Evaluating New Non-invasive Screening Tests for Colorectal Cancer: An In-Depth International Perspective—Introduction to a Special Issue of Digestive Diseases and Sciences

Colorectal cancer (CRC) is a global disease accounting for nearly one in 10 cancer cases and deaths which can be reduced through CRC screening. In 2023 the World Endoscopy Organization (WEO) set forth twelve newly stated principles whereby new non-invasive CRC screening tests could be efficiently evaluated by a rigorous phased comparative approach. The complexities of evaluating new and evolving CRC screening tests and the necessity for a "one size does not fit all" approach was stressed. This special issue of Digestive Diseases and Sciences expands on this document and provides in-depth discussions of several of the issues raised during its development from a global perspective.