Evidence of chromosomal damage in scleroderma

K. A. Patterson, J. G. Walker, P. J. Roberts-Thomson, C. F. Bull, M. Fenech

Research output: Contribution to journalLetterpeer-review

Abstract

Sir, 
Systemic sclerosis (scleroderma, SSc) is an uncommon heterogeneous connective tissue disease considered to have an autoimmune origin.1 Cancer occurs more commonly in scleroderma2 and we have previously documented acquired genetic damage at the glycophorin-A locus suggesting genomic instability.

Original languageEnglish
Pages (from-to)131-133
Number of pages3
JournalPathology
Volume54
Issue number1
DOIs
Publication statusPublished - Feb 2022
Externally publishedYes

Keywords

  • scleroderma
  • chromosomal damage
  • Systemic sclerosis
  • peripheral blood lymphocytes (PBL)
  • cytokinesis-block micronucleus cytome (CBMN-cyt)
  • genomic instability

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