EpiNet as a way of involving more physicians and patients in epilepsy research: Validation study and accreditation process

Peter S. Bergin; Ettore Beghi; Lynette G. Sadleir; Alice Brockington; Manjari Tripathi; Mark P. Richardson; Elisa Bianchi; Kavita Srivastava; Jayaganth Jayabal; Benjamin Legros; Michel Ossemann; Nicole McGrath; Alberto Verrotti; Hui Jan Tan; Simone Beretta; Richard Frith; Ivan Iniesta; Emma Whitham; Jithangi Wanigasinghe; Birinus Ezeala-Adikaibe; Pasquale Striano; Ian Rosemergy; Elizabeth B. Walker; Maia Alkhidze; Ildefonso Rodriguez-Leyva; Jose Alfredo Ramírez González; Wendyl J. D'Souza; on behalf of the EpiNet Study Group; Analía Calle; Claudio Palacios; Anita Cairns; Patrick Carney; Donald Craig; Deepak Gill; Sachin Gupta; Cecilie Lander; Hanka Laue-Gizzi; Natalie Hitchens; Michelle Kiley; Nicholas Lawn; Elizabeth Reyneke; Kate Riney; Meng Tan; Michael Tan; Mark Thieban; Chong Wong; Germain van Rijckevorsel; Ana Gabriela Ferrari Strang; Angela Gifoni; Linden Helio; Bruno Monnerat; Paula Brna; Elizabeth Donner; Stephanie Jacques; Nathalie Jette; Richard McLachlan; Ismail Mohamed; Thi Phuoc Yen Tran; Xiao Bo; Song Fan; Yang Guang; Ming Li; Kang Wang; Shouwen Zhang; Lady Ladino; Jakob Christensen; Margarethe Sophie Kӧlmel; Marina Nikanorova; Annukka Uusitalo; Paivi Vieira; Stephane Auvin; Tamar Ediberidze; Nino Gogatishvili; Tamar Jishkariani; Dieter Dennig; Anja Grimmer; Rosa Michaelis; Susanne Schubert-Bast; Caspar Stephani; Stefan Stodieck; Martin Vollbrandt; Andreas Zellner; Dimitrios Zafeiriou; Andras Fogarasi; Peter Halasz; Rameshwar Nath Chaurasia; Satish Jain; Raj Nair; Pravar Passi; Surekha Rajadhyaksha; Sita Jayalakshmi Sattaluri; Harshuti Shah; Vrajesh Udani; Daniel Costello; Umberto Aguglia; Arnaldo Bartocci; Paolo Benna; Edoardo Ferlazzo; Daniela Laino; Alberto Spalice; Clara Zanchi; Amza Ali; Kheng Seang Lim; Alfredo Ramirez; Neil Anderson; Alan Barber; Pietro Cariga; James Cleland; Nicholas Child; Suzanne Davis; Viswas Dayal; Cameron Dickson; John Doran; Roderick Duncan; Pratima Giri; Michael Herd; David Hutchinson; Bethany Jones; Justin Kao; Dean Kilfoyle; John Mottershead; Colette Muir; Melinda Nolan; Jennifer Pereira; Anna Ranta; Sneha Sadani; Mark Simpson; Claire Spooner; Paul Timmings; Elizabeth Walker; Diana Wei; Ernest Willoughby; Edward Wong; Teddy Wu; Talabi Olusola; Hiba Mahmud; Zarine Mogul; Julio Espinoza; Jose Hernandez Vizarreta; Elia Maria Baeta; Rute Teotónio; Bosanka Jocic-Jakubi; Stevo Lukic; Marko Korošec; Tomaz Zgur; María Gómez Eguílaz; Fredrik Asztely; Pasiri Sithinamsuwan; Joseph Anderson; Pauls Auce; Archana Desurkar; Khalid Hamandi; Andrew Kelso; Violeta Sanchez; Aurangzeb Sidra; Phil Smith; Tim Wehner; Gavin Winston; Edgard Andrade; Meriem Bensalem-Owen; Michelle Boudreau; Tracie Caller; Kevin Chapman; Geetha Chari; Kathryn Davis; Brian Droker; Mirret El-Hagrassy; Dawn Eliashiv; Chigolum Eze; Christi Heck; Arif Kabir; Dmitriy Kolesnik; Alice Lam; Jonathan Lopez; Tammaa Maamoon; Jennifer Madan Cohen; Rama Maganti; Chinasa Nwankwo; Kristen Park; Simona Proteasa; Evan Sandok; Syndi Seinfield; Julia Toub; Elaine Wirrell; Marcela Arbildi; Truong Tran Thien

doi:10.1002/epi4.12033

EpiNet as a way of involving more physicians and patients in epilepsy research: Validation study and accreditation process

Peter S. Bergin, Ettore Beghi, Lynette G. Sadleir, Alice Brockington, Manjari Tripathi, Mark P. Richardson, Elisa Bianchi, Kavita Srivastava, Jayaganth Jayabal, Benjamin Legros, Michel Ossemann, Nicole McGrath, Alberto Verrotti, Hui Jan Tan, Simone Beretta, Richard Frith, Ivan Iniesta, Emma Whitham, Jithangi Wanigasinghe, Birinus Ezeala-AdikaibePasquale Striano, Ian Rosemergy, Elizabeth B. Walker, Maia Alkhidze, Ildefonso Rodriguez-Leyva, Jose Alfredo Ramírez González, Wendyl J. D'Souza, on behalf of the EpiNet Study Group, Analía Calle, Claudio Palacios, Anita Cairns, Patrick Carney, Donald Craig, Deepak Gill, Sachin Gupta, Cecilie Lander, Hanka Laue-Gizzi, Natalie Hitchens, Michelle Kiley, Nicholas Lawn, Elizabeth Reyneke, Kate Riney, Meng Tan, Michael Tan, Mark Thieban, Chong Wong, Germain van Rijckevorsel, Ana Gabriela Ferrari Strang, Angela Gifoni, Linden Helio, Bruno Monnerat, Paula Brna, Elizabeth Donner, Stephanie Jacques, Nathalie Jette, Richard McLachlan, Ismail Mohamed, Thi Phuoc Yen Tran, Xiao Bo, Song Fan, Yang Guang, Ming Li, Kang Wang, Shouwen Zhang, Lady Ladino, Jakob Christensen, Margarethe Sophie Kӧlmel, Marina Nikanorova, Annukka Uusitalo, Paivi Vieira, Stephane Auvin, Tamar Ediberidze, Nino Gogatishvili, Tamar Jishkariani, Dieter Dennig, Anja Grimmer, Rosa Michaelis, Susanne Schubert-Bast, Caspar Stephani, Stefan Stodieck, Martin Vollbrandt, Andreas Zellner, Dimitrios Zafeiriou, Andras Fogarasi, Peter Halasz, Rameshwar Nath Chaurasia, Satish Jain, Raj Nair, Pravar Passi, Surekha Rajadhyaksha, Sita Jayalakshmi Sattaluri, Harshuti Shah, Vrajesh Udani, Daniel Costello, Umberto Aguglia, Arnaldo Bartocci, Paolo Benna, Edoardo Ferlazzo, Daniela Laino, Alberto Spalice, Clara Zanchi, Amza Ali, Kheng Seang Lim, Alfredo Ramirez, Neil Anderson, Alan Barber, Pietro Cariga, James Cleland, Nicholas Child, Suzanne Davis, Viswas Dayal, Cameron Dickson, John Doran, Roderick Duncan, Pratima Giri, Michael Herd, David Hutchinson, Bethany Jones, Justin Kao, Dean Kilfoyle, John Mottershead, Colette Muir, Melinda Nolan, Jennifer Pereira, Anna Ranta, Sneha Sadani, Mark Simpson, Claire Spooner, Paul Timmings, Elizabeth Walker, Diana Wei, Ernest Willoughby, Edward Wong, Teddy Wu, Talabi Olusola, Hiba Mahmud, Zarine Mogul, Julio Espinoza, Jose Hernandez Vizarreta, Elia Maria Baeta, Rute Teotónio, Bosanka Jocic-Jakubi, Stevo Lukic, Marko Korošec, Tomaz Zgur, María Gómez Eguílaz, Fredrik Asztely, Pasiri Sithinamsuwan, Joseph Anderson, Pauls Auce, Archana Desurkar, Khalid Hamandi, Andrew Kelso, Violeta Sanchez, Aurangzeb Sidra, Phil Smith, Tim Wehner, Gavin Winston, Edgard Andrade, Meriem Bensalem-Owen, Michelle Boudreau, Tracie Caller, Kevin Chapman, Geetha Chari, Kathryn Davis, Brian Droker, Mirret El-Hagrassy, Dawn Eliashiv, Chigolum Eze, Christi Heck, Arif Kabir, Dmitriy Kolesnik, Alice Lam, Jonathan Lopez, Tammaa Maamoon, Jennifer Madan Cohen, Rama Maganti, Chinasa Nwankwo, Kristen Park, Simona Proteasa, Evan Sandok, Syndi Seinfield, Julia Toub, Elaine Wirrell, Marcela Arbildi, Truong Tran Thien

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective: EpiNet was established to encourage epilepsy research. EpiNet is used for multicenter cohort studies and investigator-led trials. Physicians must be accredited to recruit patients into trials. Here, we describe the accreditation process for the EpiNet-First trials. Methods: Physicians with an interest in epilepsy were invited to assess 30 case scenarios to determine the following: whether patients have epilepsy; the nature of the seizures (generalized, focal); and the etiology. Information was presented in two steps for 23 cases. The EpiNet steering committee determined that 21 cases had epilepsy. The steering committee determined by consensus which responses were acceptable for each case. We chose a subset of 18 cases to accredit investigators for the EpiNet-First trials. We initially focused on 12 cases; to be accredited, investigators could not diagnose epilepsy in any case that the steering committee determined did not have epilepsy. If investigators were not accredited after assessing 12 cases, 6 further cases were considered. When assessing the 18 cases, investigators could be accredited if they diagnosed one of six nonepilepsy patients as having possible epilepsy but could make no other false-positive errors and could make only one error regarding seizure classification. Results: Between December 2013 and December 2014, 189 physicians assessed the 30 cases. Agreement with the steering committee regarding the diagnosis at step 1 ranged from 47% to 100%, and improved when information regarding tests was provided at step 2. One hundred five of the 189 physicians (55%) were accredited for the EpiNet-First trials. The kappa value for diagnosis of epilepsy across all 30 cases for accredited physicians was 0.70. Significance: We have established criteria for accrediting physicians using EpiNet. New investigators can be accredited by assessing 18 case scenarios. We encourage physicians with an interest in epilepsy to become EpiNet-accredited and to participate in these investigator-led clinical trials.

Original language	English
Pages (from-to)	20-31
Number of pages	12
Journal	Epilepsia Open
Volume	2
Issue number	1
DOIs	https://doi.org/10.1002/epi4.12033
Publication status	Published - Mar 2017

Keywords

Accreditation
Clinical trials
Diagnostic accuracy
Multicenter collaboration

Access to Document

10.1002/epi4.12033Licence: CC BY-NC-ND

Published versionFinal published version, 187 KBLicence: CC BY-NC-ND

Cite this

Bergin, P. S., Beghi, E., Sadleir, L. G., Brockington, A., Tripathi, M., Richardson, M. P., Bianchi, E., Srivastava, K., Jayabal, J., Legros, B., Ossemann, M., McGrath, N., Verrotti, A., Tan, H. J., Beretta, S., Frith, R., Iniesta, I., Whitham, E., Wanigasinghe, J., ... Thien, T. T. (2017). EpiNet as a way of involving more physicians and patients in epilepsy research: Validation study and accreditation process. Epilepsia Open, 2(1), 20-31. https://doi.org/10.1002/epi4.12033

@article{ad2ec781508645c4ac3477c935518da5,

title = "EpiNet as a way of involving more physicians and patients in epilepsy research: Validation study and accreditation process",

abstract = "Objective: EpiNet was established to encourage epilepsy research. EpiNet is used for multicenter cohort studies and investigator-led trials. Physicians must be accredited to recruit patients into trials. Here, we describe the accreditation process for the EpiNet-First trials. Methods: Physicians with an interest in epilepsy were invited to assess 30 case scenarios to determine the following: whether patients have epilepsy; the nature of the seizures (generalized, focal); and the etiology. Information was presented in two steps for 23 cases. The EpiNet steering committee determined that 21 cases had epilepsy. The steering committee determined by consensus which responses were acceptable for each case. We chose a subset of 18 cases to accredit investigators for the EpiNet-First trials. We initially focused on 12 cases; to be accredited, investigators could not diagnose epilepsy in any case that the steering committee determined did not have epilepsy. If investigators were not accredited after assessing 12 cases, 6 further cases were considered. When assessing the 18 cases, investigators could be accredited if they diagnosed one of six nonepilepsy patients as having possible epilepsy but could make no other false-positive errors and could make only one error regarding seizure classification. Results: Between December 2013 and December 2014, 189 physicians assessed the 30 cases. Agreement with the steering committee regarding the diagnosis at step 1 ranged from 47% to 100%, and improved when information regarding tests was provided at step 2. One hundred five of the 189 physicians (55%) were accredited for the EpiNet-First trials. The kappa value for diagnosis of epilepsy across all 30 cases for accredited physicians was 0.70. Significance: We have established criteria for accrediting physicians using EpiNet. New investigators can be accredited by assessing 18 case scenarios. We encourage physicians with an interest in epilepsy to become EpiNet-accredited and to participate in these investigator-led clinical trials.",

keywords = "Accreditation, Clinical trials, Diagnostic accuracy, Multicenter collaboration",

author = "Bergin, {Peter S.} and Ettore Beghi and Sadleir, {Lynette G.} and Alice Brockington and Manjari Tripathi and Richardson, {Mark P.} and Elisa Bianchi and Kavita Srivastava and Jayaganth Jayabal and Benjamin Legros and Michel Ossemann and Nicole McGrath and Alberto Verrotti and Tan, {Hui Jan} and Simone Beretta and Richard Frith and Ivan Iniesta and Emma Whitham and Jithangi Wanigasinghe and Birinus Ezeala-Adikaibe and Pasquale Striano and Ian Rosemergy and Walker, {Elizabeth B.} and Maia Alkhidze and Ildefonso Rodriguez-Leyva and {Ram{\'i}rez Gonz{\'a}lez}, {Jose Alfredo} and D'Souza, {Wendyl J.} and {on behalf of the EpiNet Study Group} and Anal{\'i}a Calle and Claudio Palacios and Anita Cairns and Patrick Carney and Donald Craig and Deepak Gill and Sachin Gupta and Cecilie Lander and Hanka Laue-Gizzi and Natalie Hitchens and Michelle Kiley and Nicholas Lawn and Elizabeth Reyneke and Kate Riney and Meng Tan and Michael Tan and Mark Thieban and Chong Wong and {van Rijckevorsel}, Germain and {Ferrari Strang}, {Ana Gabriela} and Angela Gifoni and Linden Helio and Bruno Monnerat and Paula Brna and Elizabeth Donner and Stephanie Jacques and Nathalie Jette and Richard McLachlan and Ismail Mohamed and Tran, {Thi Phuoc Yen} and Xiao Bo and Song Fan and Yang Guang and Ming Li and Kang Wang and Shouwen Zhang and Lady Ladino and Jakob Christensen and Kӧlmel, {Margarethe Sophie} and Marina Nikanorova and Annukka Uusitalo and Paivi Vieira and Stephane Auvin and Tamar Ediberidze and Nino Gogatishvili and Tamar Jishkariani and Dieter Dennig and Anja Grimmer and Rosa Michaelis and Susanne Schubert-Bast and Caspar Stephani and Stefan Stodieck and Martin Vollbrandt and Andreas Zellner and Dimitrios Zafeiriou and Andras Fogarasi and Peter Halasz and Chaurasia, {Rameshwar Nath} and Satish Jain and Raj Nair and Pravar Passi and Surekha Rajadhyaksha and Sattaluri, {Sita Jayalakshmi} and Harshuti Shah and Vrajesh Udani and Daniel Costello and Umberto Aguglia and Arnaldo Bartocci and Paolo Benna and Edoardo Ferlazzo and Daniela Laino and Alberto Spalice and Clara Zanchi and Amza Ali and Lim, {Kheng Seang} and Alfredo Ramirez and Neil Anderson and Alan Barber and Pietro Cariga and James Cleland and Nicholas Child and Suzanne Davis and Viswas Dayal and Cameron Dickson and John Doran and Roderick Duncan and Pratima Giri and Michael Herd and David Hutchinson and Bethany Jones and Justin Kao and Dean Kilfoyle and John Mottershead and Colette Muir and Melinda Nolan and Jennifer Pereira and Anna Ranta and Sneha Sadani and Mark Simpson and Claire Spooner and Paul Timmings and Elizabeth Walker and Diana Wei and Ernest Willoughby and Edward Wong and Teddy Wu and Talabi Olusola and Hiba Mahmud and Zarine Mogul and Julio Espinoza and Vizarreta, {Jose Hernandez} and Baeta, {Elia Maria} and Rute Teot{\'o}nio and Bosanka Jocic-Jakubi and Stevo Lukic and Marko Koro{\v s}ec and Tomaz Zgur and Egu{\'i}laz, {Mar{\'i}a G{\'o}mez} and Fredrik Asztely and Pasiri Sithinamsuwan and Joseph Anderson and Pauls Auce and Archana Desurkar and Khalid Hamandi and Andrew Kelso and Violeta Sanchez and Aurangzeb Sidra and Phil Smith and Tim Wehner and Gavin Winston and Edgard Andrade and Meriem Bensalem-Owen and Michelle Boudreau and Tracie Caller and Kevin Chapman and Geetha Chari and Kathryn Davis and Brian Droker and Mirret El-Hagrassy and Dawn Eliashiv and Chigolum Eze and Christi Heck and Arif Kabir and Dmitriy Kolesnik and Alice Lam and Jonathan Lopez and Tammaa Maamoon and Cohen, {Jennifer Madan} and Rama Maganti and Chinasa Nwankwo and Kristen Park and Simona Proteasa and Evan Sandok and Syndi Seinfield and Julia Toub and Elaine Wirrell and Marcela Arbildi and Thien, {Truong Tran}",

year = "2017",

month = mar,

doi = "10.1002/epi4.12033",

language = "English",

volume = "2",

pages = "20--31",

journal = "Epilepsia Open",

issn = "2470-9239",

number = "1",

}

Bergin, PS, Beghi, E, Sadleir, LG, Brockington, A, Tripathi, M, Richardson, MP, Bianchi, E, Srivastava, K, Jayabal, J, Legros, B, Ossemann, M, McGrath, N, Verrotti, A, Tan, HJ, Beretta, S, Frith, R, Iniesta, I, Whitham, E, Wanigasinghe, J, Ezeala-Adikaibe, B, Striano, P, Rosemergy, I, Walker, EB, Alkhidze, M, Rodriguez-Leyva, I, Ramírez González, JA, D'Souza, WJ, on behalf of the EpiNet Study Group, Calle, A, Palacios, C, Cairns, A, Carney, P, Craig, D, Gill, D, Gupta, S, Lander, C, Laue-Gizzi, H, Hitchens, N, Kiley, M, Lawn, N, Reyneke, E, Riney, K, Tan, M, Tan, M, Thieban, M, Wong, C, van Rijckevorsel, G, Ferrari Strang, AG, Gifoni, A, Helio, L, Monnerat, B, Brna, P, Donner, E, Jacques, S, Jette, N, McLachlan, R, Mohamed, I, Tran, TPY, Bo, X, Fan, S, Guang, Y, Li, M, Wang, K, Zhang, S, Ladino, L, Christensen, J, Kӧlmel, MS, Nikanorova, M, Uusitalo, A, Vieira, P, Auvin, S, Ediberidze, T, Gogatishvili, N, Jishkariani, T, Dennig, D, Grimmer, A, Michaelis, R, Schubert-Bast, S, Stephani, C, Stodieck, S, Vollbrandt, M, Zellner, A, Zafeiriou, D, Fogarasi, A, Halasz, P, Chaurasia, RN, Jain, S, Nair, R, Passi, P, Rajadhyaksha, S, Sattaluri, SJ, Shah, H, Udani, V, Costello, D, Aguglia, U, Bartocci, A, Benna, P, Ferlazzo, E, Laino, D, Spalice, A, Zanchi, C, Ali, A, Lim, KS, Ramirez, A, Anderson, N, Barber, A, Cariga, P, Cleland, J, Child, N, Davis, S, Dayal, V, Dickson, C, Doran, J, Duncan, R, Giri, P, Herd, M, Hutchinson, D, Jones, B, Kao, J, Kilfoyle, D, Mottershead, J, Muir, C, Nolan, M, Pereira, J, Ranta, A, Sadani, S, Simpson, M, Spooner, C, Timmings, P, Walker, E, Wei, D, Willoughby, E, Wong, E, Wu, T, Olusola, T, Mahmud, H, Mogul, Z, Espinoza, J, Vizarreta, JH, Baeta, EM, Teotónio, R, Jocic-Jakubi, B, Lukic, S, Korošec, M, Zgur, T, Eguílaz, MG, Asztely, F, Sithinamsuwan, P, Anderson, J, Auce, P, Desurkar, A, Hamandi, K, Kelso, A, Sanchez, V, Sidra, A, Smith, P, Wehner, T, Winston, G, Andrade, E, Bensalem-Owen, M, Boudreau, M, Caller, T, Chapman, K, Chari, G, Davis, K, Droker, B, El-Hagrassy, M, Eliashiv, D, Eze, C, Heck, C, Kabir, A, Kolesnik, D, Lam, A, Lopez, J, Maamoon, T, Cohen, JM, Maganti, R, Nwankwo, C, Park, K, Proteasa, S, Sandok, E, Seinfield, S, Toub, J, Wirrell, E, Arbildi, M & Thien, TT 2017, 'EpiNet as a way of involving more physicians and patients in epilepsy research: Validation study and accreditation process', Epilepsia Open, vol. 2, no. 1, pp. 20-31. https://doi.org/10.1002/epi4.12033

TY - JOUR

T1 - EpiNet as a way of involving more physicians and patients in epilepsy research

T2 - Validation study and accreditation process

AU - Bergin, Peter S.

AU - Beghi, Ettore

AU - Sadleir, Lynette G.

AU - Brockington, Alice

AU - Tripathi, Manjari

AU - Richardson, Mark P.

AU - Bianchi, Elisa

AU - Srivastava, Kavita

AU - Jayabal, Jayaganth

AU - Legros, Benjamin

AU - Ossemann, Michel

AU - McGrath, Nicole

AU - Verrotti, Alberto

AU - Tan, Hui Jan

AU - Beretta, Simone

AU - Frith, Richard

AU - Iniesta, Ivan

AU - Whitham, Emma

AU - Wanigasinghe, Jithangi

AU - Ezeala-Adikaibe, Birinus

AU - Striano, Pasquale

AU - Rosemergy, Ian

AU - Walker, Elizabeth B.

AU - Alkhidze, Maia

AU - Rodriguez-Leyva, Ildefonso

AU - Ramírez González, Jose Alfredo

AU - D'Souza, Wendyl J.

AU - on behalf of the EpiNet Study Group

AU - Calle, Analía

AU - Palacios, Claudio

AU - Cairns, Anita

AU - Carney, Patrick

AU - Craig, Donald

AU - Gill, Deepak

AU - Gupta, Sachin

AU - Lander, Cecilie

AU - Laue-Gizzi, Hanka

AU - Hitchens, Natalie

AU - Kiley, Michelle

AU - Lawn, Nicholas

AU - Reyneke, Elizabeth

AU - Riney, Kate

AU - Tan, Meng

AU - Tan, Michael

AU - Thieban, Mark

AU - Wong, Chong

AU - van Rijckevorsel, Germain

AU - Ferrari Strang, Ana Gabriela

AU - Gifoni, Angela

AU - Helio, Linden

AU - Monnerat, Bruno

AU - Brna, Paula

AU - Donner, Elizabeth

AU - Jacques, Stephanie

AU - Jette, Nathalie

AU - McLachlan, Richard

AU - Mohamed, Ismail

AU - Tran, Thi Phuoc Yen

AU - Bo, Xiao

AU - Fan, Song

AU - Guang, Yang

AU - Li, Ming

AU - Wang, Kang

AU - Zhang, Shouwen

AU - Ladino, Lady

AU - Christensen, Jakob

AU - Kӧlmel, Margarethe Sophie

AU - Nikanorova, Marina

AU - Uusitalo, Annukka

AU - Vieira, Paivi

AU - Auvin, Stephane

AU - Ediberidze, Tamar

AU - Gogatishvili, Nino

AU - Jishkariani, Tamar

AU - Dennig, Dieter

AU - Grimmer, Anja

AU - Michaelis, Rosa

AU - Schubert-Bast, Susanne

AU - Stephani, Caspar

AU - Stodieck, Stefan

AU - Vollbrandt, Martin

AU - Zellner, Andreas

AU - Zafeiriou, Dimitrios

AU - Fogarasi, Andras

AU - Halasz, Peter

AU - Chaurasia, Rameshwar Nath

AU - Jain, Satish

AU - Nair, Raj

AU - Passi, Pravar

AU - Rajadhyaksha, Surekha

AU - Sattaluri, Sita Jayalakshmi

AU - Shah, Harshuti

AU - Udani, Vrajesh

AU - Costello, Daniel

AU - Aguglia, Umberto

AU - Bartocci, Arnaldo

AU - Benna, Paolo

AU - Ferlazzo, Edoardo

AU - Laino, Daniela

AU - Spalice, Alberto

AU - Zanchi, Clara

AU - Ali, Amza

AU - Lim, Kheng Seang

AU - Ramirez, Alfredo

AU - Anderson, Neil

AU - Barber, Alan

AU - Cariga, Pietro

AU - Cleland, James

AU - Child, Nicholas

AU - Davis, Suzanne

AU - Dayal, Viswas

AU - Dickson, Cameron

AU - Doran, John

AU - Duncan, Roderick

AU - Giri, Pratima

AU - Herd, Michael

AU - Hutchinson, David

AU - Jones, Bethany

AU - Kao, Justin

AU - Kilfoyle, Dean

AU - Mottershead, John

AU - Muir, Colette

AU - Nolan, Melinda

AU - Pereira, Jennifer

AU - Ranta, Anna

AU - Sadani, Sneha

AU - Simpson, Mark

AU - Spooner, Claire

AU - Timmings, Paul

AU - Walker, Elizabeth

AU - Wei, Diana

AU - Willoughby, Ernest

AU - Wong, Edward

AU - Wu, Teddy

AU - Olusola, Talabi

AU - Mahmud, Hiba

AU - Mogul, Zarine

AU - Espinoza, Julio

AU - Vizarreta, Jose Hernandez

AU - Baeta, Elia Maria

AU - Teotónio, Rute

AU - Jocic-Jakubi, Bosanka

AU - Lukic, Stevo

AU - Korošec, Marko

AU - Zgur, Tomaz

AU - Eguílaz, María Gómez

AU - Asztely, Fredrik

AU - Sithinamsuwan, Pasiri

AU - Anderson, Joseph

AU - Auce, Pauls

AU - Desurkar, Archana

AU - Hamandi, Khalid

AU - Kelso, Andrew

AU - Sanchez, Violeta

AU - Sidra, Aurangzeb

AU - Smith, Phil

AU - Wehner, Tim

AU - Winston, Gavin

AU - Andrade, Edgard

AU - Bensalem-Owen, Meriem

AU - Boudreau, Michelle

AU - Caller, Tracie

AU - Chapman, Kevin

AU - Chari, Geetha

AU - Davis, Kathryn

AU - Droker, Brian

AU - El-Hagrassy, Mirret

AU - Eliashiv, Dawn

AU - Eze, Chigolum

AU - Heck, Christi

AU - Kabir, Arif

AU - Kolesnik, Dmitriy

AU - Lam, Alice

AU - Lopez, Jonathan

AU - Maamoon, Tammaa

AU - Cohen, Jennifer Madan

AU - Maganti, Rama

AU - Nwankwo, Chinasa

AU - Park, Kristen

AU - Proteasa, Simona

AU - Sandok, Evan

AU - Seinfield, Syndi

AU - Toub, Julia

AU - Wirrell, Elaine

AU - Arbildi, Marcela

AU - Thien, Truong Tran

PY - 2017/3

Y1 - 2017/3

N2 - Objective: EpiNet was established to encourage epilepsy research. EpiNet is used for multicenter cohort studies and investigator-led trials. Physicians must be accredited to recruit patients into trials. Here, we describe the accreditation process for the EpiNet-First trials. Methods: Physicians with an interest in epilepsy were invited to assess 30 case scenarios to determine the following: whether patients have epilepsy; the nature of the seizures (generalized, focal); and the etiology. Information was presented in two steps for 23 cases. The EpiNet steering committee determined that 21 cases had epilepsy. The steering committee determined by consensus which responses were acceptable for each case. We chose a subset of 18 cases to accredit investigators for the EpiNet-First trials. We initially focused on 12 cases; to be accredited, investigators could not diagnose epilepsy in any case that the steering committee determined did not have epilepsy. If investigators were not accredited after assessing 12 cases, 6 further cases were considered. When assessing the 18 cases, investigators could be accredited if they diagnosed one of six nonepilepsy patients as having possible epilepsy but could make no other false-positive errors and could make only one error regarding seizure classification. Results: Between December 2013 and December 2014, 189 physicians assessed the 30 cases. Agreement with the steering committee regarding the diagnosis at step 1 ranged from 47% to 100%, and improved when information regarding tests was provided at step 2. One hundred five of the 189 physicians (55%) were accredited for the EpiNet-First trials. The kappa value for diagnosis of epilepsy across all 30 cases for accredited physicians was 0.70. Significance: We have established criteria for accrediting physicians using EpiNet. New investigators can be accredited by assessing 18 case scenarios. We encourage physicians with an interest in epilepsy to become EpiNet-accredited and to participate in these investigator-led clinical trials.

AB - Objective: EpiNet was established to encourage epilepsy research. EpiNet is used for multicenter cohort studies and investigator-led trials. Physicians must be accredited to recruit patients into trials. Here, we describe the accreditation process for the EpiNet-First trials. Methods: Physicians with an interest in epilepsy were invited to assess 30 case scenarios to determine the following: whether patients have epilepsy; the nature of the seizures (generalized, focal); and the etiology. Information was presented in two steps for 23 cases. The EpiNet steering committee determined that 21 cases had epilepsy. The steering committee determined by consensus which responses were acceptable for each case. We chose a subset of 18 cases to accredit investigators for the EpiNet-First trials. We initially focused on 12 cases; to be accredited, investigators could not diagnose epilepsy in any case that the steering committee determined did not have epilepsy. If investigators were not accredited after assessing 12 cases, 6 further cases were considered. When assessing the 18 cases, investigators could be accredited if they diagnosed one of six nonepilepsy patients as having possible epilepsy but could make no other false-positive errors and could make only one error regarding seizure classification. Results: Between December 2013 and December 2014, 189 physicians assessed the 30 cases. Agreement with the steering committee regarding the diagnosis at step 1 ranged from 47% to 100%, and improved when information regarding tests was provided at step 2. One hundred five of the 189 physicians (55%) were accredited for the EpiNet-First trials. The kappa value for diagnosis of epilepsy across all 30 cases for accredited physicians was 0.70. Significance: We have established criteria for accrediting physicians using EpiNet. New investigators can be accredited by assessing 18 case scenarios. We encourage physicians with an interest in epilepsy to become EpiNet-accredited and to participate in these investigator-led clinical trials.

KW - Accreditation

KW - Clinical trials

KW - Diagnostic accuracy

KW - Multicenter collaboration

UR - http://www.scopus.com/inward/record.url?scp=85025158355&partnerID=8YFLogxK

U2 - 10.1002/epi4.12033

DO - 10.1002/epi4.12033

M3 - Article

AN - SCOPUS:85025158355

VL - 2

SP - 20

EP - 31

JO - Epilepsia Open

JF - Epilepsia Open

SN - 2470-9239

IS - 1

ER -

EpiNet as a way of involving more physicians and patients in epilepsy research: Validation study and accreditation process

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