Elevation of ceramide and activation of secretory acid sphingomyelinase in patients with acute coronary syndromes

Wei Pan, Jing Jia Yu, Rui Zheng Shi, Lei Yan, Tian Lun Yang, Yuan Jian Li, Zhuohua Zhang, Guo Long Yu, Yong Ping Bai, Edward Schuchman, Xing Xuan He, Guo Gang Zhang

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    26 Citations (Scopus)

    Abstract

    BACKGROUND: Although there are several reported evidences for a pathogenic role of sphingolipid signaling in atherosclerosis, peripheral blood levels of ceramide and secretory acid sphingomyelinase (S-SMase) activity in patients with acute coronary syndromes (ACS) have not been evaluated. METHODS AND RESULTS: A total of 304 CAD patients and 52 healthy individuals were divided into four groups: control group (n=52), stable angina pectoris (SAP) group (n=98), unstable angina pectoris (UAP) group (n=92), and acute myocardial infarction (AMI) group (n=114). Plasma levels of sphingomyelin (SPM) were elevated in patients with UAP and AMI compared with those in the control and SAP participants. Plasma ceramide levels and S-SMase activity in patients with ACS (including UAP and AMI) on day 0 were significantly higher than those in the control and SAP participants. Elevation in plasma ceramide levels in patients with UAP and AMI was sustained until a day after percutaneous coronary intervention or day 7, respectively. Moreover, in patients with UAP, S-SMase activity elevation on day 0 was followed by a gradual decrease toward the SAP range up to a day after percutaneous coronary intervention. In patients with AMI, elevation in S-SMase activity showed a peak on day 3. CONCLUSION: Serial changes in plasma ceramide and S-SMase activity were documented in patients with ACS. These findings provide an insight into the molecular mechanism of plaque destabilization.

    Original languageEnglish
    Pages (from-to)230-235
    Number of pages6
    JournalCORONARY ARTERY DISEASE
    Volume25
    Issue number3
    DOIs
    Publication statusPublished - May 2014

    Keywords

    • acute coronary syndromes
    • ceramide
    • matrix metalloproteinase
    • secretory acid sphingomyelinase
    • sphingomyelin
    • sphingomyelinase
    • tumor necrosis factor

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