TY - JOUR
T1 - Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection
AU - De Biasi, Sara
AU - Lo Tartaro, Domenico
AU - Gibellini, Lara
AU - Paolini, Annamaria
AU - Quong, Andrew
AU - Petes, Carlene
AU - Awong, Geneve
AU - Douglas, Samuel
AU - Lin, Dongxia
AU - Nieto, Jordan
AU - Galassi, Francesco M
AU - Borella, Rebecca
AU - Fidanza, Lucia
AU - Mattioli, Marco
AU - Leone, Chiara
AU - Neri, Isabella
AU - Meschiari, Marianna
AU - Cicchetti, Luca
AU - Iannone, Anna G.
AU - Trenti, Tommaso
AU - Sarti, Mario
AU - Girardis, Massimo
AU - Guaraldi, Giovanni
AU - Mussini, Cristina
AU - Facchinetti, Fabio
AU - Cossarizza, Andrea
PY - 2021/7/29
Y1 - 2021/7/29
N2 - SARS-CoV-2 infection can affect all human beings, including pregnant women. Thus, understanding the immunological changes induced by the virus during pregnancy is nowadays of pivotal importance. Here, using peripheral blood from 14 pregnant women with asymptomatic or mild SARS-CoV-2 infection, we investigate cell proliferation and cytokine production, measure plasma levels of 62 cytokines, and perform a 38-parameter mass cytometry analysis. Our results show an increase in low density neutrophils but no lymphopenia or gross alterations of white blood cells, which display normal levels of differentiation, activation or exhaustion markers and show well preserved functionality. Meanwhile, the plasma levels of anti-inflammatory cytokines such as interleukin (IL)-1RA, IL-10 and IL-19 are increased, those of IL-17, PD-L1 and D-dimer are decreased, but IL-6 and other inflammatory molecules remain unchanged. Our profiling of antiviral immune responses may thus help develop therapeutic strategies to avoid virus-induced damages during pregnancy.
AB - SARS-CoV-2 infection can affect all human beings, including pregnant women. Thus, understanding the immunological changes induced by the virus during pregnancy is nowadays of pivotal importance. Here, using peripheral blood from 14 pregnant women with asymptomatic or mild SARS-CoV-2 infection, we investigate cell proliferation and cytokine production, measure plasma levels of 62 cytokines, and perform a 38-parameter mass cytometry analysis. Our results show an increase in low density neutrophils but no lymphopenia or gross alterations of white blood cells, which display normal levels of differentiation, activation or exhaustion markers and show well preserved functionality. Meanwhile, the plasma levels of anti-inflammatory cytokines such as interleukin (IL)-1RA, IL-10 and IL-19 are increased, those of IL-17, PD-L1 and D-dimer are decreased, but IL-6 and other inflammatory molecules remain unchanged. Our profiling of antiviral immune responses may thus help develop therapeutic strategies to avoid virus-induced damages during pregnancy.
KW - SARS-Cov-2
KW - Pregnancy
KW - Immunology
KW - inflammation
KW - asymptomatic
KW - cytokines
KW - IL-17 signaling pathway
KW - Neutrophils
KW - translational immunology
KW - viral infection
UR - http://www.scopus.com/inward/record.url?scp=85111480124&partnerID=8YFLogxK
U2 - 10.1038/s41467-021-24940-w
DO - 10.1038/s41467-021-24940-w
M3 - Article
VL - 12
SP - 1
EP - 16
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 4677
ER -