Evidence for a dual action of sulphinpyrazone on drug metabolism in man: theophylline‐sulphinpyrazone interaction.

DJ Birkett, JO Miners, J. Attwood

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)

    Abstract

    The effects of sulphinpyrazone administration on the metabolic and renal clearances of theophylline in man were investigated. Sulphinpyrazone increased total plasma theophylline clearance by 22%. This was the sum of increases in metabolic clearances by 3‐ demethylation (32%), 1‐demethylation (30%) and 8‐oxidation (22%) and of a decrease in renal clearance (27%). It is proposed that sulphinpyrazone has differential effects on at least two forms of cytochrome P‐450 inhibiting one enzyme or group of enzymes which metabolises tolbutamide, phenytoin and S(‐)warfarin and inducing a form (or forms) which metabolises theophylline, antipyrine and R(+)warfarin. 1983 The British Pharmacological Society

    Original languageEnglish
    Pages (from-to)567-569
    Number of pages3
    JournalBritish Journal of Clinical Pharmacology
    Volume15
    Issue number5
    DOIs
    Publication statusPublished - May 1983

    Fingerprint Dive into the research topics of 'Evidence for a dual action of sulphinpyrazone on drug metabolism in man: theophylline‐sulphinpyrazone interaction.'. Together they form a unique fingerprint.

    Cite this