Eliminating the mater clock gene in the murine retina produces myopia

Duk Lee; Ranjay Chakraborty; P. Michael Iuvone; Richard A. Stone; Machelle T. Pardue

Eliminating the mater clock gene in the murine retina produces myopia

Duk Lee, Ranjay Chakraborty, P. Michael Iuvone, Richard A. Stone, Machelle T. Pardue

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Abstract

BMAL1 is a transcription factor that is essential to the operation of the circadian clock mechanism in all tissues of the body, including the retina. Previous studies with chicks have linked intrinsic retinal circadian rhythms to experimental myopia (Stone et al., 2013). In this study, Cre-mediated, retinal specific BMAL1 knockout (KO) mice were examined to determine whether the BMAL1 gene and, by inference, circadian rhythms have a role in normal refractive development of the eye.

Original language	English
Number of pages	2
Publication status	Published - Sept 2016
Externally published	Yes
Event	The Association for Research in Vision and Ophthalmology annual meeting 2012 - Fort Lauderdale Convention Center, Fort Lauderdale, United States Duration: 6 May 2012 → 10 May 2012 Conference number: 14

Conference

Conference	The Association for Research in Vision and Ophthalmology annual meeting 2012
Abbreviated title	ARVO 2012
Country/Territory	United States
City	Fort Lauderdale
Period	6/05/12 → 10/05/12

Bibliographical note

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. CC BY-NC-ND

Keywords

myopia
BMAL1 gene
mice
retina

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Published versionFinal published version, 60.8 KBLicence: CC BY-NC-ND

https://iovs.arvojournals.org/article.aspx?articleid=2561822&resultClick=1Licence: CC BY-NC-ND

Cite this

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title = "Eliminating the mater clock gene in the murine retina produces myopia",

abstract = "BMAL1 is a transcription factor that is essential to the operation of the circadian clock mechanism in all tissues of the body, including the retina. Previous studies with chicks have linked intrinsic retinal circadian rhythms to experimental myopia (Stone et al., 2013). In this study, Cre-mediated, retinal specific BMAL1 knockout (KO) mice were examined to determine whether the BMAL1 gene and, by inference, circadian rhythms have a role in normal refractive development of the eye.",

keywords = "myopia, BMAL1 gene, mice, retina",

author = "Duk Lee and Ranjay Chakraborty and Iuvone, {P. Michael} and Stone, {Richard A.} and Pardue, {Machelle T.}",

note = "This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. CC BY-NC-ND; The Association for Research in Vision and Ophthalmology annual meeting 2012, ARVO 2012 ; Conference date: 06-05-2012 Through 10-05-2012",

year = "2016",

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language = "English",

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TY - CONF

T1 - Eliminating the mater clock gene in the murine retina produces myopia

AU - Lee, Duk

AU - Chakraborty, Ranjay

AU - Iuvone, P. Michael

AU - Stone, Richard A.

AU - Pardue, Machelle T.

N1 - Conference code: 14

PY - 2016/9

Y1 - 2016/9

N2 - BMAL1 is a transcription factor that is essential to the operation of the circadian clock mechanism in all tissues of the body, including the retina. Previous studies with chicks have linked intrinsic retinal circadian rhythms to experimental myopia (Stone et al., 2013). In this study, Cre-mediated, retinal specific BMAL1 knockout (KO) mice were examined to determine whether the BMAL1 gene and, by inference, circadian rhythms have a role in normal refractive development of the eye.

AB - BMAL1 is a transcription factor that is essential to the operation of the circadian clock mechanism in all tissues of the body, including the retina. Previous studies with chicks have linked intrinsic retinal circadian rhythms to experimental myopia (Stone et al., 2013). In this study, Cre-mediated, retinal specific BMAL1 knockout (KO) mice were examined to determine whether the BMAL1 gene and, by inference, circadian rhythms have a role in normal refractive development of the eye.

KW - myopia

KW - BMAL1 gene

KW - mice

KW - retina

M3 - Abstract

T2 - The Association for Research in Vision and Ophthalmology annual meeting 2012

Y2 - 6 May 2012 through 10 May 2012

ER -

Eliminating the mater clock gene in the murine retina produces myopia

Abstract

Conference

Bibliographical note

Keywords

Access to Document

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Cite this