throughout the Middle East and Africa. Dromedary camels are the primary zoonotic reservoir for human infections. Interruption of the zoonotic transmission chain from camels to humans, therefore, may be an effective strategy to control the ongoing MERS-CoV outbreak. Here we show that vaccination with an adjuvanted MERS-CoV Spike protein subunit vaccine confers complete protection from MERS-CoV disease in alpaca and results in reduced and delayed viral shedding in the upper airways of dromedary camels. Protection in alpaca correlates with high serum neutralizing antibody titers. Lower titers of serum neutralizing antibodies correlate with delayed and significantly reduced shedding in the nasal turbinates of dromedary camels. Together, these data indicate that induction of robust neutralizing humoral immune responses by vaccination of naïve animals reduces shedding that potentially could diminish the risk of zoonotic transmission.

Original languageEnglish
Article number212
Number of pages13
JournalViruses
Volume11
Issue number3
DOIs
Publication statusPublished - 1 Mar 2019

Bibliographical note

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Keywords

  • Camels
  • MERS-CoV
  • One Health
  • Vaccines

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