Estimating inspiratory neural drive and the wakefulness drive to breathe

Research output: Contribution to journalLetterpeer-review


Comment on: Compensatory responses to increased mechanical abnormalities in COPD during sleep Eur J Appl Physiol (2022) 122:663–676.

The neural control of breathing is complex with multiple descending and reflex inputs to many pools of respiratory motoneurones. This complex system provides redundancy to help maintain ventilation in the face of homeostatic challenges. In chronic obstructive pulmonary disease (COPD), diaphragm electromyographic activity (diaEMG) is increased during wakefulness, due to compromised respiratory mechanics and gas exchange. This compensatory increase during resting breathing has been documented for both the crural and costal diaphragm, and the obligatory, ‘extra-diaphragmatic’ inspiratory muscles...
Original languageEnglish
Pages (from-to)2145-2146
Number of pages2
JournalEuropean Journal of Applied Physiology
Issue number9
Early online date23 Jun 2022
Publication statusPublished - Sept 2022


  • COPD
  • Sleep
  • Breathing mechanics
  • Inspiratory neural drive
  • Airway resistance


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