TY - JOUR
T1 - Erectile dysfunction and later cardiovascular disease in men with type 2 diabetes
T2 - Prospective cohort study based on the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation) trial
AU - Batty, George
AU - Li, Qiang
AU - Czernichow, Sebastien
AU - Neal, Bruce
AU - Zoungas, Sophia
AU - Huxley, Rachel
AU - Patel, Anushka
AU - De Galan, Bastiaan
AU - Woodward, Mark
AU - Hamet, Pavel
AU - Harrap, Stephen
AU - Poulter, Neil
AU - Chalmers, John
PY - 2010/11/30
Y1 - 2010/11/30
N2 - Objectives The aim of this study was to examine the relationship between erectile problems in men and cardiovascular disease (CVD) mortality. Background Although there are plausible mechanisms linking erectile dysfunction (ED) with coronary heart disease (CHD) and stroke, studies are scarce. Methods In a cohort analysis of the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation) trial population, 6,304 men age 55 to 88 years with type 2 diabetes participated in a baseline medical examination when inquiries were made about ED. Over 5 years of follow-up, during which study members attended repeat clinical examinations, the presence of fatal and nonfatal CVD outcomes, cognitive decline, and dementia was ascertained. Results After adjusting for a range of covariates, including existing illness, psychological health, and classic CVD risk factors, relative to those who were free of the condition, baseline ED was associated with an elevated risk of all CVD events (hazard ratio: 1.19; 95% confidence interval: 1.08 to 1.32), CHD (hazard ratio: 1.35; 95% confidence interval: 1.16 to 1.56), and cerebrovascular disease (hazard ratio: 1.36; 95% confidence interval: 1.11 to 1.67). Men who experienced ED at baseline and at 2-year follow-up had the highest risk for these outcomes. Conclusions In this cohort of men with type 2 diabetes, ED was associated with a range of CVD events.
AB - Objectives The aim of this study was to examine the relationship between erectile problems in men and cardiovascular disease (CVD) mortality. Background Although there are plausible mechanisms linking erectile dysfunction (ED) with coronary heart disease (CHD) and stroke, studies are scarce. Methods In a cohort analysis of the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation) trial population, 6,304 men age 55 to 88 years with type 2 diabetes participated in a baseline medical examination when inquiries were made about ED. Over 5 years of follow-up, during which study members attended repeat clinical examinations, the presence of fatal and nonfatal CVD outcomes, cognitive decline, and dementia was ascertained. Results After adjusting for a range of covariates, including existing illness, psychological health, and classic CVD risk factors, relative to those who were free of the condition, baseline ED was associated with an elevated risk of all CVD events (hazard ratio: 1.19; 95% confidence interval: 1.08 to 1.32), CHD (hazard ratio: 1.35; 95% confidence interval: 1.16 to 1.56), and cerebrovascular disease (hazard ratio: 1.36; 95% confidence interval: 1.11 to 1.67). Men who experienced ED at baseline and at 2-year follow-up had the highest risk for these outcomes. Conclusions In this cohort of men with type 2 diabetes, ED was associated with a range of CVD events.
KW - Coronary heart disease
KW - Epidemiology
KW - Erectile dysfunction
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=78649376561&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2010.04.067
DO - 10.1016/j.jacc.2010.04.067
M3 - Article
SN - 0735-1097
VL - 56
SP - 1908
EP - 1913
JO - Journal of The American College of Cardiology
JF - Journal of The American College of Cardiology
IS - 23
ER -
