Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience

Jerome Mertens, Maria Marchetto, Cedric Bardy, Fred Gage

    Research output: Contribution to journalArticle

    118 Citations (Scopus)

    Abstract

    The scarcity of live human brain cells for experimental access has for a long time limited our ability to study complex human neurological disorders and elucidate basic neuroscientific mechanisms. A decade ago, the development of methods to reprogramme somatic human cells into induced pluripotent stem cells enabled the in vitro generation of a wide range of neural cells from virtually any human individual. The growth of methods to generate more robust and defined neural cell types through reprogramming and direct conversion into induced neurons has led to the establishment of various human reprogramming-based neural disease models.

    Original languageEnglish
    Pages (from-to)424-437
    Number of pages14
    JournalNature Reviews Neuroscience
    Volume17
    Issue number7
    DOIs
    Publication statusPublished - 2016

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