Evidence for negative interference: Clustering of crossovers close to the am locus in Neurospora crassa among am recombinants

Frederick J. Bowring, David E.A. Catcheside

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    In response to a conflict between two mapping studies in the predicted orientation of the allele map with respect to the centromere, Fincham proposed that recombination events at the Neurospora am locus rarely have an associated crossover. Fincham considered that the elevated levels of crossing over between flanking markers in am recombinants resulted from negative interference, an increased probability of a nearby second event, and on this basis predicted a clustering of crossing over near am in these recombinants. In this article we reevaluate the data from three mapping studies of the am locus and report molecular evidence that shows crossovers to be clustered immediately proximal to am in am recombinants.

    Original languageEnglish
    Pages (from-to)965-969
    Number of pages5
    JournalGenetics
    Volume152
    Issue number3
    Publication statusPublished - 1 Jul 1999

    Bibliographical note

    Copyright © 1999 by the Genetics Society of America

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