Endothelial serpins - Protectors of the vasculature?

K. D. Forsyth, V. Talbot, I. Beckman

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Vascular damage, initiated by host inflammatory cells, is a component of the pathophysiology of many acute and chronic inflammatory disorders. Neutrophil-mediated tissue damage is mediated primarily by proteinases, particularly elastase and cathepsin G. In this study we have identified endothelial binding of two key serine proteinase inhibitors (serpins), α1- antitrypsin, the inhibitor of elastase, and α1-antichymotrypsin, the inhibitor of cathepsin G. These serpins are shed from the endothelium into the supernatant when neutrophils adherent to the endothelium are activated. Endothelium activated by lipopolysaccharide (LPS) augments this process. Serpin-proteinase complexes activate neutrophils and induce further cytokine release, thereby amplifying inflammatory processes. Strategies aimed at preventing endothelial serpin depletion may help minimize vascular damage during inflammation.

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalClinical and Experimental Immunology
Volume95
Issue number2
Publication statusPublished - Feb 1994
Externally publishedYes

Keywords

  • activation
  • endothelium
  • neutrophil
  • proteinase
  • serpin

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