TY - JOUR
T1 - Evidence for negative interference
T2 - Clustering of crossovers close to the am locus in Neurospora crassa among am recombinants
AU - Bowring, Frederick J.
AU - Catcheside, David E.A.
N1 - Copyright © 1999 by the Genetics Society of America
PY - 1999/7/1
Y1 - 1999/7/1
N2 - In response to a conflict between two mapping studies in the predicted orientation of the allele map with respect to the centromere, Fincham proposed that recombination events at the Neurospora am locus rarely have an associated crossover. Fincham considered that the elevated levels of crossing over between flanking markers in am recombinants resulted from negative interference, an increased probability of a nearby second event, and on this basis predicted a clustering of crossing over near am in these recombinants. In this article we reevaluate the data from three mapping studies of the am locus and report molecular evidence that shows crossovers to be clustered immediately proximal to am in am recombinants.
AB - In response to a conflict between two mapping studies in the predicted orientation of the allele map with respect to the centromere, Fincham proposed that recombination events at the Neurospora am locus rarely have an associated crossover. Fincham considered that the elevated levels of crossing over between flanking markers in am recombinants resulted from negative interference, an increased probability of a nearby second event, and on this basis predicted a clustering of crossing over near am in these recombinants. In this article we reevaluate the data from three mapping studies of the am locus and report molecular evidence that shows crossovers to be clustered immediately proximal to am in am recombinants.
UR - http://www.scopus.com/inward/record.url?scp=0032779461&partnerID=8YFLogxK
M3 - Article
C2 - 10388816
AN - SCOPUS:0032779461
SN - 0016-6731
VL - 152
SP - 965
EP - 969
JO - Genetics
JF - Genetics
IS - 3
ER -