Evidence of chromosomal damage in scleroderma

K. A. Patterson, J. G. Walker, P. J. Roberts-Thomson, C. F. Bull, M. Fenech

Research output: Contribution to journalLetterpeer-review

Abstract

Sir, 
Systemic sclerosis (scleroderma, SSc) is an uncommon heterogeneous connective tissue disease considered to have an autoimmune origin.1 Cancer occurs more commonly in scleroderma2 and we have previously documented acquired genetic damage at the glycophorin-A locus suggesting genomic instability.

Original languageEnglish
Number of pages3
JournalPathology
DOIs
Publication statusAccepted/In press - 30 Jun 2021
Externally publishedYes

Keywords

  • scleroderma
  • chromosomal damage
  • Systemic sclerosis
  • peripheral blood lymphocytes (PBL)
  • cytokinesis-block micronucleus cytome (CBMN-cyt)
  • genomic instability

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