Efficacy of two doses of external counterpulsation (ECP) on glycemic control in people with type 2 diabetes mellitus: A randomized SHAM-controlled trial

Jeff S. Coombes; Katrin A. Dias; Ravin Lal; Robert G. Fassett; Matthew P. Wallen; Joyce S. Ramos; Suzanna Russell; Natalie K. Vear; Trishan Gajanand; Tom G. Bailey; Daniel J. Green; Brooke K. Coombes; Llion A. Roberts

doi:10.1016/j.diabres.2023.110701

Efficacy of two doses of external counterpulsation (ECP) on glycemic control in people with type 2 diabetes mellitus: A randomized SHAM-controlled trial

Jeff S. Coombes
, Katrin A. Dias
, Ravin Lal
, Robert G. Fassett
, Matthew P. Wallen
, Joyce S. Ramos
, Suzanna Russell
, Natalie K. Vear
, Trishan Gajanand
, Tom G. Bailey
, Daniel J. Green
, Brooke K. Coombes
, Llion A. Roberts

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Aims: To determine the efficacy of two doses of external counterpulsation (ECP) on glycemic control in people with type 2 diabetes mellitus (T2D), and any persistent benefits 7 weeks following treatment.

Methods: 50 participants with T2D were randomly assigned to either 1) 20x45-minute ECP sessions over 7 weeks (ECP₄₅), 2) 20x30-minute ECP sessions over 7 weeks (ECP₃₀) or 3) SHAM control. Outcomes were assessed at baseline, after 7 weeks of the intervention and 7 weeks after the interventions finished. Efficacy was determined from changes in HbA_1c.

Results: After 7 weeks, there were significant between-group differences, with ECP₄₅ lowering HbA_1c compared to SHAM (mean [95% CI] −0.7 [-0.1 to −1.3] %; −7 [-1 to −15] mmol/mol). Within group changes were; ECP₄₅ (mean ± SD −0.8 ± 0.8%; −8 ± 8 mmol/mol), ECP₃₀ (-0.2 ± 0.5%; −2 ± 6 mmol/mol) and SHAM (-0.1 ± 0.9%; −1 ± 10 mmol/mol). HbA_1c in the ECP₄₅ group remained lower 7 weeks after completing the intervention; ECP₄₅ (7.0 ± 1.1%; 53 ± 26 mmol/mol), ECP₃₀ (7.7 ± 1.4%; 60 ± 16 mmol/mol) and SHAM (7.7 ± 1.0%; 60 ± 10 mmol/mol).

Conclusions: In people with T2D, ECP₄₅ for 7 weeks improved glycemic control when compared to ECP₃₀ and a SHAM control group.

Original language	English
Article number	110701
Number of pages	9
Journal	Diabetes Research and Clinical Practice
Volume	200
Early online date	10 May 2023
DOIs	https://doi.org/10.1016/j.diabres.2023.110701
Publication status	Published - Jun 2023
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Basal disposition index
Beta cell function
HbA
Insulin resistance Insulin resistance
Insulin sensitivity

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10.1016/j.diabres.2023.110701Licence: In Copyright

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Coombes, J. S., Dias, K. A., Lal, R., Fassett, R. G., Wallen, M. P., Ramos, J. S., Russell, S., Vear, N. K., Gajanand, T., Bailey, T. G., Green, D. J., Coombes, B. K., & Roberts, L. A. (2023). Efficacy of two doses of external counterpulsation (ECP) on glycemic control in people with type 2 diabetes mellitus: A randomized SHAM-controlled trial. Diabetes Research and Clinical Practice, 200, Article 110701. https://doi.org/10.1016/j.diabres.2023.110701

@article{d87b5056c8d042a28bcebb2ba8d57ffd,

title = "Efficacy of two doses of external counterpulsation (ECP) on glycemic control in people with type 2 diabetes mellitus: A randomized SHAM-controlled trial",

abstract = "Aims: To determine the efficacy of two doses of external counterpulsation (ECP) on glycemic control in people with type 2 diabetes mellitus (T2D), and any persistent benefits 7 weeks following treatment. Methods: 50 participants with T2D were randomly assigned to either 1) 20x45-minute ECP sessions over 7 weeks (ECP45), 2) 20x30-minute ECP sessions over 7 weeks (ECP30) or 3) SHAM control. Outcomes were assessed at baseline, after 7 weeks of the intervention and 7 weeks after the interventions finished. Efficacy was determined from changes in HbA1c. Results: After 7 weeks, there were significant between-group differences, with ECP45 lowering HbA1c compared to SHAM (mean [95\% CI] −0.7 [-0.1 to −1.3] \%; −7 [-1 to −15] mmol/mol). Within group changes were; ECP45 (mean ± SD −0.8 ± 0.8\%; −8 ± 8 mmol/mol), ECP30 (-0.2 ± 0.5\%; −2 ± 6 mmol/mol) and SHAM (-0.1 ± 0.9\%; −1 ± 10 mmol/mol). HbA1c in the ECP45 group remained lower 7 weeks after completing the intervention; ECP45 (7.0 ± 1.1\%; 53 ± 26 mmol/mol), ECP30 (7.7 ± 1.4\%; 60 ± 16 mmol/mol) and SHAM (7.7 ± 1.0\%; 60 ± 10 mmol/mol). Conclusions: In people with T2D, ECP45 for 7 weeks improved glycemic control when compared to ECP30 and a SHAM control group.",

keywords = "Basal disposition index, Beta cell function, HbA, Insulin resistance Insulin resistance, Insulin sensitivity",

author = "Coombes, \{Jeff S.\} and Dias, \{Katrin A.\} and Ravin Lal and Fassett, \{Robert G.\} and Wallen, \{Matthew P.\} and Ramos, \{Joyce S.\} and Suzanna Russell and Vear, \{Natalie K.\} and Trishan Gajanand and Bailey, \{Tom G.\} and Green, \{Daniel J.\} and Coombes, \{Brooke K.\} and Roberts, \{Llion A.\}",

year = "2023",

month = jun,

doi = "10.1016/j.diabres.2023.110701",

language = "English",

volume = "200",

journal = "Diabetes Research and Clinical Practice",

issn = "0168-8227",

publisher = "Elsevier Ireland Ltd",

}

Coombes, JS, Dias, KA, Lal, R, Fassett, RG, Wallen, MP , Ramos, JS, Russell, S, Vear, NK, Gajanand, T, Bailey, TG, Green, DJ, Coombes, BK & Roberts, LA 2023, 'Efficacy of two doses of external counterpulsation (ECP) on glycemic control in people with type 2 diabetes mellitus: A randomized SHAM-controlled trial', Diabetes Research and Clinical Practice, vol. 200, 110701. https://doi.org/10.1016/j.diabres.2023.110701

TY - JOUR

T1 - Efficacy of two doses of external counterpulsation (ECP) on glycemic control in people with type 2 diabetes mellitus

T2 - A randomized SHAM-controlled trial

AU - Coombes, Jeff S.

AU - Dias, Katrin A.

AU - Lal, Ravin

AU - Fassett, Robert G.

AU - Wallen, Matthew P.

AU - Ramos, Joyce S.

AU - Russell, Suzanna

AU - Vear, Natalie K.

AU - Gajanand, Trishan

AU - Bailey, Tom G.

AU - Green, Daniel J.

AU - Coombes, Brooke K.

AU - Roberts, Llion A.

PY - 2023/6

Y1 - 2023/6

N2 - Aims: To determine the efficacy of two doses of external counterpulsation (ECP) on glycemic control in people with type 2 diabetes mellitus (T2D), and any persistent benefits 7 weeks following treatment. Methods: 50 participants with T2D were randomly assigned to either 1) 20x45-minute ECP sessions over 7 weeks (ECP45), 2) 20x30-minute ECP sessions over 7 weeks (ECP30) or 3) SHAM control. Outcomes were assessed at baseline, after 7 weeks of the intervention and 7 weeks after the interventions finished. Efficacy was determined from changes in HbA1c. Results: After 7 weeks, there were significant between-group differences, with ECP45 lowering HbA1c compared to SHAM (mean [95% CI] −0.7 [-0.1 to −1.3] %; −7 [-1 to −15] mmol/mol). Within group changes were; ECP45 (mean ± SD −0.8 ± 0.8%; −8 ± 8 mmol/mol), ECP30 (-0.2 ± 0.5%; −2 ± 6 mmol/mol) and SHAM (-0.1 ± 0.9%; −1 ± 10 mmol/mol). HbA1c in the ECP45 group remained lower 7 weeks after completing the intervention; ECP45 (7.0 ± 1.1%; 53 ± 26 mmol/mol), ECP30 (7.7 ± 1.4%; 60 ± 16 mmol/mol) and SHAM (7.7 ± 1.0%; 60 ± 10 mmol/mol). Conclusions: In people with T2D, ECP45 for 7 weeks improved glycemic control when compared to ECP30 and a SHAM control group.

AB - Aims: To determine the efficacy of two doses of external counterpulsation (ECP) on glycemic control in people with type 2 diabetes mellitus (T2D), and any persistent benefits 7 weeks following treatment. Methods: 50 participants with T2D were randomly assigned to either 1) 20x45-minute ECP sessions over 7 weeks (ECP45), 2) 20x30-minute ECP sessions over 7 weeks (ECP30) or 3) SHAM control. Outcomes were assessed at baseline, after 7 weeks of the intervention and 7 weeks after the interventions finished. Efficacy was determined from changes in HbA1c. Results: After 7 weeks, there were significant between-group differences, with ECP45 lowering HbA1c compared to SHAM (mean [95% CI] −0.7 [-0.1 to −1.3] %; −7 [-1 to −15] mmol/mol). Within group changes were; ECP45 (mean ± SD −0.8 ± 0.8%; −8 ± 8 mmol/mol), ECP30 (-0.2 ± 0.5%; −2 ± 6 mmol/mol) and SHAM (-0.1 ± 0.9%; −1 ± 10 mmol/mol). HbA1c in the ECP45 group remained lower 7 weeks after completing the intervention; ECP45 (7.0 ± 1.1%; 53 ± 26 mmol/mol), ECP30 (7.7 ± 1.4%; 60 ± 16 mmol/mol) and SHAM (7.7 ± 1.0%; 60 ± 10 mmol/mol). Conclusions: In people with T2D, ECP45 for 7 weeks improved glycemic control when compared to ECP30 and a SHAM control group.

KW - Basal disposition index

KW - Beta cell function

KW - HbA

KW - Insulin resistance Insulin resistance

KW - Insulin sensitivity

UR - https://www.scopus.com/pages/publications/85159602549

U2 - 10.1016/j.diabres.2023.110701

DO - 10.1016/j.diabres.2023.110701

M3 - Article

C2 - 37172647

AN - SCOPUS:85159602549

SN - 0168-8227

VL - 200

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

M1 - 110701

ER -

Efficacy of two doses of external counterpulsation (ECP) on glycemic control in people with type 2 diabetes mellitus: A randomized SHAM-controlled trial

Abstract

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Keywords

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