Epigenetic biomarkers in prostate cancer: Current and future uses.

Karen Chiam, Carmella Ricciardelli, Tina Bianco-Miotto

    Research output: Contribution to journalArticle

    52 Citations (Scopus)

    Abstract

    Epigenome alterations are characteristic of nearly all human malignancies and include changes in DNA methylation, histone modifications and microRNAs (miRNAs). However, what induces these epigenetic alterations in cancer is largely unknown and their mechanistic role in prostate tumorigenesis is just beginning to be evaluated. Identification of the epigenetic modifications involved in the development and progression of prostate cancer will not only identify novel therapeutic targets but also prognostic and diagnostic markers. This review will focus on the use of epigenetic modifications as biomarkers for prostate cancer.

    Original languageEnglish
    Pages (from-to)248-256
    Number of pages9
    JournalCancer Letters
    Volume342
    Issue number2
    DOIs
    Publication statusPublished - 2014

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