TY - JOUR
T1 - Evidence for a dual action of sulphinpyrazone on drug metabolism in man
T2 - theophylline‐sulphinpyrazone interaction.
AU - Birkett, DJ
AU - Miners, JO
AU - Attwood, J.
PY - 1983/5
Y1 - 1983/5
N2 - The effects of sulphinpyrazone administration on the metabolic and renal clearances of theophylline in man were investigated. Sulphinpyrazone increased total plasma theophylline clearance by 22%. This was the sum of increases in metabolic clearances by 3‐ demethylation (32%), 1‐demethylation (30%) and 8‐oxidation (22%) and of a decrease in renal clearance (27%). It is proposed that sulphinpyrazone has differential effects on at least two forms of cytochrome P‐450 inhibiting one enzyme or group of enzymes which metabolises tolbutamide, phenytoin and S(‐)warfarin and inducing a form (or forms) which metabolises theophylline, antipyrine and R(+)warfarin. 1983 The British Pharmacological Society
AB - The effects of sulphinpyrazone administration on the metabolic and renal clearances of theophylline in man were investigated. Sulphinpyrazone increased total plasma theophylline clearance by 22%. This was the sum of increases in metabolic clearances by 3‐ demethylation (32%), 1‐demethylation (30%) and 8‐oxidation (22%) and of a decrease in renal clearance (27%). It is proposed that sulphinpyrazone has differential effects on at least two forms of cytochrome P‐450 inhibiting one enzyme or group of enzymes which metabolises tolbutamide, phenytoin and S(‐)warfarin and inducing a form (or forms) which metabolises theophylline, antipyrine and R(+)warfarin. 1983 The British Pharmacological Society
UR - http://www.scopus.com/inward/record.url?scp=0020598545&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2125.1983.tb02093.x
DO - 10.1111/j.1365-2125.1983.tb02093.x
M3 - Article
C2 - 6860533
AN - SCOPUS:0020598545
SN - 0306-5251
VL - 15
SP - 567
EP - 569
JO - British Journal of Clinical Pharmacology
JF - British Journal of Clinical Pharmacology
IS - 5
ER -