Sodium concentrations in the human heart increase during ischemia due to failure of the Na-K pump, which results in increases in intracellular Sodium (23Na). This has been demonstrated extensively in animal systems, and has been demonstrated to a lesser extent in humans. Here we describe some technical developments that further advance this field. 23Na exists as a 3/2-spin nucleus its quadrapolar moment results in it having bi-exponential relaxation under typical biological conditions. The relative concentration of these two relaxation components, and T2’s of each of these components may indicate the environment of the nucleus. The sum of these two components yields the total sodium concentration.
|Number of pages||1|
|Publication status||Published - 2006|
|Event||ISMRM 14th Scientific Meeting & Exhibition - Seattle, United States|
Duration: 6 May 2006 → 12 May 2006
Conference number: 14th
|Conference||ISMRM 14th Scientific Meeting & Exhibition|
|Period||6/05/06 → 12/05/06|