@article{ee26e41c485d4b63b68ebe65e6f0f840,
title = "Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries",
abstract = "Background: To better understand the epidemiology and patterns of tracheostomy practice for patients with acute respiratory distress syndrome (ARDS), we investigated the current usage of tracheostomy in patients with ARDS recruited into the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG-SAFE) study. Methods: This is a secondary analysis of LUNG-SAFE, an international, multicenter, prospective cohort study of patients receiving invasive or noninvasive ventilation in 50 countries spanning 5 continents. The study was carried out over 4 weeks consecutively in the winter of 2014, and 459 ICUs participated. We evaluated the clinical characteristics, management and outcomes of patients that received tracheostomy, in the cohort of patients that developed ARDS on day 1-2 of acute hypoxemic respiratory failure, and in a subsequent propensity-matched cohort. Results: Of the 2377 patients with ARDS that fulfilled the inclusion criteria, 309 (13.0%) underwent tracheostomy during their ICU stay. Patients from high-income European countries (n = 198/1263) more frequently underwent tracheostomy compared to patients from non-European high-income countries (n = 63/649) or patients from middle-income countries (n = 48/465). Only 86/309 (27.8%) underwent tracheostomy on or before day 7, while the median timing of tracheostomy was 14 (Q1-Q3, 7-21) days after onset of ARDS. In the subsample matched by propensity score, ICU and hospital stay were longer in patients with tracheostomy. While patients with tracheostomy had the highest survival probability, there was no difference in 60-day or 90-day mortality in either the patient subgroup that survived for at least 5 days in ICU, or in the propensity-matched subsample. Conclusions: Most patients that receive tracheostomy do so after the first week of critical illness. Tracheostomy may prolong patient survival but does not reduce 60-day or 90-day mortality. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013.",
keywords = "Acute respiratory distress syndrome (ARDS), ICU, Propensity-matched analysis, Tracheostomy, Ventilation",
author = "Toshikazu Abe and Fabiana Madotto and T{\`a}i Pham and Isao Nagata and Masatoshi Uchida and Nanako Tamiya and Kiyoyasu Kurahashi and Giacomo Bellani and Laffey, {John G.} and {LUNG SAFE Investigators} and {ESICM Trials Group} and Francois, {G. M.} and F. Rabboni and S. Conti and E. Fan and A. Pesenti and L. Brochard and A. Esteban and L. Gattinoni and {van Haren}, F. and A. Larsson and McAuley, {D. F.} and M. Ranieri and G. Rubenfeld and Thompson, {B. T.} and H. Wrigge and Slutsky, {A. S.} and F. Rios and T. Sottiaux and P. Depuydt and Lora, {F. S.} and Azevedo, {L. C.} and G. Bugedo and H. Qiu and M. Gonzalez and J. Silesky and V. Cerny and J. Nielsen and M. Jibaja and D. Matamis and Ranero, {J. L.} and P. Amin and Hashemian, {S. M.} and K. Clarkson and A. Villagomez and Zeggwagh, {A. A.} and Heunks, {L. M.} and Laake, {J. H.} and Palo, {J. E.} and {do Vale Fernandes}, A. and D. Sandesc and Y. Arabi and V. Bumbasierevic and N. Nin and Lorente, {J. A.} and L. Piquilloud and F. Abroug and L. McNamee and J. Hurtado and E. Bajwa and G. D{\'e}mpair and H. Sula and L. Nunci and A. Cani and A. Zazu and C. Dellera and Insaurralde, {C. S.} and Alejandro, {R. V.} and J. Daldin and M. Vinzio and Fernandez, {R. O.} and Cardonnet, {L. P.} and Bettini, {L. R.} and Bisso, {M. C.} and Osman, {E. M.} and Setten, {M. G.} and P. Lovazzano and J. Alvarez and V. Villar and Pozo, {N. C.} and N. Grubissich and Plotnikow, {G. A.} and Vasquez, {D. N.} and S. Ilutovich and N. Tiribelli and A. Chena and Pellegrini, {C. A.} and Saenz, {M. G.} and E. Estenssoro and M. Brizuela and H. Gianinetto and Gomez, {P. E.} and Cerrato, {V. I.} and Bezzi, {M. G.} and Borello, {S. A.} and Loiacono, {F. A.} and Fernandez, {A. M.} and S. Knowles and C. Reynolds and Inskip, {D. M.} and Miller, {J. J.} and J. Kong and C. Whitehead and S. Bihari and A. Seven and A. Krstevski and Rodgers, {H. J.} and Millar, {R. T.} and Mckenna, {T. E.} and Bailey, {I. M.} and Hanlon, {G. C.} and A. Aneman and Lynch, {J. M.} and R. Azad and J. Neal and Woods, {P. W.} and Roberts, {B. L.} and Kol, {M. R.} and Wong, {H. S.} and Riss, {K. C.} and T. Staudinger and X. Wittebole and C. Berghe and Bulpa, {P. A.} and Dive, {A. M.} and R. Verstraete and H. Lebbinck and P. Depuydt and J. Vermassen and P. Meersseman and H. Ceunen and Rosa, {J. I.} and Beraldo, {D. O.} and C. Piras and Rampinelli, {A. M.} and Nassar, {A. P.} and S. Mataloun and M. Moock and Thompson, {M. M.} and Gon{\c c}alves, {C. H.} and ACP Ant{\^o}nio and A. Ascoli and Biondi, {R. S.} and Fontenele, {D. C.} and D. Nobrega and Sales, {V. M.} and S. Shindhe and DHMABPH Ismail and F. Beloncle and Davies, {K. G.} and R. Cirone and V. Manoharan and M. Ismail and Goligher, {E. C.} and M. Jassal and E. Nishikawa and A. Javeed and G. Curley and N. Rittayamai and M. Parotto and Ferguson, {N. D.} and S. Mehta and J. Knoll and A. Pronovost and S. Canestrini and Bruhn, {A. R.} and Garcia, {P. H.} and Aliaga, {F. A.} and Far{\'i}as, {P. A.} and Yumha, {J. S.} and Ortiz, {C. A.} and Salas, {J. E.} and Saez, {A. A.} and Vega, {L. D.} and Labarca, {E. F.} and Martinez, {F. T.} and Carre{\~n}o, {N. G.} and P. Lora and H. Liu and L. Liu and R. Tang and X. Luo and Y. An and H. Zhao and Y. Gao and Z. Zhai and Ye, {Z. L.} and W. Wang and W. Li and Q. Li and R. Zheng and W. Yu and J. Shen and X. Li and T. Yu and W. Lu and Wu, {Y. Q.} and Huang, {X. B.} and Z. He and Y. Lu and H. Han and F. Zhang and R. Sun and Wang, {H. X.} and Qin, {S. H.} and Zhu, {B. H.} and J. Zhao and J. Liu and B. Li and Liu, {J. L.} and Zhou, {F. C.} and Li, {Q. J.} and Zhang, {X. Y.} and Z. Li-Xin and Q. Xin-Hua and L. Jiang and Gao, {Y. N.} and Zhao, {X. Y.} and Y. Li and Li, {X. L.} and C. Wang and Q. Yao and R. Yu and K. Chen and H. Shao and B. Qin and Huang, {Q. Q.} and Zhu, {W. H.} and Hang, {A. Y.} and Hua, {M. X.} and Y. Li and Y. Xu and Di, {Y. D.} and Ling, {L. L.} and Qin, {T. H.} and Wang, {S. H.} and J. Qin and Y. Han and Suming Zhou and Vargas, {M. P.} and {Silesky Jimenez}, {J. I.} and {Gonz{\'a}lez Rojas}, {M. A.} and Solis-Quesada, {J. E.} and Ramirez-Alfaro, {C. M.} and J. M{\'a}ca and P. Sklienka and J. Gjedsted and Aage Christiansen and Jonas Nielsen and Villamagua, {B. G.} and M. Llano and P. Burtin and G. Buzancais and P. Beuret and N. Pelletier",
note = "This article is distributed under the terms of the Creative Commons Attribution 4.0International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated",
year = "2018",
month = aug,
day = "17",
doi = "10.1186/s13054-018-2126-6",
language = "English",
volume = "22",
journal = "Critical Care",
issn = "1364-8535",
publisher = "BioMed Central Ltd.",
number = "1",
}