Efficacy of two doses of external counterpulsation (ECP) on glycemic control in people with type 2 diabetes mellitus: A randomized SHAM-controlled trial

Jeff S. Coombes, Katrin A. Dias, Ravin Lal, Robert G. Fassett, Matthew P. Wallen, Joyce S. Ramos, Suzanna Russell, Natalie K. Vear, Trishan Gajanand, Tom G. Bailey, Daniel J. Green, Brooke K. Coombes, Llion A. Roberts

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Aims: To determine the efficacy of two doses of external counterpulsation (ECP) on glycemic control in people with type 2 diabetes mellitus (T2D), and any persistent benefits 7 weeks following treatment. 

Methods: 50 participants with T2D were randomly assigned to either 1) 20x45-minute ECP sessions over 7 weeks (ECP45), 2) 20x30-minute ECP sessions over 7 weeks (ECP30) or 3) SHAM control. Outcomes were assessed at baseline, after 7 weeks of the intervention and 7 weeks after the interventions finished. Efficacy was determined from changes in HbA1c

Results: After 7 weeks, there were significant between-group differences, with ECP45 lowering HbA1c compared to SHAM (mean [95% CI] −0.7 [-0.1 to −1.3] %; −7 [-1 to −15] mmol/mol). Within group changes were; ECP45 (mean ± SD −0.8 ± 0.8%; −8 ± 8 mmol/mol), ECP30 (-0.2 ± 0.5%; −2 ± 6 mmol/mol) and SHAM (-0.1 ± 0.9%; −1 ± 10 mmol/mol). HbA1c in the ECP45 group remained lower 7 weeks after completing the intervention; ECP45 (7.0 ± 1.1%; 53 ± 26 mmol/mol), ECP30 (7.7 ± 1.4%; 60 ± 16 mmol/mol) and SHAM (7.7 ± 1.0%; 60 ± 10 mmol/mol). 

Conclusions: In people with T2D, ECP45 for 7 weeks improved glycemic control when compared to ECP30 and a SHAM control group.

Original languageEnglish
Article number110701
Number of pages9
JournalDiabetes Research and Clinical Practice
Volume200
Early online date10 May 2023
DOIs
Publication statusPublished - Jun 2023
Externally publishedYes

Keywords

  • Basal disposition index
  • Beta cell function
  • HbA
  • Insulin resistance Insulin resistance
  • Insulin sensitivity

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