Enoxacin-induced modification of the susceptibility of bacteria to phagocytic killing

H. Pruul; G. Kriek; P. J. McDonald

doi:10.1093/jac/21.suppl_b.19

Enoxacin-induced modification of the susceptibility of bacteria to phagocytic killing

H. Pruul, G. Kriek, P. J. McDonald

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The effect of enoxacin upon the interaction in vitro of human polymorphonuclear leucocytes with Streptococcus pneumoniae and Pseudomonas aeruginosa was examined. Synergistic killing of these two species of bacteria was observed in the presence of neutrophils and concentrations of enoxacin above the MIC. Enoxacin was able to kill intracellular Str. pneumoniae and Staphylococcus aureus. The activity of glucose-glucose oxidase, and oxygen-dependent bactericidal system which mimics part of the bactericidal system of human neutrophils, was enhanced by pretreatment with enoxacin and several other antibiotics. The effect of antibiotic pretreatment upon the bactericidal activity of an acid extract of neutrophil granules was variable.

Original language	English
Pages (from-to)	19-27
Number of pages	9
Journal	Journal of Antimicrobial Chemotherapy
Volume	21
Issue number	SUPPL. B
DOIs	https://doi.org/10.1093/jac/21.suppl_b.19
Publication status	Published - 1 Jan 1988

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/jac/21.suppl_b.19Licence: In Copyright

Cite this

@article{c9f7b043805441ed87a3280012dd2ef3,

title = "Enoxacin-induced modification of the susceptibility of bacteria to phagocytic killing",

abstract = "The effect of enoxacin upon the interaction in vitro of human polymorphonuclear leucocytes with Streptococcus pneumoniae and Pseudomonas aeruginosa was examined. Synergistic killing of these two species of bacteria was observed in the presence of neutrophils and concentrations of enoxacin above the MIC. Enoxacin was able to kill intracellular Str. pneumoniae and Staphylococcus aureus. The activity of glucose-glucose oxidase, and oxygen-dependent bactericidal system which mimics part of the bactericidal system of human neutrophils, was enhanced by pretreatment with enoxacin and several other antibiotics. The effect of antibiotic pretreatment upon the bactericidal activity of an acid extract of neutrophil granules was variable.",

author = "H. Pruul and G. Kriek and McDonald, {P. J.}",

year = "1988",

month = jan,

day = "1",

doi = "10.1093/jac/21.suppl_b.19",

language = "English",

volume = "21",

pages = "19--27",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press",

number = "SUPPL. B",

}

TY - JOUR

T1 - Enoxacin-induced modification of the susceptibility of bacteria to phagocytic killing

AU - Pruul, H.

AU - Kriek, G.

AU - McDonald, P. J.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - The effect of enoxacin upon the interaction in vitro of human polymorphonuclear leucocytes with Streptococcus pneumoniae and Pseudomonas aeruginosa was examined. Synergistic killing of these two species of bacteria was observed in the presence of neutrophils and concentrations of enoxacin above the MIC. Enoxacin was able to kill intracellular Str. pneumoniae and Staphylococcus aureus. The activity of glucose-glucose oxidase, and oxygen-dependent bactericidal system which mimics part of the bactericidal system of human neutrophils, was enhanced by pretreatment with enoxacin and several other antibiotics. The effect of antibiotic pretreatment upon the bactericidal activity of an acid extract of neutrophil granules was variable.

AB - The effect of enoxacin upon the interaction in vitro of human polymorphonuclear leucocytes with Streptococcus pneumoniae and Pseudomonas aeruginosa was examined. Synergistic killing of these two species of bacteria was observed in the presence of neutrophils and concentrations of enoxacin above the MIC. Enoxacin was able to kill intracellular Str. pneumoniae and Staphylococcus aureus. The activity of glucose-glucose oxidase, and oxygen-dependent bactericidal system which mimics part of the bactericidal system of human neutrophils, was enhanced by pretreatment with enoxacin and several other antibiotics. The effect of antibiotic pretreatment upon the bactericidal activity of an acid extract of neutrophil granules was variable.

UR - http://www.scopus.com/inward/record.url?scp=0023908781&partnerID=8YFLogxK

U2 - 10.1093/jac/21.suppl_b.19

DO - 10.1093/jac/21.suppl_b.19

M3 - Article

C2 - 3129391

AN - SCOPUS:0023908781

SN - 0305-7453

VL - 21

SP - 19

EP - 27

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - SUPPL. B

ER -

Enoxacin-induced modification of the susceptibility of bacteria to phagocytic killing

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this