Epitope mimics and determinant spreading: Pathways to autoimmunity

A. D. Farris, C. L. Keech, T. P. Gordon, J. McCluskey

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Infectious microorganisms have evolved molecules which mimic the host in order to aid in their undetected propagation. In response, mammalian hosts have evolved a highly diverse immune repertoire designed to eradicate rapidly changing pathogens. The generation of diversity in the immune repertoire results in potentially damaging self cross-reactivities which require multiple regulatory controls to keep autoreactive lymphocytes in check. Here, we review how molecular mimicry at the T cell level might be important in the development of systemic autoimmunity.

Original languageEnglish
Pages (from-to)569-578
Number of pages10
JournalCellular and Molecular Life Sciences
Volume57
Issue number4
DOIs
Publication statusPublished - 1 Jan 2000
Externally publishedYes

Keywords

  • Autoimmunity
  • Determinant spreading
  • Mimicry
  • T cell
  • Tolerance

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