TY - JOUR
T1 - Emerging Functions for snoRNAs and snoRNA‐Derived Fragments
AU - Wajahat, Maliha
AU - Bracken, Cameron Peter
AU - Orang, Ayla
PY - 2021/10
Y1 - 2021/10
N2 - The widespread implementation of mass sequencing has revealed a diverse landscape of small RNAs derived from larger precursors. Whilst many of these are likely to be byproducts of degradation, there are nevertheless metabolically stable fragments derived from tRNAs, rRNAs, snoRNAs, and other non‐coding RNA, with a number of examples of the production of such fragments being conserved across species. Coupled with specific interactions to RNA‐binding proteins and a growing number of experimentally reported examples suggesting function, a case is emerging whereby the biological significance of small non‐coding RNAs extends far beyond miRNAs and piRNAs. Related to this, a similarly complex picture is emerging of non‐canonical roles for the noncoding precursors, such as for snoRNAs that are also implicated in such areas as the silencing of gene expression and the regulation of alternative splicing. This is in addition to a body of literature describing snoRNAs as an additional source of miRNA‐like regulators. This review seeks to highlight emerging roles for such non‐coding RNA, focusing specifically on “new” roles for snoRNAs and the small fragments derived from them.
AB - The widespread implementation of mass sequencing has revealed a diverse landscape of small RNAs derived from larger precursors. Whilst many of these are likely to be byproducts of degradation, there are nevertheless metabolically stable fragments derived from tRNAs, rRNAs, snoRNAs, and other non‐coding RNA, with a number of examples of the production of such fragments being conserved across species. Coupled with specific interactions to RNA‐binding proteins and a growing number of experimentally reported examples suggesting function, a case is emerging whereby the biological significance of small non‐coding RNAs extends far beyond miRNAs and piRNAs. Related to this, a similarly complex picture is emerging of non‐canonical roles for the noncoding precursors, such as for snoRNAs that are also implicated in such areas as the silencing of gene expression and the regulation of alternative splicing. This is in addition to a body of literature describing snoRNAs as an additional source of miRNA‐like regulators. This review seeks to highlight emerging roles for such non‐coding RNA, focusing specifically on “new” roles for snoRNAs and the small fragments derived from them.
KW - MicroRNAs
KW - Non‐coding RNAs
KW - SdRNAs
KW - SnoRNAs
KW - TRNAs
UR - http://www.scopus.com/inward/record.url?scp=85115372173&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/ARC/FT190100544
UR - http://purl.org/au-research/grants/ARC/DP190103333
U2 - 10.3390/ijms221910193
DO - 10.3390/ijms221910193
M3 - Review article
C2 - 34638533
AN - SCOPUS:85115372173
SN - 1661-6596
VL - 22
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 19
M1 - 10193
ER -