Entropy Analysis of RR and QT Interval Variability during Orthostatic and Mental Stress in Healthy Subjects

Mathias Baumert, Barbora Czippelova, Anand Ganesan, M Schmidt, Sebastian Zaunseder, Michael Javorka

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    Autonomic activity affects beat-to-beat variability of heart rate and QT interval. The aim of this study was to explore whether entropy measures are suitable to detect changes in neural outflow to the heart elicited by two different stress paradigms. We recorded short-term ECG in 11 normal subjects during an experimental protocol that involved head-up tilt and mental arithmetic stress and computed sample entropy, cross-sample entropy and causal interactions based on conditional entropy from RR and QT interval time series. Head-up tilt resulted in a significant reduction in sample entropy of RR intervals and cross-sample entropy, while mental arithmetic stress resulted in a significant reduction in coupling directed from RR to QT. In conclusion, measures of entropy are suitable to detect changes in neural outflow to the heart and decoupling of repolarisation variability from heart rate variability elicited by orthostatic or mental arithmetic stress.

    Original languageEnglish
    Pages (from-to)6384-6393
    Number of pages10
    JournalEntropy
    Volume16
    Issue number12
    DOIs
    Publication statusPublished - 2014

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