Estimating renal function in morbidly obese patients

Alex Lovell, Philip Game, Gary Wittert, Campbell Thompson

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    Background: This paper aims to evaluate, in a clinical context, current creatinine-based formulas commonly used to calculate renal function in morbidly obese patients. Methods: A retrospective analysis was performed of the estimates of renal function of 63 obese or morbidly obese patients undergoing gastric bypass surgery. Each patient's glomerular filtration rate (GFR) was calculated using five methods, both before and after surgery, and these approximations were then compared. Results: Prior to surgery, the values offered by the five formulas for the renal function of this population ranged widely, by over a factor of 2. After surgery, the three weight-based GFR estimation methods indicated that a significant change in GFR had occurred, but the two non-weight-based formulas showed no significant change in estimated GFR. Conclusions: At baseline and after significant weight loss, creatinine-based formulas differ twofold in their estimates of renal function of the morbidly obese. An accurate method for calculating these patients' renal function is required to improve patient safety with drug dosing as well as to ensure early detection of renal failure.

    Original languageEnglish
    Pages (from-to)1427-1430
    Number of pages4
    JournalObesity Surgery
    Volume23
    Issue number9
    DOIs
    Publication statusPublished - Sep 2013

    Keywords

    • GFR
    • MDRD
    • Surgery
    • Weight loss

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