Eph receptors as therapeutic targets in glioblastoma

B. W. Day; B. W. Stringer; A. W. Boyd

doi:10.1038/bjc.2014.73

Eph receptors as therapeutic targets in glioblastoma

B. W. Day, B. W. Stringer, A. W. Boyd

Research output: Contribution to journal › Review article › peer-review

60 Citations (Scopus)

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Abstract

The dismal outlook for patients with the most aggressive and common form of adult brain cancer, glioblastoma (GBM), motivates a search for new therapeutic strategies and targets for this aggressive disease. Here we review the findings to date on the role of Eph family receptor tyrosine kinases and their ephrin ligands in brain cancer. Expression of the Eph family of cell surface proteins is generally downregulated to very low levels in normal adult tissues making them particularly attractive for directed therapeutic targeting. Recent Eph targeting studies in pre-clinical models of GBM have been very encouraging and may provide an avenue to treat these highly refractory aggressive tumours.

Original language	English
Pages (from-to)	1255-1261
Number of pages	7
Journal	British Journal of Cancer
Volume	111
Issue number	7
DOIs	https://doi.org/10.1038/bjc.2014.73
Publication status	Published - 23 Sept 2014
Externally published	Yes

Bibliographical note

This work is licensed under the Creative Commons
Attribution-NonCommercial-Share Alike 3.0 Unported
License. To view a copy of this license, visit http://creativecommons.
org/licenses/by-nc-sa/3.0/

Keywords

Eph receptors
brain cancer
glioma
glioblastoma (GBM)
therapeutic targeting

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Eph receptors as therapeutic targets in glioblastoma

Abstract

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Keywords

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