Evaluation of a Clinic-based Exercise Program in Patients with Pancreatic Cancer Undergoing Non-Surgical Treatment

Hao Luo, Daniel A. Galvão, Robert U. Newton, Colin I. Tang, Nicolas H. Hart, Favil Singh, Andrew Dean, Kevin Jasas, Mikael Johansson, Ian Yusoff, Nigel Spry, Dennis R. Taaffe

Research output: Contribution to journalArticlepeer-review

Abstract


Introduction
Evidence regarding the role of exercise in pancreatic cancer (PanCa) is limited and is derived exclusively under tightly controlled research conditions. This study aimed to quantify adherence, adverse events, and changes in physical and psychological outcomes in any patients with PanCa referred to undertake exercise during non-surgical treatment.

Methods
The study involved 22 patients with localised or metastatic PanCa undertaking a clinic-based exercise program during chemotherapy or chemoradiotherapy. The program included supervised aerobic and resistance exercise undertaken twice weekly for 12 weeks and a 12-week follow-up with supervised exercise optional dependent on patient preference and condition. Patients were monitored for adherence and adverse events. Objective and patient-reported outcomes were assessed at baseline, 12 and 24 weeks.

Results
A total of 251 sessions were attended by 19 patients over the first 12 weeks (attendance rate: 55%). Complete case analyses indicated significant (P < .05) improvements in functional ability (5.2%-17.2%), muscle strength (16.9%-25.1%), and static balance (6.8%). There were no significant changes in body composition or patient-reported outcomes except for sleep quality which deteriorated, however, at an individual level several patients had clinically relevant improvements in cancer-related fatigue and quality of life. Patients who continued with supervised exercise to week 24 largely preserved improvements in functional ability, muscle strength, and static balance. No serious adverse events resulted from the exercise program.

Conclusions
Individualised, supervised aerobic and resistance exercise in a clinic-based setting appears to be safe, and may improve or maintain physical and psychological health in patients with PanCa undergoing non-surgical treatment.
Original languageEnglish
Number of pages35
JournalMedicine and Science in Sports and Exercise
DOIs
Publication statusAccepted/In press - 12 Jul 2022

Keywords

  • Body composition
  • Exercise
  • Pancreatic cancer
  • Physical function
  • Quality of life

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