Evaluation of an enzymatic method for determining creatinine in plasma

H. Crocker, M. D.S. Shephard, G. H. White

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


An enzymatic kit method for the determination of plasma creatinine was optimised for use with a centrifugal analyser and its performance characteristics and practicability compared with an end point and a kinetic Jaffe-based method. The enzymatic method exhibited several advantages over Jaffe-based methods - namely, smaller sample size, rapid sample throughput (200 per hour), and improved specificity. Glucose, acetoacetate, and cefoxitin did not interfere with the enzymatic method, although bilirubin did cause a negative interference which depended on both creatinine and bilirubin concentrations. The enzymatic method has particular clinical application in neonates, diabetic ketotic patients, and those receiving cephalosporins.

Original languageEnglish
Pages (from-to)576-581
Number of pages6
JournalJournal of Clinical Pathology
Issue number5
Publication statusPublished - 1 Jan 1988
Externally publishedYes


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