Evaluation of Vitek2 and Etest for Streptococcus pneumoniae susceptibility to penicillin and ceftriaxone

Caitlyn Sun; Dabah Moukachar; Xiao Chen; Kelly Papanaoum; David L. Gordon

doi:10.1016/j.jinf.2025.106480

Evaluation of Vitek2 and Etest for Streptococcus pneumoniae susceptibility to penicillin and ceftriaxone

Caitlyn Sun, Dabah Moukachar, Xiao Chen, Kelly Papanaoum, David L. Gordon

College of Medicine and Public Health

Research output: Contribution to journal › Letter › peer-review

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Abstract

To the Editor,
Accurate Minimum Inhibitory Concentration (MIC) determination for β-lactam antibiotics is essential for the management of invasive Streptococcus pneumoniae infections. Unlike many organisms where a single breakpoint is adequate to determine susceptibility, S. pneumoniae has differing breakpoints for meningitis and non-meningitis syndromes. As such, inaccurate MIC determination can drastically alter the likelihood of therapeutic success...

Original language	English
Article number	106480
Number of pages	3
Journal	Journal of Infection
Volume	90
Issue number	4
DOIs	https://doi.org/10.1016/j.jinf.2025.106480
Publication status	Published - Apr 2025

Keywords

Streptococcus pneumoniae
management

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jinf.2025.106480Licence: CC BY-NC-ND

Final published versionFinal published version, 589 KBLicence: CC BY-NC-ND

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title = "Evaluation of Vitek2 and Etest for Streptococcus pneumoniae susceptibility to penicillin and ceftriaxone",

abstract = "To the Editor,Accurate Minimum Inhibitory Concentration (MIC) determination for β-lactam antibiotics is essential for the management of invasive Streptococcus pneumoniae infections. Unlike many organisms where a single breakpoint is adequate to determine susceptibility, S. pneumoniae has differing breakpoints for meningitis and non-meningitis syndromes. As such, inaccurate MIC determination can drastically alter the likelihood of therapeutic success...",

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AU - Sun, Caitlyn

AU - Moukachar, Dabah

AU - Chen, Xiao

AU - Papanaoum, Kelly

AU - Gordon, David L.

PY - 2025/4

Y1 - 2025/4

N2 - To the Editor,Accurate Minimum Inhibitory Concentration (MIC) determination for β-lactam antibiotics is essential for the management of invasive Streptococcus pneumoniae infections. Unlike many organisms where a single breakpoint is adequate to determine susceptibility, S. pneumoniae has differing breakpoints for meningitis and non-meningitis syndromes. As such, inaccurate MIC determination can drastically alter the likelihood of therapeutic success...

AB - To the Editor,Accurate Minimum Inhibitory Concentration (MIC) determination for β-lactam antibiotics is essential for the management of invasive Streptococcus pneumoniae infections. Unlike many organisms where a single breakpoint is adequate to determine susceptibility, S. pneumoniae has differing breakpoints for meningitis and non-meningitis syndromes. As such, inaccurate MIC determination can drastically alter the likelihood of therapeutic success...

KW - Streptococcus pneumoniae

KW - management

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U2 - 10.1016/j.jinf.2025.106480

DO - 10.1016/j.jinf.2025.106480

M3 - Letter

AN - SCOPUS:105001236481

SN - 0163-4453

VL - 90

JO - Journal of Infection

JF - Journal of Infection

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ER -

Evaluation of Vitek2 and Etest for Streptococcus pneumoniae susceptibility to penicillin and ceftriaxone

Abstract

Keywords

UN SDGs

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