Electron immunocytochemical localization of enkephalin-like material in catecholamine-containing cells of the carotid body, the adrenal medulla, and in pheochromocytomas of man and other mammals

I. M. Varndell, F. J. Tapia, J. de Mey, R. A. Rush, S. R. Bloom, J. M. Polak

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    91 Citations (Scopus)

    Abstract

    Enkephalin-like immunoreactivity has been localized to electron-dense secretory granules of cat and piglet carotid bodies and adrenal medullae, horse adrenal medulla, and also to human adrenal medulla and pheochromocytomas using a gold-labeled antibody technique performed at the electron microscopic level. The same granules were also demonstrated to exhibit dopamine-β-hydroxylase-like immunoreactivity, which suggests a granular colocalization of amines and peptides in catecholamine-storing cells.

    Original languageEnglish
    Pages (from-to)682-690
    Number of pages9
    JournalJournal of Histochemistry and Cytochemistry
    Volume30
    Issue number7
    DOIs
    Publication statusPublished - 1982

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