TY - JOUR
T1 - Evaluation of an enzymatic method for determining creatinine in plasma
AU - Crocker, H.
AU - Shephard, M. D.S.
AU - White, G. H.
PY - 1988/1/1
Y1 - 1988/1/1
N2 - An enzymatic kit method for the determination of plasma creatinine was optimised for use with a centrifugal analyser and its performance characteristics and practicability compared with an end point and a kinetic Jaffe-based method. The enzymatic method exhibited several advantages over Jaffe-based methods - namely, smaller sample size, rapid sample throughput (200 per hour), and improved specificity. Glucose, acetoacetate, and cefoxitin did not interfere with the enzymatic method, although bilirubin did cause a negative interference which depended on both creatinine and bilirubin concentrations. The enzymatic method has particular clinical application in neonates, diabetic ketotic patients, and those receiving cephalosporins.
AB - An enzymatic kit method for the determination of plasma creatinine was optimised for use with a centrifugal analyser and its performance characteristics and practicability compared with an end point and a kinetic Jaffe-based method. The enzymatic method exhibited several advantages over Jaffe-based methods - namely, smaller sample size, rapid sample throughput (200 per hour), and improved specificity. Glucose, acetoacetate, and cefoxitin did not interfere with the enzymatic method, although bilirubin did cause a negative interference which depended on both creatinine and bilirubin concentrations. The enzymatic method has particular clinical application in neonates, diabetic ketotic patients, and those receiving cephalosporins.
UR - http://www.scopus.com/inward/record.url?scp=0023935008&partnerID=8YFLogxK
U2 - 10.1136/jcp.41.5.576
DO - 10.1136/jcp.41.5.576
M3 - Article
C2 - 3384988
AN - SCOPUS:0023935008
VL - 41
SP - 576
EP - 581
JO - Journal of Clinical Pathology
JF - Journal of Clinical Pathology
SN - 0021-9746
IS - 5
ER -