Efficient access to Unsymmetrically 3-Substituted-1,10-Phenanthrolines via Microwave Assisted Friedländer Condensation with Aldehydes

Genevieve Dennison, Jonathan White, Martin Johnston

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    An efficient method with high conversion percentages (70 – 100 %) for the exclusive synthesis of unsymmetrical 3-functionalised-1,10-phenanthrolines via microwave assisted Friedländer condensation is presented. The method was applied to alkyl and aryl aldehydes and aldehydes containing terminal p-methoxybenzyl (PMB) protected hydroxyl moieties. Deprotection of the terminal alcohol yields 3-alkyl hydroxy-1,10-phenanthrolines containing flexible alkyl linkers which have previously not been achieved. These functionalised compounds constitute key intermediates for the synthesis of flexible, unhindered 1,10-phenanthroline based systems into the future.

    Original languageEnglish
    Pages (from-to)6434-6437
    Number of pages4
    JournalChemistrySelect
    Volume1
    Issue number20
    DOIs
    Publication statusPublished - 2016

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