Evidence for a dual action of sulphinpyrazone on drug metabolism in man: theophylline‐sulphinpyrazone interaction.

DJ Birkett, JO Miners, J. Attwood

    Research output: Contribution to journalArticle

    26 Citations (Scopus)

    Abstract

    The effects of sulphinpyrazone administration on the metabolic and renal clearances of theophylline in man were investigated. Sulphinpyrazone increased total plasma theophylline clearance by 22%. This was the sum of increases in metabolic clearances by 3‐ demethylation (32%), 1‐demethylation (30%) and 8‐oxidation (22%) and of a decrease in renal clearance (27%). It is proposed that sulphinpyrazone has differential effects on at least two forms of cytochrome P‐450 inhibiting one enzyme or group of enzymes which metabolises tolbutamide, phenytoin and S(‐)warfarin and inducing a form (or forms) which metabolises theophylline, antipyrine and R(+)warfarin. 1983 The British Pharmacological Society

    Original languageEnglish
    Pages (from-to)567-569
    Number of pages3
    JournalBritish Journal of Clinical Pharmacology
    Volume15
    Issue number5
    DOIs
    Publication statusPublished - May 1983

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