Eliminating the mater clock gene in the murine retina produces myopia

Duk Lee, Ranjay Chakraborty, P. Michael Iuvone, Richard A. Stone, Machelle T. Pardue

Research output: Contribution to conferenceAbstract

Abstract

BMAL1 is a transcription factor that is essential to the operation of the circadian clock mechanism in all tissues of the body, including the retina. Previous studies with chicks have linked intrinsic retinal circadian rhythms to experimental myopia (Stone et al., 2013). In this study, Cre-mediated, retinal specific BMAL1 knockout (KO) mice were examined to determine whether the BMAL1 gene and, by inference, circadian rhythms have a role in normal refractive development of the eye.
Original languageEnglish
Number of pages2
Publication statusPublished - Sep 2016
Externally publishedYes
EventThe Association for Research in Vision and Ophthalmology annual meeting 2012 - Fort Lauderdale Convention Center, Fort Lauderdale, United States
Duration: 6 May 201210 May 2012
Conference number: 14

Conference

ConferenceThe Association for Research in Vision and Ophthalmology annual meeting 2012
Abbreviated titleARVO 2012
CountryUnited States
CityFort Lauderdale
Period6/05/1210/05/12

Bibliographical note

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. CC BY-NC-ND

Keywords

  • myopia
  • BMAL1 gene
  • mice
  • retina

Fingerprint Dive into the research topics of 'Eliminating the mater clock gene in the murine retina produces myopia'. Together they form a unique fingerprint.

  • Cite this

    Lee, D., Chakraborty, R., Iuvone, P. M., Stone, R. A., & Pardue, M. T. (2016). Eliminating the mater clock gene in the murine retina produces myopia. Abstract from The Association for Research in Vision and Ophthalmology annual meeting 2012, Fort Lauderdale, United States. https://iovs.arvojournals.org/article.aspx?articleid=2561822&resultClick=1