The aldol condensation of an enolisable ketone and a benzaldehyde followed by Michael addition of the enone with a second enolisable ketone under solvent free conditions leads to the quantitative formation of a diketone, which can be readily converted to a pyridine (typically >80% overall yield) via a double condensation in the presence of ammonium acetate in acetic acid, allowing access to a diverse range of oligopyridyls including bipyridyls and terpyridyls.
|Number of pages||7|
|Journal||Journal of the Chemical Society. Perkin Transactions 1|
|Publication status||Published - 1 Dec 2001|