Ethical issues in the conduct of clinical trials in obstructive sleep apnea

Devin Brown; Craig Anderson; Ronald Chervin; Clete Kushida; Daniel Lewin; Beth Malow; Susan Redline; Edward Goldman

doi:10.5664/jcsm.28049

Ethical issues in the conduct of clinical trials in obstructive sleep apnea

Devin Brown, Craig Anderson, Ronald Chervin, Clete Kushida, Daniel Lewin, Beth Malow, Susan Redline, Edward Goldman

Research output: Contribution to journal › Article

19 Citations (Scopus)

Abstract

Scientifically rigorous clinical trials are needed to test continuous positive airway pressure's (CPAP) effect on important clinical endpoints known to be associated with obstructive sleep apnea, such as myocardial infarction, cardiac arrhythmias, stroke, mortality, seizures, and cognitive function. In this "Special Article," we review the regulatory and ethical issues that surround the design and conduct of CPAP trials, including selection of the appropriate control condition, exclusion criteria, and follow-up duration.

Original language	English
Pages (from-to)	103-108
Number of pages	6
Journal	Journal of Clinical Sleep Medicine
Volume	7
Issue number	1
DOIs	https://doi.org/10.5664/jcsm.28049
Publication status	Published - 2011

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Brown, D., Anderson, C., Chervin, R., Kushida, C., Lewin, D., Malow, B., Redline, S., & Goldman, E. (2011). Ethical issues in the conduct of clinical trials in obstructive sleep apnea. Journal of Clinical Sleep Medicine, 7(1), 103-108. https://doi.org/10.5664/jcsm.28049

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