Environmental determinants of islet autoimmunity (ENDIA): A pregnancy to early life cohort study in children at-risk of type 1 diabetes

M Penno, J Couper, M Craig, Peter Colman, W Rawlinson, A Cotterill, Timothy Jones, L Harrison, Peter Baghurst, Simon Barry, F Cameron, J Dodd, C Duran, J Forbes, Maria Makrides, G Morahan, K Nelson, A Nankervis, R Sinnott, J Wentworth

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    Abstract

    Background: The incidence of type 1 diabetes has increased worldwide, particularly in younger children and those with lower genetic susceptibility. These observations suggest factors in the modern environment promote pancreatic islet autoimmunity and destruction of insulin-producing beta cells. The Environmental Determinants of Islet Autoimmunity (ENDIA) Study is investigating candidate environmental exposures and gene-environment interactions that may contribute to the development of islet autoimmunity and type 1 diabetes.Methods/design: ENDIA is the only prospective pregnancy/birth cohort study in the Southern Hemisphere investigating the determinants of type 1 diabetes in at-risk children. The study will recruit 1,400 unborn infants or infants less than six months of age with a first-degree relative (i.e. mother, father or sibling) with type 1 diabetes, across five Australian states. Pregnant mothers/infants will be followed prospectively from early pregnancy through childhood to investigate relationships between genotype, the development of islet autoimmunity (and subsequently type 1 diabetes), and prenatal and postnatal environmental factors. ENDIA will evaluate the microbiome, nutrition, bodyweight/composition, metabolome-lipidome, insulin resistance, innate and adaptive immune function and viral infections. A systems biology approach will be used to integrate these data. Investigation will be by 3-monthly assessments of the mother during pregnancy, then 3-monthly assessments of the child until 24 months of age and 6-monthly thereafter. The primary outcome measure is persistent islet autoimmunity, defined as the presence of autoantibodies to one or more islet autoantigens on consecutive tests.Discussion: Defining gene-environment interactions that initiate and/or promote destruction of the insulin-producing beta cells in early life will inform approaches to primary prevention of type 1 diabetes. The strength of ENDIA is the prospective, comprehensive and frequent systems-wide profiling from early pregnancy through to early childhood, to capture dynamic environmental exposures that may shape the development of islet autoimmunity.Trial registration: Australia New Zealand Clinical Trials Registry ACTRN12613000794707.

    Original languageEnglish
    Article number124
    Pages (from-to)1-15
    Number of pages15
    JournalBMC Paediatrics
    Volume13
    Issue number124
    DOIs
    Publication statusPublished - 2013

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    Penno, M., Couper, J., Craig, M., Colman, P., Rawlinson, W., Cotterill, A., Jones, T., Harrison, L., Baghurst, P., Barry, S., Cameron, F., Dodd, J., Duran, C., Forbes, J., Makrides, M., Morahan, G., Nelson, K., Nankervis, A., Sinnott, R., & Wentworth, J. (2013). Environmental determinants of islet autoimmunity (ENDIA): A pregnancy to early life cohort study in children at-risk of type 1 diabetes. BMC Paediatrics, 13(124), 1-15. [124]. https://doi.org/10.1186/1471-2431-13-124