Abstract
Infectious microorganisms have evolved molecules which mimic the host in order to aid in their undetected propagation. In response, mammalian hosts have evolved a highly diverse immune repertoire designed to eradicate rapidly changing pathogens. The generation of diversity in the immune repertoire results in potentially damaging self cross-reactivities which require multiple regulatory controls to keep autoreactive lymphocytes in check. Here, we review how molecular mimicry at the T cell level might be important in the development of systemic autoimmunity.
Original language | English |
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Pages (from-to) | 569-578 |
Number of pages | 10 |
Journal | Cellular and Molecular Life Sciences |
Volume | 57 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Jan 2000 |
Externally published | Yes |
Keywords
- Autoimmunity
- Determinant spreading
- Mimicry
- T cell
- Tolerance